KEGG   DRUG: D00454Help
Entry
D00454                      Drug                                   

Name
Olanzapine (JAN/USAN/INN);
Zyprexa (TN)
Product
  Generic
OLANZAPINE (American Health Packaging), OLANZAPINE (American Health Packaging), OLANZAPINE (American Regent), OLANZAPINE (Apotex Corp.), OLANZAPINE (Apotex Corp.), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (AvPAK), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Cardinal Health), OLANZAPINE (Cardinal Health), OLANZAPINE (Cardinal Health), OLANZAPINE (Citron Pharma LLC), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Dispensing Solutions), OLANZAPINE (Dispensing Solutions), OLANZAPINE (Dr. Reddy's Laboratories Limited), OLANZAPINE (Dr.Reddy's Laboratories), OLANZAPINE (Dr.Reddy's Laboratories Limited), OLANZAPINE (Dr.Reddy's laboratories), OLANZAPINE (Dr.Reddy's laboratories), OLANZAPINE (Gen-Source Rx), OLANZAPINE (Golden State Medical Supply), OLANZAPINE (Jubilant Cadista Pharmaceuticals), OLANZAPINE (Lake Erie Medical DBA Quality Care Products LLC), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Mylan Institutional), OLANZAPINE (Mylan Pharmaceuticals), OLANZAPINE (Mylan Pharmaceuticals), OLANZAPINE (Par Pharmaceutical), OLANZAPINE (Physicians Total Care), OLANZAPINE (Prasco Laboratories), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Sandoz), OLANZAPINE (Sun Pharmaceutical Industries Limited), OLANZAPINE (Sun Pharmaceutical Industries Limited), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Torrent Pharmaceuticals Limited)
Formula
C17H20N4S
Exact mass
312.1409
Mol weight
312.4325
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT2C-receptor antagonist [HSA:3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
dopamine D3-receptor antagonist [HSA:1814] [KO:K04146];
dopamine D4-receptor antagonist [HSA:1815] [KO:K04147]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Benzodiazepine family
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH03 Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00454  Olanzapine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
   Dopamine
    dopamine D2-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
    dopamine D3-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
    dopamine D4-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
   Histamine
    H1-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
   Serotonin
    5-HT2A-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
    5-HT2C-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
  CYP2D6
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
132539-06-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    18.4919  -10.5513
            2   C8y C    17.6483   -9.4316
            3   C8y C    17.9905   -8.0673
            4   N4x N    19.2617   -7.4901
            5   N5x N    19.9065  -10.5817
            6   C8y C    20.5211   -8.1208
            7   C8y C    20.8046   -9.4994
            8   S2x S    16.7987   -7.3203
            9   C8y C    15.7200   -8.2230
            10  C8x C    16.2450   -9.4575
            11  C1a C    14.3803   -7.9003
            12  N1y N    17.7660  -11.7484
            13  C8x C    22.1331   -9.9409
            14  C8x C    23.1798   -9.0111
            15  C8x C    22.8963   -7.6326
            16  C8x C    21.5678   -7.1910
            17  C1x C    16.3806  -11.7887
            18  C1x C    15.7162  -13.0210
            19  N1y N    16.4511  -14.2126
            20  C1x C    17.8365  -14.2422
            21  C1x C    18.5010  -12.9400
            22  C1a C    15.7566  -15.4262
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13    1  12 1
            14    7  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18    6  16 2
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   12  21 1
            25   19  22 1

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