KEGG   DRUG: D00550Help
Entry
D00550                      Drug                                   

Name
Midazolam (JAN/USP/INN);
Dormicum (TN);
Buccolam (TN)
Formula
C18H13ClFN3
Exact mass
325.0782
Mol weight
325.7673
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP4B1 [HSA:1580]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D00550  Midazolam (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00550  Midazolam (JAN/USP/INN)
   113  Antiepileptics
    1139  Others
     D00550  Midazolam (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Midazolam
      D00550  Midazolam (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Midazolam
    D00550  Midazolam (JAN/USP/INN)
  CYP3A5
   Midazolam
    D00550  Midazolam (JAN/USP/INN)
  CYP3A7
   Midazolam
    D00550  Midazolam (JAN/USP/INN)
  CYP4B1
   Midazolam
    D00550  Midazolam (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
59467-70-8
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C2y C    16.5834  -17.0194
            2   C8y C    15.7413  -15.9098
            3   C8y C    16.0765  -14.5530
            4   N4y N    17.3375  -13.9749
            5   N2x N    17.9892  -17.0446
            6   C8y C    18.5911  -14.5972
            7   C1x C    18.8776  -15.9659
            8   C8x C    15.0694  -13.5846
            9   C8x C    13.7274  -13.9727
            10  C8y C    13.3922  -15.3295
            11  C8x C    14.3993  -16.2976
            12  X   Cl   12.0274  -15.7239
            13  C8y C    15.9489  -18.2691
            14  C8x C    14.5473  -18.2691
            15  C8x C    13.8473  -19.4816
            16  C8x C    14.5473  -20.6940
            17  C8x C    15.9489  -20.6940
            18  C8y C    16.6489  -19.4816
            19  X   F    18.0598  -19.4817
            20  C8x C    19.5704  -13.5973
            21  N5x N    18.9220  -12.3570
            22  C8y C    17.5420  -12.5904
            23  C1a C    16.5611  -11.6294
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21   18  19 1
            22    6  20 2
            23   20  21 1
            24   21  22 2
            25    4  22 1
            26   22  23 1

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