KEGG   DRUG: ChlorothiazideHelp
Entry
D00519                      Drug                                   

Name
Chlorothiazide (JAN/USP/INN);
Diuril (TN)
Product
  Generic
Formula
C7H6ClN3O4S2
Exact mass
294.9488
Mol weight
295.7232
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01749  Thiazide diuretic
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
Comment
Thiazides
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Sulfonamide derivatives - overview
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA04 Chlorothiazide
      D00519  Chlorothiazide (JAN/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Chlorothiazide
    D00519  Chlorothiazide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3
     Chlorothiazide
      D00519  Chlorothiazide (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
58-94-6
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    19.8889  -15.0612
            2   C8y C    19.8946  -16.4185
            3   C8x C    21.0648  -14.3768
            4   S2x S    18.7070  -14.3943
            5   C8x C    21.0705  -17.0914
            6   N5x N    18.7304  -17.1088
            7   C8y C    22.2407  -15.0495
            8   N4x N    17.5371  -15.0846
            9   O3c O    17.3849  -13.5811
            10  O3c O    19.9298  -13.5577
            11  C8y C    22.2465  -16.4068
            12  C8x C    17.5488  -16.4419
            13  S4a S    23.4166  -14.3651
            14  X   Cl   23.4283  -17.0797
            15  N1a N    24.6568  -13.5168
            16  O3c O    24.5457  -15.3714
            17  O3c O    22.3284  -13.3295
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 2
            11    6  12 2
            12    7  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   13  17 2
            17    7  11 1
            18    8  12 1

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