KEGG   DRUG: Promethazine hydrochlorideHelp
Entry
D00480                      Drug                                   

Name
Promethazine hydrochloride (JP17/USP);
Phenergan (TN);
Promethegan (TN)
Product
  Generic
PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York), PROMETHAZINE HYDROCHLORIDE (Actavis Pharma), PHENADOZ (Actavis Pharma), PROMETHAZINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), PROMETHAZINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), PROMETHAZINE HYDROCHLORIDE (American Health Packaging), PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Apotheca), PROMETHAZINE HYDROCHLORIDE (Atlantic Biologicals Corps), PROMETHAZINE HYDROCHLORIDE (Blenheim Pharmacal), PROMETHAZINE HYDROCHLORIDE (Blenheim Pharmacal), PROMETHAZINE HYDROCHLORIDE (Blenheim Pharmacal), PROMETHAZINE HYDROCHLORIDE (Blenheim Pharmacal), PROMETHAZINE HYDROCHLORIDE (BluePoint Laboratories), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack), PROMETHAZINE HYDROCHLORIDE (Cadila Healthcare Limited), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Cardinal Health), PROMETHAZINE HYDROCHLORIDE (Carilion Materials Management), PROMETHAZINE HYDROCHLORIDE (Clinical Solutions Wholesale), PROMETHAZINE HYDROCHLORIDE (DIERCT RX), PROMETHAZINE HYDROCHLORIDE (DIERCT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (DIRECT RX), PROMETHAZINE HYDROCHLORIDE (Dispensing Solutions), PROMETHAZINE HYDROCHLORIDE (Dispensing Solutions), PROMETHAZINE HYDROCHLORIDE (Dispensing Solutions), PROMETHEGAN (G&W Laboratories), PROMETHEGAN (G&W Laboratories), PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines), PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines), PROMETHAZINE HYDROCHLORIDE (Golden State Medical Supply), PROMETHAZINE HYDROCHLORIDE (H.J. Harkins Company), PROMETHEGAN (H.J. Harkins Company), PROMETHAZINE HYDROCHLORIDE (Heritage Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Hi-Tech Pharmacal), PROMETHAZINE HYDROCHLORIDE (KVK-Tech), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROMETHAZINE HYDROCHLORIDE (Liberty Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Liberty Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Life Line Home Care Services), PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Marlex Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (McKesson Corporation), PROMETHAZINE HYDROCHLORIDE (MedVantx), PROMETHAZINE HYDROCHLORIDE (Medical Purchasing Solutions), PROMETHAZINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Mylan Institutional), PROMETHAZINE HYDROCHLORIDE (NCS HealthCare of KY), PROMETHAZINE (NCS HealthCare of KY), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Nostrum Laboratories), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHEGAN (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROMETHAZINE (PD-Rx Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Par Pharmaceutical), PROMETHAZINE HYDROCHLORIDE (Perrigo New York), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHAZINE (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHEGAN (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Physicians Total Care), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceutical), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENERGAN (Prestium Pharma), PHENERGAN (Prestium Pharma), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP), PROMETHAZINE HYDROCHLORIDE (QPharma), PROMETHAZINE HYDROCHLORIDE (QPharma), PROMETHAZINE HYDROCHLORIDE (Qualitest Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK), PROMETHAZINE HYDROCHLORIDE (ReadyMeds), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (Rebel Distributors Corp), PROMETHEGAN (Rebel Distributors Corp), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (RedPharm Drug), PROMETHAZINE HYDROCHLORIDE (Renaissance Pharma), PROMETHAZINE HYDROCHLORIDE (Renaissance Pharma), PROMETHAZINE HYDROCHLORIDE (Sandoz), PROMETHAZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROMETHAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROMETHAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROMETHAZINE HYDROCHLORIDE (Strides Shasun Limited), PROMETHAZINE HYDROCHLORIDE (Sun Pharmaceutical Industries), PROMETHAZINE HYDROCHLORIDE (TYA Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (TYA Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), PROMETHAZINE HYDROCHLORIDE (Unit Dose Services), PROMETHAZINE HYDROCHLORIDE (Unit Dose Services), PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PHENERGAN (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PHENERGAN (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PROMETHAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.), PROMETHAZINE HCL (Wockhardt USA LLC.), PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals), PROMETHAZINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), PROMETHAZINE HYDROCHLORIDE (Direct Rx), PHENERGAN (DIRECT RX)
  Other
Formula
C17H20N2S. HCl
Exact mass
320.1114
Mol weight
320.88
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 4413
ATC code: D04AA10 R06AD02
Chemical structure group: DG00385
Product (DG00385): D00480<JP/US> D03290<JP> D08768<JP>
Efficacy
Antiallergic, Anti-emetic, Antiparkinsonian, H1 receptor antagonist
  Disease
Perennial and seasonal allergic rhinitis [DS:H01360]
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA10 Promethazine
      D00480  Promethazine hydrochloride (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD02 Promethazine
      D00480  Promethazine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Promethazine
    D00480  Promethazine hydrochloride (JP17/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Promethazine
    D00480  Promethazine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D00480  Promethazine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D00480  Promethazine hydrochloride (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Promethazine
    D00480  Promethazine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00480  Promethazine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00480  Promethazine hydrochloride
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00480
 Anti-allergic agents
  D00480
 Gastrointestinal agents
  D00480
BRITE hierarchy
Other DBs
CAS: 58-33-3
PubChem: 7847546
ChEBI: 8462
ChEMBL: CHEMBL1200750
DrugBank: DB01069
LigandBox: D00480
NIKKAJI: J371.970G
KCF data Show

ATOM        21
            1   N1y N    24.1512  -19.0928
            2   C8y C    25.3914  -19.7915
            3   C8y C    22.9575  -19.7915
            4   C1b C    24.1512  -17.6779
            5   C8y C    25.3914  -21.1947
            6   C8x C    26.5851  -19.0928
            7   C8y C    22.9575  -21.1947
            8   C8x C    21.7580  -19.0928
            9   C1c C    25.3565  -16.9850
            10  S2x S    24.1512  -21.8934
            11  C8x C    26.5851  -21.8934
            12  C8x C    27.7904  -19.7915
            13  C8x C    21.7580  -21.8934
            14  C8x C    20.5179  -19.7915
            15  N1c N    25.3565  -15.6691
            16  C1a C    26.5442  -17.6779
            17  C8x C    27.7904  -21.1947
            18  C8x C    20.5179  -21.1947
            19  C1a C    24.0173  -14.8947
            20  C1a C    26.4919  -14.9296
            21  X   Cl   30.1777  -19.5178
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1

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