KEGG   DRUG: IrbesartanHelp
Entry
D00523                      Drug                                   

Name
Irbesartan (JP17/USAN/INN);
Avapro (TN)
Product
  Generic
IRBESARTAN (Ajanta Pharma Limited), IRBESARTAN (Alembic Pharmaceuticals), IRBESARTAN (American Health Packaging), IRBESARTAN (Apotex Corp.), IRBESARTAN (Aurobindo Pharma Limited), IRBESARTAN (AvPAK), IRBESARTAN (Bryant Ranch Prepack), IRBESARTAN (Bryant Ranch Prepack), IRBESARTAN (Camber Pharmaceuticals), IRBESARTAN (Carilion Materials Management), IRBESARTAN (Golden State Medical Supply), IRBESARTAN (Hisun Pharmaceuticals USA), IRBESARTAN (Jubilant Cadista Pharmaceuticals), IRBESARTAN (LUPIN LIMITED), IRBESARTAN (Legacy Pharmaceutical Packaging), IRBESARTAN (Lupin Pharmaceuticals), IRBESARTAN (Macleods Pharmaceuticals Limited), IRBESARTAN (Proficient Rx LP), IRBESARTAN (Qualitest Pharmaceuticals), IRBESARTAN (ScieGen Pharmaceuticals), IRBESARTAN (Solco Healthcare U.S.), IRBESARTAN (Solco healthcare U.S.), IRBESARTAN (Teva Pharmaceuticals USA), IRBESARTAN (Unichem Pharmaceuticals (USA)), IRBESARTAN (Unit Dose Services), IRBESARTAN (Watson Laboratories), IRBESARTAN (West-Ward Pharmaceuticals Corp.), IRBESARTAN (Westminster Pharmaceuticals)
Formula
C25H28N6O
Exact mass
428.2325
Mol weight
428.5294
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01495  Angiotensin II receptor antagonist
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antihypertensive [angiotensin II receptor antagonist]
Target
angiotensin II receptor type 1 (AT1) [HSA:185] [KO:K04166]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin-angiotensin system
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA04 Irbesartan
      D00523  Irbesartan (JP17/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Irbesartan
    D00523  Irbesartan (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00523  Irbesartan (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Irbesartan
      D00523  Irbesartan (JP17/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Irbesartan
    D00523  Irbesartan (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00523  Irbesartan
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00523
BRITE hierarchy
Other DBs
CAS: 
138402-11-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8x C     5.1800  -12.9500
            2   C8x C     5.1800  -14.3500
            3   C8x C     6.3924  -15.0500
            4   C8x C     7.6049  -14.3500
            5   C8y C     7.6049  -12.9500
            6   C8y C     6.3924  -12.2500
            7   C8y C     8.8360  -12.2390
            8   C8x C    10.0412  -12.9347
            9   C8x C    11.2535  -12.2346
            10  C8y C    11.2535  -10.8346
            11  C8x C    10.0483  -10.1389
            12  C8x C     8.8359  -10.8390
            13  C8y C     6.3924  -10.8502
            14  N5x N     7.5103  -10.0378
            15  N5x N     7.0831   -8.7236
            16  N5x N     5.7012   -8.7237
            17  N4x N     5.2743  -10.0381
            18  C1b C    12.4714  -10.1312
            19  N1y N    13.6834  -10.8307
            20  C5x C    13.6834  -12.2307
            21  C1z C    15.0148  -12.6634
            22  N2x N    15.8378  -11.5307
            23  C2y C    15.0148  -10.3981
            24  O5x O    12.5198  -13.0762
            25  C1b C    15.0148   -8.9981
            26  C1b C    16.1875   -8.3215
            27  C1b C    17.3902   -9.0164
            28  C1x C    14.1834  -13.7856
            29  C1x C    14.9992  -14.9234
            30  C1x C    16.3334  -14.4992
            31  C1x C    16.3422  -13.0992
            32  C1a C    18.5743   -8.3332
BOND        36
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    6  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   10  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 2
            26   19  23 1
            27   20  24 2
            28   23  25 1
            29   25  26 1
            30   26  27 1
            31   21  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   21  31 1
            36   27  32 1

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