KEGG   DRUG: PerphenazineHelp
Entry
D00503                      Drug                                   

Name
Perphenazine (JP17/USP/INN);
Trilafon (TN)
Product
  Generic
PERPHENAZINE (American Health Packaging), PERPHENAZINE (American Health Packaging), PERPHENAZINE (Cardinal Health), PERPHENAZINE (Clinical Solutions Wholesale), PERPHENAZINE (Contract Pharmacy Services-PA), PERPHENAZINE (H.J. Harkins Company), PERPHENAZINE (NCS HealthCare of KY), PERPHENAZINE (Qualitest Pharmaceuticals), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (Rebel Distributors Corp), PERPHENAZINE (Sandoz), PERPHENAZINE (State of Florida DOH Central Pharmacy), PERPHENAZINE (State of Florida DOH Central Pharmacy), PERPHENAZINE (State of Florida DOH Central Pharmacy)
Formula
C21H26ClN3OS
Exact mass
403.1485
Mol weight
403.9686
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antipsychotic, Dopamin D2 receptor antagonist
Comment
Phenothiazine derivative
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
Neuroactive ligand-receptor interaction
Gap junction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB03 Perphenazine
      D00503  Perphenazine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Perphenazine
    D00503  Perphenazine (JP17/USP/INN)
 Antipsychotics
  1st Generation/Typical
   Perphenazine
    D00503  Perphenazine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D00503  Perphenazine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Perphenazine
      D00503  Perphenazine (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Perphenazine
    D00503  Perphenazine (JP17/USP/INN)
 CYP substrates
  CYP2D6
   Perphenazine
    D00503  Perphenazine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00503  Perphenazine
  D00503  Perphenazine tablets
Psychiatric agents [br08363.html]
 Antipsychotics
  D00503
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00503
BRITE hierarchy
Other DBs
CAS: 
58-39-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C8x C    16.1000  -11.4100
            2   C8x C    16.1000  -12.8100
            3   C8x C    17.3124  -13.5100
            4   C8y C    18.5249  -12.8100
            5   C8y C    18.5249  -11.4100
            6   C8x C    17.3124  -10.7100
            7   S2x S    19.7373  -13.5100
            8   C8y C    20.9497  -12.8100
            9   C8y C    20.9497  -11.4100
            10  N4y N    19.7373  -10.7100
            11  C8x C    22.1622  -13.5100
            12  C8x C    23.3746  -12.8100
            13  C8y C    23.3746  -11.4100
            14  C8x C    22.1622  -10.7100
            15  C1b C    19.7373   -9.3100
            16  C1b C    20.9518   -8.6088
            17  C1b C    22.1483   -9.2998
            18  N1y N    23.3351   -8.6146
            19  C1x C    24.5266   -9.3028
            20  C1x C    25.7391   -8.6029
            21  N1y N    25.7393   -7.2029
            22  C1x C    24.5478   -6.5148
            23  C1x C    23.3353   -7.2146
            24  C1b C    26.9641   -6.4958
            25  C1b C    28.1720   -7.1932
            26  O1a O    29.3532   -6.5113
            27  X   Cl   24.5911  -10.7077
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   18  23 1
            27   21  24 1
            28   24  25 1
            29   25  26 1
            30   13  27 1

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