KEGG   DRUG: PrednisoneHelp
Entry
D00473                      Drug                                   

Name
Prednisone (USP);
Prednisone monohydrate;
Deltasone (TN);
Meticorten (TN);
Rayos (TN)
Product
  Generic
PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (A-S Medication Solutions LLC), PREDNISONE (ASE Direct), PREDNISONE (Actavis Pharma), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (American Health Packaging), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Apotheca), PREDNISONE (Apotheca), PREDNISONE (Atlantic Biologicals Corps), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Blenheim Pharmacal), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (C.O. Truxton), PREDNISONE (Cardinal Health), PREDNISONE (Cardinal Health), PREDNISONE (Carilion Materials Management), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (Department of State Health Services), PREDNISONE (Department of State Health Services), PREDNISONE (Direct Rx), PREDNISONE (DirectRX), PREDNISONE (Dispensing Solutions), PREDNISONE (Dispensing Solutions), PREDNISONE (Dispensing Solutions), PREDNISONE (Dispensing Solutions), PREDNISONE (Dispensing Solutions), PREDNISONE (Golden State Medical Supply), PREDNISONE (H.J. Harkins Company), PREDNISONE (H.J. Harkins Company), PREDNISONE (H.J. Harkins Company), PREDNISONE (Hikma Pharmaceutical), PREDNISONE (JUBILANT CADISTA PHARMACEUTICALS), PREDNISONE (JUBILANT CADISTA PHARMACEUTICALS), PREDNISONE (Keltman Pharmaceuticals), PREDNISONE (Lake Erie Medical & Surgial Supply DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie medical DBA Quality Care Products LLC), PREDNISONE (Liberty Pharmaceuticals), PREDNISONE (Liberty Pharmaceuticals), PREDNISONE (McKesson Contract Packaging), PREDNISONE (McKesson Packaging Services a business unit of McKesson Corporation), PREDNISONE (McKesson Packaging Services a business unit or McKesson Corporation), PREDNISONE (MedVantx), PREDNISONE (Medsource Pharmaceuticals), PREDNISONE (Medsource Pharmaceuticals), PREDNISONE (NCS HealthCare of KY), PREDNISONE (Northwind Pharmaceuticals), PREDNISONE (Northwind Pharmaceuticals), PREDNISONE (Northwind Pharmaceuticals), DELTASONE (Oculus Innovative Sciences), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (Perrigo New York), PREDNISONE (Perrigo New York), PERRIGO PREDNISONE (Perrigo Pharmaceuticals Company), PERRIGO PREDNISONE (Perrigo Pharmaceuticals Company), PERRIGO PREDNISONE (Perrigo Pharmaceuticals Company), PREDNISONE (Physicians Total Care), PREDNISONE (Physicians Total Care), PREDNISONE (Physicians Total Care), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Qualitest Pharmaceuticals), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (Rebel Distributors Corp), PREDNISONE (Rebel Distributors Corp), PREDNISONE (Rebel Distributors Corp), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (STAT RX USA LLC), PREDNISONE (STAT Rx USA LLC), PREDNISONE (STAT Rx USA LLC), PREDNISONE (STAT Rx USA LLC), PREDNISONE (Safecor Health), PREDNISONE (St Marys Medical Park Pharmacy), PREDNISONE (State of Florida DOH Central Pharmacy), PREDNISONE (State of Florida DOH Central Pharmacy), PREDNISONE (TYA Pharmaceuticals), PREDNISONE (Unit Dose Services), PREDNISONE (Unit Dose Services), PREDNISONE (Unit Dose Services), PREDNISONE (West-Ward Pharmaceuticals Corp), PREDNISONE (West-Ward Pharmaceuticals Corp), PREDNISONE (West-Ward Pharmaceuticals Corp.)
Formula
C21H26O5. H2O
Exact mass
376.1886
Mol weight
376.4434
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Remark
ATC code: 
Chemical group: 
Activity
Glucocorticoid
Target
glucocorticoid receptor [HSA:2908] [KO:K05771]
  Pathway
Neuroactive ligand-receptor interaction
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551], CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antineoplastics - hormones
Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA03 Prednisone
      D00473  Prednisone (USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB07 Prednisone
      D00473  Prednisone (USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisone
   D00473  Prednisone (USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisone
    D00473  Prednisone (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    glucocorticoid receptor
     Prednisone
      D00473  Prednisone (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP2C19
   Prednisone
    D00473  Prednisone (USP)
  CYP3A
   Prednisone
    D00473  Prednisone (USP)
Antineoplastics [br08340.html]
 D00473
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00473
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        27
            1   C2x C     4.2529  -10.3884
            2   C5x C     4.2529  -11.7514
            3   C2x C     5.4333  -12.4329
            4   C2y C     6.6137  -11.7514
            5   C1z C     6.6137  -10.3884
            6   C2x C     5.4333   -9.7068
            7   C1x C     7.7941  -12.4329
            8   C1x C     8.9745  -11.7514
            9   C1y C     8.9745  -10.3884
            10  C1y C     7.7941   -9.7068
            11  C1y C    10.1550   -9.7068
            12  C1z C    10.1550   -8.3438
            13  C1x C     8.9745   -7.6623
            14  C5x C     7.7941   -8.3438
            15  C1x C    12.5157   -9.7068
            16  C1x C    12.5157   -8.3438
            17  C1z C    11.3354   -7.6623
            18  O5x O     3.0725  -12.4329
            19  C1a C     6.6137   -9.0253
            20  O5x O     6.6157   -7.6635
            21  C1a C    10.1550   -6.9808
            22  C5a C    11.3354   -6.0948
            23  O1a O    12.5157   -6.9808
            24  C1b C    12.5197   -5.4111
            25  O5a O    10.1589   -5.4155
            26  O1a O    13.6856   -6.0843
            27  O0  O    15.8200   -9.8700
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 2
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1

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