KEGG   DRUG: D00522Help
Entry
D00522                      Drug                                   

Name
Candesartan (USAN/INN)
Formula
C24H20N6O3
Exact mass
440.1597
Mol weight
440.454
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antagonist [angiotensin II receptor];
Antihypertensive
Remark
Same as: 
ATC code: 
Drug group: 
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA06 Candesartan
      D00522  Candesartan (USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Candesartan
    D00522  Candesartan (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Candesartan
      D00522  Candesartan (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Candesartan
    D00522  Candesartan (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
139481-59-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C8y C    22.0850  -15.5109
            2   N4y N    21.6416  -14.1867
            3   C8y C    23.4790  -15.5166
            4   C8y C    21.3850  -16.7182
            5   C8y C    22.7790  -13.3526
            6   C1b C    20.4167  -13.4984
            7   N5x N    23.9165  -14.1867
            8   C8x C    24.1731  -16.7241
            9   C8x C    22.0790  -17.9257
            10  C6a C    20.6733  -17.9199
            11  O2a O    22.7790  -11.9526
            12  C8y C    19.2150  -14.2217
            13  C8x C    23.4731  -17.9316
            14  O6a O    19.2733  -17.9082
            15  O6a O    21.3557  -19.1331
            16  C1b C    23.9922  -11.2526
            17  C8x C    17.9842  -13.5392
            18  C8x C    19.2441  -15.5984
            19  C1a C    23.9922   -9.8526
            20  C8x C    16.7826  -14.2625
            21  C8x C    18.0309  -16.3450
            22  C8y C    16.8176  -15.6625
            23  C8y C    15.6102  -16.3799
            24  C8y C    14.3794  -15.7032
            25  C8x C    15.6335  -17.7798
            26  C8y C    14.3560  -14.2975
            27  C8x C    13.1836  -16.4208
            28  C8x C    14.4318  -18.5032
            29  N4x N    13.2243  -13.4925
            30  N5x N    15.4877  -13.4517
            31  C8x C    13.2127  -17.8265
            32  N5x N    13.6327  -12.1509
            33  N5x N    15.0326  -12.1277
BOND        37
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 1
            14   10  15 2
            15   11  16 1
            16   12  17 1
            17   12  18 2
            18   16  19 1
            19   17  20 2
            20   18  21 1
            21   20  22 1
            22   22  23 1
            23   23  24 1
            24   23  25 2
            25   24  26 1
            26   24  27 2
            27   25  28 1
            28   26  29 1
            29   26  30 2
            30   27  31 1
            31   29  32 1
            32   30  33 1
            33    5   7 2
            34    9  13 1
            35   21  22 2
            36   28  31 2
            37   32  33 2

» Japanese version   » Back

DBGET integrated database retrieval system