KEGG   DRUG: OlanzapineHelp
Entry
D00454                      Drug                                   

Name
Olanzapine (JAN/USAN/INN);
Zyprexa (TN)
Product
  Generic
OLANZAPINE (American Health Packaging), OLANZAPINE (American Health Packaging), OLANZAPINE (American Health Packaging), OLANZAPINE (American Regent), OLANZAPINE (Aphena Pharma Solutions - Tennessee), OLANZAPINE (Apotex Corp.), OLANZAPINE (Apotex Corp.), OLANZAPINE (Ascend Laboratories), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (AvPAK), OLANZAPINE (Avera McKennan Hospital), OLANZAPINE (Avera McKennan Hospital), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Cardinal Health), OLANZAPINE (Cardinal Health), OLANZAPINE (Cardinal Health), OLANZAPINE (Cardinal Health), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Dispensing Solutions), OLANZAPINE (Dispensing Solutions), OLANZAPINE (Dr.Reddy's Laboratories), OLANZAPINE (Dr.Reddy's Laboratories Limited), OLANZAPINE (Dr.Reddy's Laboratories Limited), OLANZAPINE (Dr.Reddy's laboratories), OLANZAPINE (Golden State Medical Supply), OLANZAPINE (Jubilant Cadista Pharmaceuticals), OLANZAPINE (LUCID PHARMA LLC), OLANZAPINE (Lake Erie Medical DBA Quality Care Products LLC), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Mylan Institutional), OLANZAPINE (Mylan Pharmaceuticals), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (Par Pharmaceutical), OLANZAPINE (Physicians Total Care), OLANZAPINE (Prasco Laboratories), OLANZAPINE (Prasco Laboratories), OLANZAPINE (Prasco Laboratories), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Qilu Pharmaceutical), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Sandoz), OLANZAPINE (Sandoz), OLANZAPINE (Sun Pharmaceutical Industries Limited), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Torrent Pharmaceuticals Limited)
Formula
C17H20N4S
Exact mass
312.1409
Mol weight
312.4325
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
  DG01475  Dopamine D3-receptor antagonist
  DG01476  Dopamine D4-receptor antagonist
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antipsychotic
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
5-HT2A-receptor [HSA:3356] [KO:K04157];
5-HT2C-receptor [HSA:3358] [KO:K04157];
H1-receptor [HSA:3269] [KO:K04149];
alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135];
dopamine D2-receptor [HSA:1813] [KO:K04145];
dopamine D3-receptor [HSA:1814] [KO:K04146];
dopamine D4-receptor [HSA:1815] [KO:K04147]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Gap junction
Salivary secretion
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Benzodiazepine family
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH03 Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00454  Olanzapine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
   Dopamine
    dopamine D2-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
    dopamine D3-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
    dopamine D4-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
   Histamine
    H1-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
   Serotonin
    5-HT2A-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
    5-HT2C-receptor
     Olanzapine
      D00454  Olanzapine (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
  CYP2D6
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
Psychiatric agents [br08363.html]
 Antipsychotics
  D00454
BRITE hierarchy
Other DBs
CAS: 
132539-06-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    18.4919  -10.5513
            2   C8y C    17.6483   -9.4316
            3   C8y C    17.9905   -8.0673
            4   N4x N    19.2617   -7.4901
            5   N5x N    19.9065  -10.5817
            6   C8y C    20.5211   -8.1208
            7   C8y C    20.8046   -9.4994
            8   S2x S    16.7987   -7.3203
            9   C8y C    15.7200   -8.2230
            10  C8x C    16.2450   -9.4575
            11  C1a C    14.3803   -7.9003
            12  N1y N    17.7660  -11.7484
            13  C8x C    22.1331   -9.9409
            14  C8x C    23.1798   -9.0111
            15  C8x C    22.8963   -7.6326
            16  C8x C    21.5678   -7.1910
            17  C1x C    16.3806  -11.7887
            18  C1x C    15.7162  -13.0210
            19  N1y N    16.4511  -14.2126
            20  C1x C    17.8365  -14.2422
            21  C1x C    18.5010  -12.9400
            22  C1a C    15.7566  -15.4262
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13    1  12 1
            14    7  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18    6  16 2
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   12  21 1
            25   19  22 1

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