KEGG   DRUG: D00480Help
Entry
D00480                      Drug                                   

Name
Promethazine hydrochloride (JP16/USP);
Phenergan (TN);
Promethegan (TN)
Product
  Generic
PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals), PROMETHAZINE HCL (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions LLC), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions LLC), PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions LLC), PROMETHAZINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), PROMETHAZINE HYDROCHLORIDE (American Health Packaging), PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Atlantic Biologicals Corps), PROMETHAZINE HYDROCHLORIDE (BAXTER HEALTHCARE CORPORATION), PHENERGAN (Baxter Healthcare Corporation), PROMETHAZINE HYDROCHLORIDE (Blenheim Pharmacal), PROMETHAZINE HYDROCHLORIDE (BluePoint Laboratories), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Cadila Healthcare Limited), PROMETHAZINE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), PROMETHAZINE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Clinical Solutions Wholesale), PROMETHAZINE HYDROCHLORIDE (Clinical Solutions Wholesale), PROMETHAZINE HYDROCHLORIDE (Dispensing Solutions), PROMETHAZINE HYDROCHLORIDE (Dispensing Solutions), PROMETHAZINE HYDROCHLORIDE (Dispensing Solutions), PROMETHEGAN (G & W LABORATORIES), PROMETHEGAN (GW Laboratories), PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines), PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines), PROMETHAZINE HYDROCHLORIDE (Global Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Golden State Medical Supply), PROMETHAZINE HYDROCHLORIDE (H.J. Harkins Company), PROMETHEGAN (H.J. Harkins Company), PROMETHAZINE HYDROCHLORIDE (Hi-Tech Pharmacal), PROMETHAZINE HYDROCHLORIDE (Hospira), PROMETHAZINE HYDROCHLORIDE (Hospira), PROMETHAZINE HYDROCHLORIDE (KVK-Tech), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Liberty Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Life Line Home Care Services), PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (McKesson Contract Packaging), PROMETHAZINE HYDROCHLORIDE (McKesson Contract Packaging), PROMETHAZINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), PROMETHAZINE HYDROCHLORIDE (MedVantx), PROMETHAZINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Mylan Institutional), PROMETHAZINE HYDROCHLORIDE (NCS HealthCare of KY), PROMETHAZINE (NCS HealthCare of KY), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENADOZ (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHEGAN (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENADOZ (Paddock Laboratories), PROMETHAZINE HYDROCHLORIDE (Perrigo New York), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHAZINE (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHEGAN (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Qualitest Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Qualitest Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PHENADOZ (REMEDYREPACK), PROMETHEGAN (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (ReadyMeds), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHEGAN (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (STAT RX USA LLC), PROMETHAZINE HYDROCHLORIDE (STAT Rx USA LLC), PROMETHAZINE HYDROCHLORIDE (STAT Rx USA LLC), PROMETHAZINE HYDROCHLORIDE (Sandoz), PROMETHAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROMETHAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROMETHAZINE HYDROCHLORIDE (Teva Parenteral Medicines), PROMETHAZINE HYDROCHLORIDE (Unit Dose Services), PROMETHAZINE HYDROCHLORIDE (Watson Laboratories), PHENADOZ (Watson Laboratories), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PHENERGAN (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PHENERGAN (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
  Other
Formula
C17H20N2S. HCl
Exact mass
320.1114
Mol weight
320.88
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic;
Antihistaminic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antipsychotics
Phenothiazines
Hypnotics
Histamine H1 receptor antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D00480  Promethazine hydrochloride (JP16/USP)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D00480  Promethazine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Promethazine
    D00480  Promethazine hydrochloride (JP16/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Promethazine
    D00480  Promethazine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D00480  Promethazine hydrochloride (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Specified Category 2
  Inorganic and organic chemicals
   Promethazine
    D00480  Promethazine hydrochloride (JP16/USP)
 Category 2
  Inorganic and organic chemicals
   Promethazine
    D00480  Promethazine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Promethazine
      D00480  Promethazine hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Promethazine
    D00480  Promethazine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00480  Promethazine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
58-33-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   N1y N    24.1512  -19.0928
            2   C8y C    25.3914  -19.7915
            3   C8y C    22.9575  -19.7915
            4   C1b C    24.1512  -17.6779
            5   C8y C    25.3914  -21.1947
            6   C8x C    26.5851  -19.0928
            7   C8y C    22.9575  -21.1947
            8   C8x C    21.7580  -19.0928
            9   C1c C    25.3565  -16.9850
            10  S2x S    24.1512  -21.8934
            11  C8x C    26.5851  -21.8934
            12  C8x C    27.7904  -19.7915
            13  C8x C    21.7580  -21.8934
            14  C8x C    20.5179  -19.7915
            15  N1c N    25.3565  -15.6691
            16  C1a C    26.5442  -17.6779
            17  C8x C    27.7904  -21.1947
            18  C8x C    20.5179  -21.1947
            19  C1a C    24.0173  -14.8947
            20  C1a C    26.4919  -14.9296
            21  X   Cl   30.1777  -19.5178
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1

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