KEGG   DRUG: D00457Help
Entry
D00457                      Drug                                   

Name
Quazepam (JAN/USP/INN);
Doral (TN)
Product
Formula
C17H11ClF4N2S
Exact mass
386.0268
Mol weight
386.7943
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD10 Quazepam
      D00457  Quazepam (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00457  Quazepam (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Quazepam
      D00457  Quazepam (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Quazepam
    D00457  Quazepam (JAN/USP/INN)
  CYP3A4
   Quazepam
    D00457  Quazepam (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
36735-22-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C2y C    14.2831  -12.8278
            2   C8y C    13.4404  -11.7174
            3   C8y C    13.7759  -10.3597
            4   N1y N    15.0377   -9.7811
            5   N2x N    15.6899  -12.7830
            6   C2y C    16.2922  -10.4039
            7   C1x C    16.5789  -11.7736
            8   C8x C    12.7680   -9.3906
            9   C8x C    11.4251   -9.7789
            10  C8y C    11.0897  -11.1367
            11  C8x C    12.0975  -12.1055
            12  S0  S    17.3371   -9.4688
            13  X   Cl    9.7239  -11.5314
            14  C8y C    13.6482  -14.0784
            15  C8x C    12.2456  -14.0784
            16  C8x C    11.5451  -15.2917
            17  C8x C    12.2456  -16.5050
            18  C8x C    13.6482  -16.5050
            19  C8y C    14.3487  -15.2917
            20  X   F    15.7606  -15.2918
            21  C1b C    15.0595   -8.0553
            22  C1d C    16.2778   -7.3773
            23  X   F    17.4902   -6.6773
            24  X   F    16.9643   -8.5877
            25  X   F    15.5836   -6.1532
BOND        27
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   14  19 2
            22   19  20 1
            23    4  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1

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