KEGG   DRUG: D00540Help
Entry
D00540                      Drug                                   
Name
Glycopyrronium bromide (JAN/INN);
Glycopyrrolate (USP);
Robinul (TN);
Seebri breezhaler (TN)
Product
  Generic
Formula
C19H28NO3. Br
Exact mass
397.1253
Mol weight
398.3345
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic
Remark
Therapeutic category: 
ATC code: 
Target
muscarinic cholinergic receptor M3 antagonist [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D00540  Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    A03AB Synthetic anticholinergics, quaternary ammonium compounds
     A03AB02 Glycopyrronium
      D00540  Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP)
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BB Anticholinergics
     R03BB06 Glycopyrronium bromide
      D00540  Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Glycopyrrolate
    D00540  Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
     Glycopyrronium [ATC:A03AB02]
      D00540  Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP)
BRITE hierarchy
Other DBs
CAS: 
596-51-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C1d C    24.1031  -22.1674
            2   C7a C    22.9701  -22.8047
            3   O7a O    21.7662  -22.1674
            4   O6a O    22.9701  -24.2210
            5   C1y C    20.4915  -22.8756
            6   C1x C    19.4128  -22.0966
            7   C1x C    20.0908  -24.2414
            8   N2y N    18.2555  -22.8879 #+
            9   C1x C    18.7293  -24.2018
            10  C1y C    25.3216  -22.8892
            11  C1x C    25.7607  -24.2172
            12  C1x C    27.1619  -24.2138
            13  C1x C    27.5915  -22.8800
            14  C1x C    26.4559  -22.0593
            15  C8y C    24.1031  -20.7511
            16  C8x C    25.3296  -20.0429
            17  C8x C    25.3296  -18.6266
            18  C8x C    24.1031  -17.9184
            19  C8x C    22.8766  -18.6266
            20  C8x C    22.8766  -20.0429
            21  O1a O    25.1880  -21.3176
            22  C1a C    17.0289  -22.1798
            23  C1a C    17.0289  -23.5960
            24  X   Br   17.5880  -25.3541 #-
BOND        25
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     3   5 1
            5     5   6 1
            6     5   7 1
            7     6   8 1
            8     7   9 1
            9     8   9 1
            10    1  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23    1  21 1
            24    8  22 1
            25    8  23 1

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