| Entry |
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| Name |
Zonisamide (JAN/USAN/INN);
Excegran (TN)
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| Product |
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| Generic |
ZONISAMIDE (American Health Packaging), ZONISAMIDE (American Health Packaging), ZONISAMIDE (Apotex Corp.), ZONISAMIDE (AvPAK), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Camber Pharmaceuticals), ZONISAMIDE (Dr. Reddy's Laboratories Limited), ZONISAMIDE (Eon Labs), ZONISAMIDE (Exelan Pharmaceuticals), ZONISAMIDE (Glenmark Generics), ZONISAMIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ZONISAMIDE (Mylan Institutional), ZONISAMIDE (Mylan Pharmaceuticals), ZONISAMIDE (NCS HealthCare of KY), ZONISAMIDE (Physicians Total Care), ZONISAMIDE (Rebel Distributors Corp), ZONISAMIDE (STAT RX USA LLC), ZONISAMIDE (STAT Rx USA LLC), ZONISAMIDE (Sun Pharmaceutical Industries Limited), ZONISAMIDE (WOCKHARDT LIMITED), ZONISAMIDE (WOCKHARDT USA LLC.) |
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| Formula |
C8H8N2O3S
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| Exact mass |
212.0256
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| Mol weight |
212.2257
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| Structure |
     |
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| Activity |
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
Benzisoxazole derivatives
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| Target |
voltage-gated sodium channel (SCN1A) blocker [HSA: 6323] [KO: K04833]; voltage-gated sodium channel (SCN2A) blocker [HSA: 6326] [KO: K04834]; voltage-gated sodium channel (SCN3A) blocker [HSA: 6328] [KO: K04836]; voltage-gated sodium channel (SCN4A) blocker [HSA: 6329] [KO: K04837]; voltage-gated sodium channel (SCN5A) blocker [HSA: 6331] [KO: K04838]; voltage-gated sodium channel (SCN8A) blocker [HSA: 6334] [KO: K04840]; voltage-gated sodium channel (SCN9A) blocker [HSA: 6335] [KO: K04841]; calcium channel T type blocker [HSA: 8911 8912 8913] [KO: K04856 K04855 K04854] |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| Anticonvulsants | | Sodium channel blocking drugs |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00538 Zonisamide (JAN/USAN/INN)
116 Antiparkinsonian agents
1169 Others
D00538 Zonisamide (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX15 Zonisamide
D00538 Zonisamide (JAN/USAN/INN)
USP drug classification [BR:br08302]
Anticonvulsants
Calcium Channel Modifying Agents
Zonisamide
D00538 Zonisamide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated cation channels
Na+ channel, SCN alpha, NaV1.x
voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
Ca2+ channel, CACN alpha-1, CaVx.x
calcium channel T type [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
Zonisamide [ATC:N03AX15]
D00538 Zonisamide (JAN/USAN/INN)
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| Other DBs |
CAS: 68291-97-4 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 14
1 C8y C 23.2246 -18.0420
2 C8y C 24.5519 -17.6112
3 C8y C 23.2246 -19.4447
4 C8x C 22.0139 -17.3435
5 N5x N 25.3783 -18.7462
6 O2x O 24.5576 -19.8813
7 C8x C 22.0139 -20.1433
8 C8x C 20.7973 -18.0420
9 C8x C 20.7973 -19.4447
10 C1b C 24.5519 -16.2112
11 S4a S 25.7651 -15.5107
12 O3c O 26.9775 -14.8107
13 N1a N 25.0763 -14.3183
14 O3c O 26.4767 -16.7426
BOND 15
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 3 7 1
7 4 8 2
8 7 9 2
9 5 6 1
10 8 9 1
11 2 10 1
12 10 11 1
13 11 12 2
14 11 13 1
15 11 14 2
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