KEGG   DRUG: PilocarpineHelp
Entry
D00525                      Drug                                   

Name
Pilocarpine (JAN/USP);
Ocusert pilo-20 (TN)
Formula
C11H16N2O2
Exact mass
208.1212
Mol weight
208.2569
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Source
Pilocarpus [TAX:77016]
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Cyp substrate
 DG01638  CYP2A6 substrate
Remark
Same as: C07474
ATC code: N07AX01 S01EB01
Chemical structure group: DG00992
Product (DG00992): D02200<JP/US>
Efficacy
Antiglaucoma, Muscarinic acetylcholine receptor agonist
Target
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04810  Regulation of actin cytoskeleton
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D00525  Pilocarpine (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D00525  Pilocarpine (JAN/USP)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D00525  Pilocarpine (JAN/USP)
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Pilocarpine
    D00525  Pilocarpine (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM2
     D00525  Pilocarpine (JAN/USP)
    CHRM3
     D00525  Pilocarpine (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 92-13-7
PubChem: 7847591
ChEBI: 8207
ChEMBL: CHEMBL550
DrugBank: DB01085
PDB-CCD: 9PL[PDBj]
LigandBox: D00525
NIKKAJI: J9.328I
KCF data Show

ATOM        15
            1   C1y C    24.1199  -19.7000
            2   C1y C    22.7112  -19.7000
            3   C1b C    25.3415  -20.3431
            4   C1x C    24.5641  -18.3555
            5   C7x C    22.2729  -18.3555
            6   C1b C    21.8810  -20.8399
            7   C8y C    26.4112  -19.7058
            8   O7x O    23.4185  -17.5255
            9   O6a O    20.9284  -17.9171
            10  C1a C    20.4782  -20.8338
            11  N4y N    27.8257  -19.7058
            12  C8x C    25.9670  -18.3614
            13  C8x C    28.2584  -18.3614
            14  C1a C    28.6499  -20.8456
            15  N5x N    27.1186  -17.5313
BOND        16
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2

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