KEGG   DRUG: D00506Help
Entry
D00506                      Drug                                   

Name
Phenobarbital (JP16/USP/INN);
Luminal (TN)
Product
  Other
PHENOBARBITAL (American Health Packaging), PHENOBARBITAL (Aphena Pharma Solutions - Tennessee), PHENOBARBITAL (Atlantic Biologicals Corps), PHENOBARBITAL (Bryant Ranch Prepack), PHENOBARBITAL (Bryant Ranch Prepack), PHENOBARBITAL (C.O. Truxton), PHENOBARBITAL (Cardinal Health), PHENOBARBITAL (Contract Pharmacy Services-PA), PHENOBARBITAL (McKesson Contract Packaging), PHENOBARBITAL (McKesson Packaging Services Business Unit of McKesson Corporation), PHENOBARBITAL (PD-Rx Pharmaceuticals), PHENOBARBITAL (Pack Pharmaceuticals), PHENOBARBITAL (Qualitest Pharmaceuticals), PHENOBARBITAL (Qualitest Pharmaceuticals), PHENOBARBITAL (West-Ward Pharmaceutical Corp), DONNATAL (Atlantic Biologicals Corps), DONNATAL (AvKARE), DONNATAL (PBM Pharmaceuticals), DONNATAL (PBM Pharmaceuticals), DONNATAL (PBM Pharmaceuticals)
Formula
C12H12N2O3
Exact mass
232.0848
Mol weight
232.2353
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant;
Sedative-hypnotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Barbiturates
Target
GABAA-receptor (picrotoxin binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A [HSA:1576 1577 1551]
Interaction
CYP induction: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter induction: ABCB1 [HSA:5243]
Drug interaction
Structure map
Hypnotics
Anticonvulsants
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AA Barbiturates and derivatives
     N03AA02 Phenobarbital
      D00506  Phenobarbital (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1125  Barbiturates and thiobarbiturates
     D00506  Phenobarbital (JP16/USP/INN)
   113  Antiepileptics
    1134  Barbiturates
     D00506  Phenobarbital (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (picrotoxin binding site)
     Phenobarbital
      D00506  Phenobarbital (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
  CYP3A
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
 Inducers
  CYP1A2
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
  CYP2B6
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
  CYP2C9
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
  CYP3A4
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
  CYP3A5
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
  CYP3A7
   Phenobarbital
    D00506  Phenobarbital (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00506  Phenobarbital
  D00506  10% Phenobarbital powder
BRITE hierarchy
Other DBs
CAS: 
50-06-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C1z C    24.5688  -19.5768
            2   C8y C    25.7739  -18.8690
            3   C5x C    23.3288  -18.8924
            4   C5x C    24.5688  -20.9807
            5   C1b C    25.7679  -20.2728
            6   C8x C    26.9847  -19.5534
            7   C8x C    25.7562  -17.4653
            8   N1x N    22.1238  -19.5768
            9   O5x O    23.3288  -17.4770
            10  N1x N    23.3288  -21.6826
            11  O5x O    25.7621  -21.6826
            12  C1a C    27.1718  -20.2728
            13  C8x C    28.1895  -18.8457
            14  C8x C    26.9612  -16.7574
            15  C5x C    22.1238  -20.9807
            16  C8x C    28.1778  -17.4476
            17  O5x O    20.9130  -21.6766
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    4  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   13  16 2
            16   15  17 2
            17   10  15 1
            18   14  16 1

» Japanese version   » Back

DBGET integrated database retrieval system