KEGG   DRUG: D00520Help
Entry
D00520                      Drug                                   

Name
Dimenhydrinate (JP16/USP/INN);
Dramamine (TN)
Product
  Generic
Formula
C17H21NO. C7H7ClN4O2
Exact mass
469.1881
Mol weight
469.9638
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic
Remark
Therapeutic category: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   133  Vertigo agents
    1331  Dimenhydrinates
     D00520  Dimenhydrinate (JP16/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00520  Dimenhydrinate (JP16/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dimenhydrinate
    D00520  Dimenhydrinate (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dimenhydrinate
      D00520  Dimenhydrinate (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00520  Dimenhydrinate
  D00520  Dimenhydrinate tablets
BRITE hierarchy
Other DBs
CAS: 
523-87-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C8y C    24.0335  -15.5458
            2   C8y C    24.0335  -16.9748
            3   C8y C    25.2341  -14.8371
            4   N4x N    22.7217  -15.1124
            5   N4y N    25.2341  -17.6599
            6   N5x N    22.7217  -17.4080
            7   N4y N    26.4579  -15.5750
            8   O5x O    25.2341  -13.4551
            9   C8y C    21.9077  -16.2720
            10  C8y C    26.4579  -16.9220
            11  C1a C    25.2341  -19.0946
            12  C1a C    27.7111  -14.8957
            13  X   Cl   20.5022  -16.2778
            14  O5x O    27.7111  -17.6248
            15  C1c C    13.1842  -16.5304
            16  C8y C    11.9719  -17.2389
            17  C8y C    14.4022  -17.2389
            18  O2a O    13.1900  -15.1308
            19  C8x C    11.9719  -18.6326
            20  C8x C    10.7597  -16.5304
            21  C8x C    14.3965  -18.6326
            22  C8x C    15.6088  -16.5304
            23  C1b C    14.4022  -14.4280
            24  C8x C    10.7597  -19.3296
            25  C8x C     9.5475  -17.2389
            26  C8x C    15.6088  -19.3296
            27  C8x C    16.8209  -17.2389
            28  C8x C     9.5475  -18.6326
            29  C8x C    16.8150  -18.6326
            30  C1b C    15.6064  -15.1220
            31  N1c N    16.7880  -14.4384
            32  C1a C    17.9856  -15.1287
            33  C1a C    16.7870  -13.0368
BOND        35
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    7  12 1
            12    9  13 1
            13   10  14 2
            14    6   9 2
            15    7  10 1
            16   15  16 1
            17   15  17 1
            18   15  18 1
            19   16  19 1
            20   16  20 2
            21   17  21 2
            22   17  22 1
            23   18  23 1
            24   19  24 2
            25   20  25 1
            26   21  26 1
            27   22  27 2
            28   24  28 1
            29   26  29 2
            30   25  28 2
            31   27  29 1
            32   23  30 1
            33   30  31 1
            34   31  32 1
            35   31  33 1

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