KEGG   DRUG: D00481Help
Entry
D00481                      Drug                                   

Name
Propantheline bromide (JP16/USP/INN);
Pro-banthine (TN)
Product
  Generic
Formula
C23H30NO3. Br
Exact mass
447.1409
Mol weight
448.3932
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiulcer drugs
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    A03AB Synthetic anticholinergics, quaternary ammonium compounds
     A03AB05 Propantheline
      D00481  Propantheline bromide (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1231  Quaternary ammoniums
     D00481  Propantheline bromide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Propantheline
      D00481  Propantheline bromide (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00481  Propantheline bromide
BRITE hierarchy
Other DBs
CAS: 
50-34-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   X   Br   29.5355  -11.2850 #-
            2   C8x C    19.5645   -9.5721
            3   C8x C    19.5645  -10.9775
            4   C8x C    20.7816  -11.6802
            5   C8y C    21.9987  -10.9775
            6   C8y C    21.9987   -9.5721
            7   C8x C    20.7816   -8.8695
            8   O2x O    23.2157  -11.6802
            9   C8y C    24.4328  -10.9775
            10  C8y C    24.4328   -9.5721
            11  C1y C    23.2157   -8.8695
            12  C8x C    25.6499  -11.6802
            13  C8x C    26.8669  -10.9775
            14  C8x C    26.8669   -9.5721
            15  C8x C    25.6499   -8.8695
            16  C7a C    23.2157   -7.4641
            17  O7a O    24.4349   -6.7602
            18  O6a O    22.0007   -6.7626
            19  C1b C    25.6359   -7.4539
            20  C1b C    26.8273   -6.7661
            21  N1d N    28.0233   -7.4569 #+
            22  C1a C    28.0233   -8.8692
            23  C1c C    28.0233   -6.0515
            24  C1a C    29.2172   -5.3621
            25  C1c C    29.4233   -7.4569
            26  C1a C    26.7796   -5.3340
            27  C1a C    30.1320   -8.6834
            28  C1a C    30.1029   -6.2792
BOND        29
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    9  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   10  15 2
            17   11  16 1
            18   16  17 1
            19   16  18 2
            20   17  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   21  23 1
            25   23  24 1
            26   21  25 1
            27   23  26 1
            28   25  27 1
            29   25  28 1

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