KEGG   DRUG: D00463Help
Entry
D00463                      Drug                                   

Name
Oxaprozin (JP16/USAN/INN);
Daypro (TN)
Product
  Generic
Formula
C18H15NO3
Exact mass
293.1052
Mol weight
293.3166
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-inflammatory [DS:H00445 H00630]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
hsa04370  VEGF signaling pathway  
 
Interaction
Drug interaction
Structure map
1,2-Diphenyl substitution family
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE12 Oxaprozin
      D00463  Oxaprozin (JP16/USAN/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Oxaprozin
    D00463  Oxaprozin (JP16/USAN/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Oxaprozin
    D00463  Oxaprozin (JP16/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00463  Oxaprozin (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Oxaprozin
     D00463  Oxaprozin (JP16/USAN/INN)
   cyclooxygenase-2 (COX-2)
    Oxaprozin
     D00463  Oxaprozin (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00463  Oxaprozin
BRITE hierarchy
Other DBs
CAS: 
21256-18-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    25.8557  -17.0142
            2   C1b C    27.2577  -17.0142
            3   N5x N    25.0145  -15.8927
            4   C8y C    23.7060  -16.3132
            5   C8y C    23.7060  -17.7152
            6   O2x O    25.0145  -18.1358
            7   C8x C    20.0609  -14.2103
            8   C8x C    20.0609  -15.6123
            9   C8x C    21.2760  -16.3132
            10  C8y C    22.4910  -15.6123
            11  C8x C    22.4910  -14.2103
            12  C8x C    21.2760  -13.5093
            13  C8x C    20.0609  -18.4162
            14  C8x C    20.0609  -19.8181
            15  C8x C    21.2760  -20.5191
            16  C8x C    22.4910  -19.8181
            17  C8y C    22.4910  -18.4162
            18  C8x C    21.2760  -17.7152
            19  C1b C    27.9586  -15.8000
            20  C6a C    29.3606  -15.8000
            21  O6a O    30.0620  -14.5852
            22  O6a O    30.0612  -17.0135
BOND        24
            1     1   2 1
            2     1   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    7  12 1
            13   10   4 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   13  18 1
            20   17   5 1
            21    2  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 2

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