KEGG   DRUG: D00531Help
Entry
D00531                      Drug                                   

Name
Nitrazepam (JP16/USAN/INN);
Benzalin (TN);
Nitrazepam (TN)
Formula
C15H11N3O3
Exact mass
281.08
Mol weight
281.2661
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant;
Sedative-hypnotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
Hypnotics
Anticonvulsants
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00531  Nitrazepam (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD02 Nitrazepam
      D00531  Nitrazepam (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Nitrazepam [ATC:N05CD02]
      D00531  Nitrazepam (JP16/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
146-22-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C2y C    12.1312   -8.7786
            2   C8y C    11.2876   -7.6671
            3   C8y C    11.6234   -6.3079
            4   N1x N    12.8866   -5.7287
            5   N2x N    13.5395   -8.7339
            6   C5x C    14.1424   -6.3521
            7   C1x C    14.4294   -7.7233
            8   C8x C    10.6145   -5.3378
            9   C8x C     9.2701   -5.7265
            10  C8y C     8.9343   -7.0857
            11  C8x C     9.9432   -8.0556
            12  O5x O    15.1884   -5.4161
            13  N2b N     7.5671   -7.4808 #+
            14  C8y C    11.4955  -10.0306
            15  C8x C    10.0915  -10.0306
            16  C8x C     9.3902  -11.2452
            17  C8x C    10.0915  -12.4597
            18  C8x C    11.4955  -12.4597
            19  C8x C    12.1968  -11.2452
            20  O3a O     7.5671   -8.8833
            21  O3a O     6.4666   -6.6538 #-
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   14  19 2
            22   13  20 2
            23   13  21 1

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