KEGG   DRUG: D00455Help
Entry
D00455                      Drug                                   

Name
Omeprazole (JP16/USP/INN);
Prilosec (TN)
Product
  Generic
OMEPRAZOLE (Actavis Pharma), OMEPRAZOLE (Aidarex Pharmaceuticals LLC), OMEPRAZOLE (Aidarex Pharmaceuticals LLC), OMEPRAZOLE (Altura Pharmaceuticals), OMEPRAZOLE (American Health Packaging), OMEPRAZOLE (American Health Packaging), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Apotex Corp), OMEPRAZOLE (AvPAK), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Blenheim Pharmacal), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Cadila Healthcare Limited), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Cardinal Health), OMEPRAZOLE (Clinical Solutions Wholesale), OMEPRAZOLE (Contract Pharmacy Services-PA), OMEPRAZOLE (Dispensing Solutions), OMEPRAZOLE (Dr. Reddy's Laboratories Limited), OMEPRAZOLE (Dr. Reddy's Laboratories Limited), OMEPRAZOLE (Glenmark Generics), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (H.J. Harkins Company), OMEPRAZOLE (KAISER FOUNDATION HOSPITALS), OMEPRAZOLE (KAISER FOUNDATION HOSPITALS), OMEPRAZOLE (Kremers Urban Pharmaceuticals), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Lake Erie Medical DBA Quality Care Products LLC), OMEPRAZOLE (Legacy Pharmaceutical Packaging), OMEPRAZOLE (Legacy Pharmaceutical Packaging), OMEPRAZOLE (Life Line Home Care Services), OMEPRAZOLE (Major Pharmaceuticals), OMEPRAZOLE (Major Pharmaceuticals), OMEPRAZOLE (McKesson Contract Packaging), OMEPRAZOLE (McKesson Packaging Services a business unit of McKesson Corporation), OMEPRAZOLE (Medsource Pharmaceuticals), OMEPRAZOLE (Midwest Drug Distribution), OMEPRAZOLE (Mylan Institutional), OMEPRAZOLE (Mylan Pharmaceuticals), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (New Horizon Rx Group), OMEPRAZOLE (Northwind Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (Physicians Total Care), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (ReadyMeds), OMEPRAZOLE (Rebel Distributors Corp), OMEPRAZOLE (Rebel Distributors Corp), OMEPRAZOLE (Rebel Distributors Corp.), OMEPRAZOLE (RxChange), OMEPRAZOLE (STAT Rx USA LLC), OMEPRAZOLE (STAT Rx USA LLC), OMEPRAZOLE (Safecor Health), OMEPRAZOLE (Sandoz), OMEPRAZOLE (St Marys Medical Park Pharmacy), OMEPRAZOLE (State of Florida DOH Central Pharmacy), OMEPRAZOLE (State of Florida DOH Central Pharmacy), OMEPRAZOLE (TYA Pharmaceuticals), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Unit Dose Services), OMEPRAZOLE (Zydus Pharmaceuticals (USA)), OMEPRAZOLE DR (Direct Rx), OMEPRAZOLE (Northwind Pharmaceuticals)
Formula
C17H19N3O3S
Exact mass
345.1147
Mol weight
345.4161
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Depressant [gastric acid secretory] [DS:H00045]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
proton pump inhibitor
prodrug
Target
H+/K+ exchanging, alpha polypeptide inhibitor [HSA:495] [KO:K01542];
H+/K+ exchanging, beta polypeptide inhibitor [HSA:496] [KO:K01543]
  Pathway
Oxidative phosphorylation
Collecting duct acid secretion
Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP induction: CYP1A2 [HSA:1544]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antiulcer drugs
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC01 Omeprazole
      D00455  Omeprazole (JP16/USP/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Omeprazole
    D00455  Omeprazole (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00455  Omeprazole (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Omeprazol
     D00455  Omeprazole (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Omeprazole
    D00455  Omeprazole (JP16/USP/INN)
  CYP3A4
   Omeprazole
    D00455  Omeprazole (JP16/USP/INN)
 Inhbitors
  CYP2C19
   Omeprazole
    D00455  Omeprazole (JP16/USP/INN)
 Inducers
  CYP1A2
   Omeprazole
    D00455  Omeprazole (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00455  Omeprazole
  D00455  Omeprazole enteric-coated tablets
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00455
Rx-to-OTC switch list in the USA [br08315.html]
 D00455
BRITE hierarchy
Other DBs
CAS: 
73590-58-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8x C    14.6300  -20.7200
            2   C8y C    14.6300  -22.1200
            3   C8x C    15.8424  -22.8200
            4   C8y C    17.0549  -22.1200
            5   C8y C    17.0549  -20.7200
            6   C8x C    15.8424  -20.0200
            7   N5x N    18.3864  -22.5526
            8   C8y C    19.2093  -21.4200
            9   N4x N    18.3864  -20.2874
            10  S4a S    20.5800  -21.4200
            11  O2a O    13.4176  -22.8200
            12  C1a C    12.2221  -22.1296
            13  C1b C    21.2800  -22.6324
            14  O3c O    21.2800  -20.2076
            15  C8y C    22.6798  -22.6324
            16  C8y C    23.3703  -23.8280
            17  C8y C    24.7703  -23.8278
            18  C8y C    25.4701  -22.6153
            19  C8x C    24.7797  -21.4198
            20  N5x N    23.3797  -21.4199
            21  C1a C    26.8800  -22.6152
            22  O2a O    25.4610  -25.0232
            23  C1a C    26.8796  -25.0232
            24  C1a C    22.6849  -25.0152
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    2  11 1
            13   11  12 1
            14   10  13 1
            15   10  14 2
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   18  21 1
            24   17  22 1
            25   22  23 1
            26   16  24 1

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