KEGG   DRUG: OxcarbazepineHelp
Entry
D00533                      Drug                                   

Name
Oxcarbazepine (JAN/USAN/INN);
Oxtellar (TN);
Trileptal (TN)
Product
  Generic
OXCARBAZEPINE (Aidarex Pharmaceuticals LLC), OXCARBAZEPINE (American Health Packaging), OXCARBAZEPINE (Amneal Pharmaceuticals), OXCARBAZEPINE (Breckenridge Pharmaceutical), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Bryant Ranch Prepack), OXCARBAZEPINE (Cardinal Health), TRILEPTAL (DIRECT RX), OXCARBAZEPINE (Glenmark Pharmaceuticals), OXCARBAZEPINE (Golden State Medical Supply), OXCARBAZEPINE (Golden State Medical Supply), OXCARBAZEPINE (Jubilant Cadista Pharmaceuticals), OXCARBAZEPINE (Medsource Pharmaceuticals), OXCARBAZEPINE (NCS HealthCare of KY), OXCARBAZEPINE (NCS HealthCare of KY), OXCARBAZEPINE (Physicians Total Care), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (REMEDYREPACK), OXCARBAZEPINE (Ranbaxy Pharmaceuticals), OXCARBAZEPINE (Rebel Distributors Corp), OXCARBAZEPINE (Sandoz), OXCARBAZEPINE (Sun Pharmaceutical Industries Limited), OXCARBAZEPINE (TYA Pharmaceuticals), OXCARBAZEPINE (TYA Pharmaceuticals), OXCARBAZEPINE (Taro Pharmaceuticals U.S.A.), OXCARBAZEPINE (West-Ward Pharmaceticals Corp.), OXCARBAZEPINE (West-Ward Pharmaceuticals Corp.)
Formula
C15H12N2O2
Exact mass
252.0899
Mol weight
252.268
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02034  Carboxamide antiepileptics
Cyp inhibitor
 DG01933  CYP2C19 inhibitor
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Remark
Same as: 
ATC code: 
Activity
Anticonvulsant, Antiepileptic
Comment
Carboxamide derivative
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841];
SCN10A [HSA:6336] [KO:K04842];
SCN11A [HSA:11280] [KO:K04843]
  Pathway
Dopaminergic synapse
Interaction
CYP induction: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Anticonvulsants
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF02 Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Oxcarbazepine
    D00533  Oxcarbazepine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN2A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN3A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN4A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN5A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN8A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN9A)
     Oxcarbazepine
      D00533  Oxcarbazepine (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Oxcarbazepine
    D00533  Oxcarbazepine (JAN/USAN/INN)
 CYP inducers
  CYP3A5
   Oxcarbazepine
    D00533  Oxcarbazepine (JAN/USAN/INN)
  CYP3A7
   Oxcarbazepine
    D00533  Oxcarbazepine (JAN/USAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00533
BRITE hierarchy
Other DBs
CAS: 
28721-07-5
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C5x C    18.8052  -13.4873
            2   C8y C    17.9608  -12.3747
            3   C8y C    18.2969  -11.0142
            4   N1y N    19.5614  -10.4345
            5   C1x C    20.2148  -13.5126
            6   C8y C    20.8183  -11.0585
            7   C8y C    21.1056  -12.4310
            8   C8x C    17.2870  -10.0431
            9   C8x C    15.9414  -10.4323
            10  C8x C    15.6053  -11.7928
            11  C8x C    16.6151  -12.7636
            12  C8x C    22.4404  -12.8693
            13  C8x C    23.4875  -11.9323
            14  C8x C    23.2004  -10.5598
            15  C8x C    21.8653  -10.1215
            16  C5a C    19.5131   -9.0558
            17  N1a N    20.7404   -8.3728
            18  O5x O    18.0836  -14.6869
            19  O5a O    18.2961   -8.3686
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20    1  18 2
            21   16  19 2

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