KEGG   DRUG: D00470Help
Entry
D00470                      Drug                                   

Name
Prazepam (JP16/USAN/INN);
Centrax (TN)
Formula
C19H17ClN2O
Exact mass
324.1029
Mol weight
324.8041
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Same as: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA11 Prazepam
      D00470  Prazepam (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Prazepam
      D00470  Prazepam (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00470  Prazepam
  D00470  Prazepam tablets
BRITE hierarchy
Other DBs
CAS: 
2955-38-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C2y C    18.4100  -14.9800
            2   C8y C    17.5700  -13.8600
            3   C8y C    17.9200  -12.5300
            4   N1y N    19.1800  -11.9700
            5   N2x N    19.8100  -14.9800
            6   C5x C    20.4400  -12.6000
            7   C1x C    20.7200  -13.9300
            8   C8x C    16.8700  -11.5500
            9   C8x C    15.5400  -11.9700
            10  C8y C    15.1900  -13.3000
            11  C8x C    16.2400  -14.2800
            12  O5x O    21.4900  -11.6200
            13  X   Cl   13.8600  -13.7200
            14  C8y C    17.7800  -16.2400
            15  C8x C    16.3800  -16.2400
            16  C1b C    19.1800  -10.5700
            17  C1y C    20.3700   -9.8700
            18  C8x C    15.6800  -17.4300
            19  C8x C    16.3800  -18.6900
            20  C8x C    17.7800  -18.6900
            21  C8x C    18.4800  -17.4300
            22  C1x C    22.0500   -9.8700
            23  C1x C    21.2100   -8.4000
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17    4  16 1
            18   16  17 1
            19   15  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   14  21 2
            24   17  22 1
            25   17  23 1
            26   22  23 1

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