KEGG   DRUG: D00459Help
Entry
D00459                      Drug                                   

Name
Quinapril hydrochloride (JP16/USP);
Accupril (TN)
Product
  Generic
QUINAPRIL (AvKARE), QUINAPRIL (AvPAK), QUINAPRIL (BluePoint Laboratories), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Camber Pharmaceuticals), QUINAPRIL (Cardinal Health), QUINAPRIL (Dr.Reddy's Laboratories Limited), QUINAPRIL (Lake Erie Medical DBA Quality Care Products LLC), QUINAPRIL (Lupin Pharmaceuticals), QUINAPRIL (Physicians Total Care), QUINAPRIL (Ranbaxy Pharmaceuticals), QUINAPRIL (Rebel Distributors Corp), QUINAPRIL (Sun Pharmaceutical Industries Limited), QUINAPRIL (Aurobindo Pharma Limited), QUINAPRIL HYDROCHLORIDE (Carilion Materials Management), QUINAPRIL HYDROCHLORIDE (Carilion Materials Management), QUINAPRIL HYDROCHLORIDE (Carilion Materials Management), QUINAPRIL HYDROCHLORIDE (Greenstone LLC), QUINAPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals)
Formula
C25H30N2O5. HCl
Exact mass
474.1922
Mol weight
474.977
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive;
Enzyme inhibitor [angiotensin-converting]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Quinaprilat [DR:D03773]
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Interaction
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA06 Quinapril
      D00459  Quinapril hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Quinapril
    D00459  Quinapril hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00459  Quinapril hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE)
    Quinapril
     D00459  Quinapril hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00459  Quinapril hydrochloride
  D00459  Quinapril hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 
82586-55-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1x C    28.2490  -19.8211
            2   C8y C    29.4582  -19.1183
            3   N1y N    27.0337  -19.1187
            4   C8y C    29.4645  -17.7270
            5   C8x C    30.6604  -19.8200
            6   C1y C    27.0378  -17.7192
            7   C1x C    28.2493  -17.0245
            8   C8x C    30.6680  -17.0343
            9   C8x C    31.8720  -19.1253
            10  C8x C    31.8732  -17.7311
            11  N1b N    23.4099  -19.8234
            12  C1c C    22.1992  -19.1275
            13  C7a C    22.1933  -17.7238
            14  C1b C    20.9826  -19.8351
            15  O7a O    23.4099  -17.0219
            16  O6a O    20.9709  -17.0277
            17  C1b C    19.7661  -19.1450
            18  C1b C    23.4040  -15.6182
            19  C8y C    18.5554  -19.8351
            20  C1a C    22.1875  -14.9223
            21  C8x C    18.5554  -21.2506
            22  C8x C    17.3506  -19.1450
            23  C8x C    17.3506  -21.9582
            24  C8x C    16.1282  -19.8351
            25  C8x C    16.1282  -21.2506
            26  C1c C    24.6167  -19.1187
            27  C5a C    25.8252  -19.8183
            28  O5a O    25.8252  -21.2177
            29  C1a C    24.6140  -17.7194
            30  C6a C    27.0266  -16.3129
            31  O6a O    28.2329  -15.6036
            32  O6a O    25.8093  -15.6229
            33  X   Cl   30.5428  -21.2516
BOND        34
            1     8  10 2
            2     6   7 1
            3     9  10 1
            4    11  12 1
            5    12  13 1 #Up
            6    12  14 1
            7    13  15 1
            8    13  16 2
            9    14  17 1
            10   15  18 1
            11   17  19 1
            12   18  20 1
            13   19  21 1
            14   19  22 2
            15   21  23 2
            16   22  24 1
            17   23  25 1
            18   24  25 2
            19    1   2 1
            20   11  26 1
            21    1   3 1
            22   26  27 1
            23   27   3 1
            24    2   4 2
            25   27  28 2
            26    2   5 1
            27   26  29 1 #Up
            28    3   6 1
            29    6  30 1 #Down
            30    4   7 1
            31   30  31 1
            32    4   8 1
            33   30  32 2
            34    5   9 2

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