KEGG   DRUG: PindololHelp
Entry
D00513                      Drug                                   

Name
Pindolol (JP17/USP/INN);
Blocklin-L (TN);
Carvisken (TN);
Visken (TN)
Product
  Generic
Formula
C14H20N2O2
Exact mass
248.1525
Mol weight
248.3208
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antiarrhythmic, Antihypertensive, Vasodilator, beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA03 Pindolol
      D00513  Pindolol (JP17/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Pindolol
    D00513  Pindolol (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00513  Pindolol (JP17/USP/INN)
   214  Antihypertensives
    2149  Others
     D00513  Pindolol (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Pindolol
      D00513  Pindolol (JP17/USP/INN)
    beta2-adrenergic receptor
     Pindolol
      D00513  Pindolol (JP17/USP/INN)
    beta3-adrenergic receptor
     Pindolol
      D00513  Pindolol (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Pindolol
    D00513  Pindolol (JP17/USP/INN)
 Transporter substrates
  SLC22A2
   Pindolol
    D00513  Pindolol (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00513  Pindolol
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00513
BRITE hierarchy
Other DBs
CAS: 
13523-86-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    18.9000  -17.2200
            2   C8y C    18.9000  -18.6200
            3   C8y C    20.1600  -16.5200
            4   C8x C    17.5700  -16.8000
            5   N4x N    17.5700  -19.1100
            6   C8x C    20.1600  -19.3200
            7   C8x C    21.3500  -17.2200
            8   O2a O    20.1600  -15.1200
            9   C8x C    16.8000  -17.9200
            10  C8x C    21.3500  -18.6200
            11  C1b C    21.3500  -14.4200
            12  C1c C    22.5400  -15.1200
            13  C1b C    23.8000  -14.4200
            14  O1a O    22.5400  -16.5200
            15  N1b N    24.9900  -15.1200
            16  C1c C    26.1800  -14.4200
            17  C1a C    27.4400  -15.1200
            18  C1a C    26.1800  -13.0200
BOND        19
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     6  10 2
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18    5   9 1
            19    7  10 1

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