KEGG   DRUG: D00538Help
Entry
D00538                      Drug                                   

Name
Zonisamide (JAN/USAN/INN);
Excegran (TN)
Product
  Generic
ZONISAMIDE (Aidarex Pharmaceuticals LLC), ZONISAMIDE (American Health Packaging), ZONISAMIDE (American Health Packaging), ZONISAMIDE (Apotex Corp.), ZONISAMIDE (AvPAK), ZONISAMIDE (BluePoint Laboratories), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Camber Pharmaceuticals), ZONISAMIDE (DIRECT RX), ZONISAMIDE (Dr. Reddy's Laboratories Limited), ZONISAMIDE (Eon Labs), ZONISAMIDE (Exelan Pharmaceuticals), ZONISAMIDE (Glenmark Generics), ZONISAMIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ZONISAMIDE (Mylan Institutional), ZONISAMIDE (Mylan Pharmaceuticals), ZONISAMIDE (NCS HealthCare of KY), ZONISAMIDE (Physicians Total Care), ZONISAMIDE (Rebel Distributors Corp), ZONISAMIDE (STAT RX USA LLC), ZONISAMIDE (STAT Rx USA LLC), ZONISAMIDE (Sun Pharmaceutical Industries Limited), ZONISAMIDE (WOCKHARDT LIMITED), ZONISAMIDE (WOCKHARDT USA LLC.)
Formula
C8H8N2O3S
Exact mass
212.0256
Mol weight
212.2257
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant [DS:H00807 H00808 H00809]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Benzisoxazole derivatives
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Anticonvulsants
Antiparkinsonian agents
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX15 Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Calcium Channel Modifying Agents
   Zonisamide
    D00538  Zonisamide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00538  Zonisamide (JAN/USAN/INN)
   116  Antiparkinsonian agents
    1169  Others
     D00538  Zonisamide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN2A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN3A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN4A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN5A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN8A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN9A)
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type
     Zonisamide
      D00538  Zonisamide (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Zonisamide
    D00538  Zonisamide (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
68291-97-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   C8y C    23.2246  -18.0420
            2   C8y C    24.5519  -17.6112
            3   C8y C    23.2246  -19.4447
            4   C8x C    22.0139  -17.3435
            5   N5x N    25.3783  -18.7462
            6   O2x O    24.5576  -19.8813
            7   C8x C    22.0139  -20.1433
            8   C8x C    20.7973  -18.0420
            9   C8x C    20.7973  -19.4447
            10  C1b C    24.5519  -16.2112
            11  S4a S    25.7651  -15.5107
            12  O3c O    26.9775  -14.8107
            13  N1a N    25.0763  -14.3183
            14  O3c O    26.4767  -16.7426
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     5   6 1
            10    8   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 2
            14   11  13 1
            15   11  14 2

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