KEGG   DRUG: EthosuximideHelp
Entry
D00539                      Drug                                   

Name
Ethosuximide (JP17/USP/INN);
Zarontin (TN)
Product
  Generic
Formula
C7H11NO2
Exact mass
141.079
Mol weight
141.1677
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02033  Succinimide antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Cyp substrate
 DG01633  CYP3A substrate
Remark
Same as: C07505
Therapeutic category: 1139
ATC code: N03AD01
Product: D00539<JP/US>
Efficacy
Antiepileptic
Comment
Succinimide derivative
Target
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
map07036  Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AD Succinimide derivatives
     N03AD01 Ethosuximide
      D00539  Ethosuximide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Calcium Channel Modifying Agents
   Ethosuximide
    D00539  Ethosuximide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00539  Ethosuximide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00539  Ethosuximide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00539  Ethosuximide
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00539
BRITE hierarchy
Other DBs
CAS: 77-67-8
PubChem: 7847605
ChEBI: 4887
ChEMBL: CHEMBL696
DrugBank: DB00593
LigandBox: D00539
NIKKAJI: J1.477J
KCF data Show

ATOM        10
            1   C1z C    30.2572  -15.7833
            2   C5x C    31.0718  -14.6371
            3   C1x C    28.9189  -15.3703
            4   C1b C    31.5607  -16.2779
            5   C1a C    29.4311  -16.9121
            6   N1x N    30.2341  -13.5199
            7   O5x O    32.4683  -14.6255
            8   C5x C    28.9016  -13.9681
            9   C1a C    31.5774  -17.6569
            10  O5x O    27.7611  -13.1534
BOND        10
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     4   9 1
            9     8  10 2
            10    6   8 1

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