KEGG   DRUG: D00520Help
Entry
D00520                      Drug                                   
Name
Dimenhydrinate (JP16/USP/INN);
Dramamine (TN)
Product
  Generic
Formula
C17H22NO. C7H6ClN4O2
Exact mass
469.1881
Mol weight
469.9638
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic
Remark
Therapeutic category: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   133  Vertigo agents
    1331  Dimenhydrinates
     D00520  Dimenhydrinate (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Dimenhydrinate
      D00520  Dimenhydrinate (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
523-87-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C8y C    35.1187  -15.5260
            2   C8y C    35.1187  -16.9532
            3   C8y C    36.3177  -14.8182
            4   N4x N    33.8086  -15.0931 #-
            5   N4y N    36.3177  -17.6374
            6   N5x N    33.8086  -17.3858
            7   N4y N    37.5400  -15.5551
            8   O5x O    36.3177  -13.4379
            9   C8y C    32.9956  -16.2513
            10  C8y C    37.5400  -16.9004
            11  C1a C    36.3177  -19.0703
            12  C1a C    38.7916  -14.8767
            13  X   Cl   31.5919  -16.2571
            14  O5x O    38.7916  -17.6023
            15  C1c C    24.2832  -16.5093
            16  C8y C    23.0725  -17.2169
            17  C8y C    25.4997  -17.2169
            18  O2a O    24.2890  -15.1115
            19  C8x C    23.0725  -18.6089
            20  C8x C    21.8618  -16.5093
            21  C8x C    25.4940  -18.6089
            22  C8x C    26.7047  -16.5093
            23  C1b C    25.4997  -14.4096
            24  C8x C    21.8618  -19.3050
            25  C8x C    20.6511  -17.2169
            26  C8x C    26.7047  -19.3050
            27  C8x C    27.9153  -17.2169
            28  C8x C    20.6511  -18.6089
            29  C8x C    27.9094  -18.6089
            30  C1b C    26.7023  -15.1027
            31  N1c N    27.8824  -14.4200 #+
            32  C1a C    29.0785  -15.1094
            33  C1a C    27.8814  -13.0202
BOND        35
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    7  12 1
            12    9  13 1
            13   10  14 2
            14    6   9 2
            15    7  10 1
            16   15  16 1
            17   15  17 1
            18   15  18 1
            19   16  19 1
            20   16  20 2
            21   17  21 2
            22   17  22 1
            23   18  23 1
            24   19  24 2
            25   20  25 1
            26   21  26 1
            27   22  27 2
            28   24  28 1
            29   26  29 2
            30   25  28 2
            31   27  29 1
            32   23  30 1
            33   30  31 1
            34   31  32 1
            35   31  33 1

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