KEGG   DRUG: D00456Help
Entry
D00456                      Drug                                   
Name
Ondansetron (JAN/USP/INN);
Zofran ODT (TN)
Product
  Generic
ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health), ONDANSETRON (Dispensing Solutions), ONDANSETRON (Dispensing Solutions), ONDANSETRON (Greenstone LLC), ONDANSETRON (HHS/Program Support Center/Supply Service Center), ONDANSETRON (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Mylan Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Physicians Total Care), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Ranbaxy Pharmaceuticals), ONDANSETRON (Rebel Distributors Corp), ONDANSETRON (Rebel Distributors Corp), ONDANSETRON (Rebel Distributors Corp), ONDANSETRON (Rebel Distributors Corp.), ONDANSETRON (Sandoz), ONDANSETRON (Stat Rx USA), ONDANSETRON (Sun Pharmaceutical Industries Limited), ONDANSETRON (Unit Dose Services)
Formula
C18H19N3O
Exact mass
293.1528
Mol weight
293.363
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anxiety agent;
Anti-emetic;
Antischizophrenic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Pathway map
Bile secretion
Structure map
Serotonin receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00456  Ondansetron (JAN/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00456  Ondansetron (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Serotonin-3 (5-HT3) Receptor Antagonist
    Ondansetron
     D00456  Ondansetron (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT3-receptor [HSA:3359 9177 170572 200909 285242] [KO:K04819]
     Ondansetron [ATC:A04AA01]
      D00456  Ondansetron (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
99614-02-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    33.5159  -17.7325
            2   C8y C    34.8490  -18.1807
            3   C8y C    33.5217  -16.3295
            4   C5x C    32.3109  -18.4368
            5   C8y C    35.6698  -17.0396
            6   C8x C    35.4254  -19.4557
            7   N4y N    34.8607  -15.9044
            8   C1x C    32.3109  -15.6367
            9   C1y C    31.0941  -17.7325
            10  O5x O    32.3166  -19.8341
            11  C8x C    37.0613  -17.1794
            12  C8x C    36.8167  -19.5896
            13  C1a C    35.2972  -14.5771
            14  C1x C    31.0941  -16.3295
            15  C1b C    29.8831  -18.4368
            16  C8x C    37.6318  -18.4544
            17  N4y N    28.6780  -17.7325
            18  C8y C    28.7203  -16.3253
            19  C8x C    27.3348  -18.1219
            20  N5x N    27.3985  -15.8508
            21  C1a C    29.8791  -15.5437
            22  C8x C    26.5473  -16.9625
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1

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