KEGG   DRUG: OxaprozinHelp
Entry
D00463                      Drug                                   

Name
Oxaprozin (JP17/USAN/INN);
Daypro (TN)
Product
  Generic
OXAPROZIN (American Health Packaging), OXAPROZIN (Amneal Pharmaceuticals LLC), OXAPROZIN (Apotex Corp.), OXAPROZIN (AvKARE), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (California Pharmaceutical LLC), OXAPROZIN (California Pharmaceuticals LLC), OXAPROZIN (Caraco Pharmaceutical Laboratories), OXAPROZIN (Carilion Materials Management), OXAPROZIN (DIRECT RX), OXAPROZIN (Dispensing Solutions), OXAPROZIN (Dr. Reddy's Laboratories Limited), OXAPROZIN (Eon Labs), OXAPROZIN (Greenstone LLC), OXAPROZIN (H.J. Harkins Company), OXAPROZIN (PD-Rx Pharmaceuticals), OXAPROZIN (Physicians Total Care), OXAPROZIN (Preferred Pharmaceuticals), OXAPROZIN (Rebel Distributors Corp), OXAPROZIN (Teva Pharmaceuticals USA), OXAPROZIN (Unit Dose Services)
Formula
C18H15NO3
Exact mass
293.1052
Mol weight
293.3166
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01908  Antiinflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01908  Antiinflammatory drug, propionic acid derivatives
Remark
Same as: C07356
Therapeutic category: 1149
ATC code: M01AE12
Product: D00463<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Structure map
map07112  1,2-Diphenyl substitution family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE12 Oxaprozin
      D00463  Oxaprozin (JP17/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Oxaprozin
    D00463  Oxaprozin (JP17/USAN/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Oxaprozin
    D00463  Oxaprozin (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00463  Oxaprozin (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00463  Oxaprozin (JP17/USAN/INN) <JP/US>
    PTGS2 (COX2)
     D00463  Oxaprozin (JP17/USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00463  Oxaprozin
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00463
 Anesthetics, analgesics and anti-inflammatory drugs
  D00463
BRITE hierarchy
Other DBs
CAS: 21256-18-8
PubChem: 7847529
ChEBI: 7822
ChEMBL: CHEMBL1071
DrugBank: DB00991
LigandBox: D00463
NIKKAJI: J10.781F
KCF data Show

ATOM        22
            1   C8y C    25.8557  -17.0142
            2   C1b C    27.2577  -17.0142
            3   N5x N    25.0145  -15.8927
            4   C8y C    23.7060  -16.3132
            5   C8y C    23.7060  -17.7152
            6   O2x O    25.0145  -18.1358
            7   C8x C    20.0609  -14.2103
            8   C8x C    20.0609  -15.6123
            9   C8x C    21.2760  -16.3132
            10  C8y C    22.4910  -15.6123
            11  C8x C    22.4910  -14.2103
            12  C8x C    21.2760  -13.5093
            13  C8x C    20.0609  -18.4162
            14  C8x C    20.0609  -19.8181
            15  C8x C    21.2760  -20.5191
            16  C8x C    22.4910  -19.8181
            17  C8y C    22.4910  -18.4162
            18  C8x C    21.2760  -17.7152
            19  C1b C    27.9586  -15.8000
            20  C6a C    29.3606  -15.8000
            21  O6a O    30.0620  -14.5852
            22  O6a O    30.0612  -17.0135
BOND        24
            1     1   2 1
            2     1   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    7  12 1
            13   10   4 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   13  18 1
            20   17   5 1
            21    2  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 2

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