KEGG   DRUG: D00523Help
Entry
D00523                      Drug                                   

Name
Irbesartan (JAN/USAN/INN);
Avapro (TN)
Product
  Generic
Formula
C25H28N6O
Exact mass
428.2325
Mol weight
428.5294
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive [angiotensin II receptor antagonist]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA04 Irbesartan
      D00523  Irbesartan (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Irbesartan
    D00523  Irbesartan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00523  Irbesartan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Irbesartan
      D00523  Irbesartan (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Irbesartan
    D00523  Irbesartan (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
138402-11-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8x C     5.1800  -12.9500
            2   C8x C     5.1800  -14.3500
            3   C8x C     6.3924  -15.0500
            4   C8x C     7.6049  -14.3500
            5   C8y C     7.6049  -12.9500
            6   C8y C     6.3924  -12.2500
            7   C8y C     8.8360  -12.2390
            8   C8x C    10.0412  -12.9347
            9   C8x C    11.2535  -12.2346
            10  C8y C    11.2535  -10.8346
            11  C8x C    10.0483  -10.1389
            12  C8x C     8.8359  -10.8390
            13  C8y C     6.3924  -10.8502
            14  N5x N     7.5103  -10.0378
            15  N5x N     7.0831   -8.7236
            16  N5x N     5.7012   -8.7237
            17  N4x N     5.2743  -10.0381
            18  C1b C    12.4714  -10.1312
            19  N1y N    13.6834  -10.8307
            20  C5x C    13.6834  -12.2307
            21  C1z C    15.0148  -12.6634
            22  N2x N    15.8378  -11.5307
            23  C2y C    15.0148  -10.3981
            24  O5x O    12.5198  -13.0762
            25  C1b C    15.0148   -8.9981
            26  C1b C    16.1875   -8.3215
            27  C1b C    17.3902   -9.0164
            28  C1x C    14.1834  -13.7856
            29  C1x C    14.9992  -14.9234
            30  C1x C    16.3334  -14.4992
            31  C1x C    16.3422  -13.0992
            32  C1a C    18.5743   -8.3332
BOND        36
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    6  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   10  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 2
            26   19  23 1
            27   20  24 2
            28   23  25 1
            29   25  26 1
            30   26  27 1
            31   21  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   21  31 1
            36   27  32 1

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