KEGG   DRUG: SulfasalazineHelp
Entry
D00448                      Drug                                   

Name
Sulfasalazine (USP/INN);
Salazosulfapyridine (JP17);
Azulfidine (TN)
Product
  Generic
Formula
C18H14N4O5S
Exact mass
398.0685
Mol weight
398.3926
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-inflammatory
 DG01909  Antiinflammatory drug, salicylic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01909  Antiinflammatory drug, salicylic acid derivatives
Other
 DG01668  Aminosalicylic acid derivative
Transporter substrate
 DG01913  BCRP substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antirheumatic, Anti-inflammatory
Comment
Sulfonamide, Salicylic acid derivative
Metabolism
Transporter: ABCG2 [HSA:9429]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - sulfa drugs
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EC Aminosalicylic acid and similar agents
     A07EC01 Sulfasalazine
      D00448  Sulfasalazine (USP/INN)
USP drug classification [BR:br08302]
 Inflammatory Bowel Disease Agents
  Sulfonamides
   Sulfasalazine
    D00448  Sulfasalazine (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   621  Sulfonamides
    6219  Others
     D00448  Sulfasalazine (USP/INN); Salazosulfapyridine (JP17)
Cytochrome P450 interactions [BR:br08309]
 Transporter inhibitors
  ABCG2
   Sulfasalazine
    D00448  Sulfasalazine (USP/INN)
 Transporter substrates
  ABCG2
   Sulfasalazine
    D00448  Sulfasalazine (USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00448  Salazosulfapyridine
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D00448
BRITE hierarchy
Other DBs
CAS: 
599-79-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    28.3837  -14.8490
            2   S4a S    29.5179  -14.1825
            3   C8x C    28.3837  -16.1643
            4   C8x C    27.2437  -14.1825
            5   N1b N    30.6638  -14.8490
            6   O3c O    28.3779  -13.2470
            7   O3c O    30.6989  -13.2470
            8   C8x C    27.2437  -16.8190
            9   C8x C    26.1096  -14.8490
            10  C8y C    31.8038  -14.1825
            11  C8y C    26.1096  -16.1643
            12  C8x C    31.7921  -12.8670
            13  N5x N    32.9438  -14.8373
            14  N2b N    24.9637  -16.8190
            15  C8x C    32.9321  -12.2063
            16  C8x C    34.0838  -14.1766
            17  N2b N    23.6424  -16.1234
            18  C8x C    34.0780  -12.8613
            19  C8y C    22.3504  -16.8718
            20  C8x C    22.3504  -18.3683
            21  C8x C    21.0585  -16.1234
            22  C8y C    21.0585  -19.1166
            23  C8x C    19.7604  -16.8718
            24  C8y C    19.7664  -18.3683
            25  C6a C    21.0585  -20.6134
            26  O1a O    18.4685  -19.1226
            27  O6a O    22.3563  -21.3615
            28  O6a O    19.7664  -21.3615
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     2   7 2
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    8  11 1
            11   10  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 2
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   17  19 1
            19   19  20 1
            20   19  21 2
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24   22  25 1
            25   24  26 1
            26   25  27 1
            27   25  28 2
            28    9  11 2
            29   16  18 2
            30   23  24 2

» Japanese version   » Back

DBGET integrated database retrieval system