KEGG   DRUG: D00551Help
Entry
D00551                      Drug                                   

Name
Tetracaine (USP/INN);
Amethocaine;
Amethocaine (TN)
Formula
C15H24N2O2
Exact mass
264.1838
Mol weight
264.3633
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [topical]
Remark
Same as: 
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842]
Interaction
Drug interaction
Structure map
Local analgesics
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD02 Tetracaine
      D00551  Tetracaine (USP/INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB06 Tetracaine
      D00551  Tetracaine (USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA03 Tetracaine
      D00551  Tetracaine (USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA03 Tetracaine
      D00551  Tetracaine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN2A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN3A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN4A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN5A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN8A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN9A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
    voltage-gated sodium channel (SCN10A)
     Tetracaine
      D00551  Tetracaine (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
94-24-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    25.5212  -17.9670
            2   C7a C    26.7355  -18.6618
            3   C8x C    25.5212  -16.5600
            4   C8x C    24.3067  -18.6677
            5   O7a O    27.9499  -17.9670
            6   O6a O    26.7355  -20.0689
            7   C8x C    24.3067  -15.8535
            8   C8x C    23.0981  -17.9728
            9   C1b C    29.1642  -18.6560
            10  C8y C    23.0923  -16.5600
            11  C1b C    30.3785  -17.9611
            12  N1b N    21.8721  -15.8594
            13  N1c N    31.5930  -18.6501
            14  C1b C    20.6695  -16.5600
            15  C1a C    32.7956  -17.9494
            16  C1a C    31.5930  -20.0513
            17  C1b C    19.4610  -15.8594
            18  C1b C    18.2524  -16.5600
            19  C1a C    17.0497  -15.8594
BOND        19
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   17  18 1
            18   18  19 1
            19    8  10 2

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