| Entry |
|
|---|
| Name |
Irbesartan (JAN/USAN/INN);
Avapro (TN)
|
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| Product |
|
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| Generic |
IRBESARTAN (American Health Packaging), IRBESARTAN (Apotex Corp.), IRBESARTAN (Aurobindo Pharma Limited), IRBESARTAN (Camber Pharmaceuticals), IRBESARTAN (Legacy Pharmaceutical Packaging), IRBESARTAN (Lupin Pharmaceuticals), IRBESARTAN (Macleods Pharmaceuticals Limited), IRBESARTAN (Mylan Pharmaceuticals), IRBESARTAN (Qualitest Pharmaceuticals), IRBESARTAN (Roxane Laboratories), IRBESARTAN (Solco healthcare U.S.), IRBESARTAN (Teva Pharmaceuticals USA), IRBESARTAN (Watson Laboratories) |
|---|
| Formula |
C25H28N6O
|
|---|
| Exact mass |
428.2325
|
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| Mol weight |
428.5294
|
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| Structure |
     |
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| Activity |
Antihypertensive [angiotensin II receptor antagonist]
|
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
angiotensin II receptor type 1 (AT1) antagonist [HSA: 185] [KO: K04166] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
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| Interaction |
|
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| Structure map |
| Angiotensin receptor and endothelin receptor antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00523 Irbesartan (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
C09CA Angiotensin II antagonists, plain
C09CA04 Irbesartan
D00523 Irbesartan (JAN/USAN/INN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Angiotensin II Receptor Antagonists
Irbesartan
D00523 Irbesartan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Angiotensin
angiotensin II stimulates angiotensin subtype 1 (AT1) receptor [HSA:185] [KO:K04166]
Irbesartan [ATC:C09CA04]
D00523 Irbesartan (JAN/USAN/INN)
 |
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| Other DBs |
CAS: 138402-11-6 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 32
1 C8x C 5.1800 -12.9500
2 C8x C 5.1800 -14.3500
3 C8x C 6.3924 -15.0500
4 C8x C 7.6049 -14.3500
5 C8y C 7.6049 -12.9500
6 C8y C 6.3924 -12.2500
7 C8y C 8.8360 -12.2390
8 C8x C 10.0412 -12.9347
9 C8x C 11.2535 -12.2346
10 C8y C 11.2535 -10.8346
11 C8x C 10.0483 -10.1389
12 C8x C 8.8359 -10.8390
13 C8y C 6.3924 -10.8502
14 N5x N 7.5103 -10.0378
15 N5x N 7.0831 -8.7236
16 N5x N 5.7012 -8.7237
17 N4x N 5.2743 -10.0381
18 C1b C 12.4714 -10.1312
19 N1y N 13.6834 -10.8307
20 C5x C 13.6834 -12.2307
21 C1z C 15.0148 -12.6634
22 N2x N 15.8378 -11.5307
23 C2y C 15.0148 -10.3981
24 O5x O 12.5198 -13.0762
25 C1b C 15.0148 -8.9981
26 C1b C 16.1875 -8.3215
27 C1b C 17.3902 -9.0164
28 C1x C 14.1834 -13.7856
29 C1x C 14.9992 -14.9234
30 C1x C 16.3334 -14.4992
31 C1x C 16.3422 -13.0992
32 C1a C 18.5743 -8.3332
BOND 36
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 7 12 1
14 6 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 13 17 1
20 10 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 2
26 19 23 1
27 20 24 2
28 23 25 1
29 25 26 1
30 26 27 1
31 21 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 21 31 1
36 27 32 1
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