KEGG   DRUG: D00477Help
Entry
D00477                      Drug                                   

Name
Procainamide hydrochloride (JP16/USP);
Procan SR (TN);
Procanbid (TN);
Pronestyl (TN)
Product
  Generic
Formula
C13H21N3O. HCl
Exact mass
271.1451
Mol weight
271.7863
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A3 [HSA:6581]
Interaction
Transporter inhibition: SLC47A1 [HSA:55244]
Drug interaction
Structure map
Antipsychotics
Antiarrhythmic drugs
Dopamine receptor agonists/antagonists
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA02 Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Procainamide
    D00477  Procainamide hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2121  Procainamides
     D00477  Procainamide hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Procainamide
      D00477  Procainamide hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00477  Procainamide hydrochloride
  D00477  Procainamide hydrochloride tablets
  D00477  Procainamide hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 
614-39-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    18.9171  -15.8141
            2   C5a C    20.1248  -16.5201
            3   C8x C    18.9231  -14.4081
            4   C8x C    17.6921  -16.5084
            5   N1b N    21.3384  -15.8257
            6   O5a O    20.1190  -17.9203
            7   C8x C    17.7154  -13.6964
            8   C8x C    16.4902  -15.7966
            9   C1b C    22.5518  -16.5258
            10  C8y C    16.5018  -14.4022
            11  C1b C    23.7594  -15.8317
            12  N1a N    15.2884  -13.6906
            13  N1c N    24.9728  -16.5318
            14  C1b C    26.1805  -15.8433
            15  C1b C    24.9671  -17.9320
            16  C1a C    27.3941  -16.5375
            17  C1a C    26.1747  -18.6437
            18  X   Cl   30.9992  -17.3018
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     7  10 2
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  10 1

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