KEGG   DRUG: D00552Help
Entry
D00552                      Drug                                   

Name
Ethyl aminobenzoate (JP16);
Benzocaine (USP/INN);
Parathesin (TN)
Product
  Other
DENTI-CARE DENTI-FREEZE (AR Medicom), DENTI-CARE DENTI-FREEZE (AR Medicom), DENTI-CARE DENTI-FREEZE (AR Medicom), DENTI-CARE DENTI-FREEZE (AR Medicom), DENTI-CARE DENTI-FREEZE (AR Medicom), BEEGENTLE (CAO Group), BENZOCAINE (Centrix), TOPEX (DENTSPLY Caulk), TOPEX (DSHealthcare), SUPERDENT (Darby Dental Supply LLC), OPAHL (Dharma Research), BENZO-JEL (Henry Schein), BENZO-JEL (Henry Schein), PENNACAINE (Larken Laboratories), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), GELATO TOPICAL ANESTHETIC (Mycone Dental Supply), TOPICAL ANESTHETIC (Patterson Dental)
Formula
C9H11NO2
Exact mass
165.079
Mol weight
165.1891
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [topical]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Local analgesics
Benzoic acid family
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1212  Aminobenzoate alkyl esters
     D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
  27  Dental preparations
   271  Local anesthetics
    2710  Local anesthetics
     D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD03 Benzocaine
      D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB04 Benzocaine
      D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA05 Benzocaine
      D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD01 Benzocaine
      D00552  Ethyl aminobenzoate (JP16); Benzocaine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
     Benzocaine [ATC:C05AD03 D02BA01 D04AB04 N01BA05 R02AD01]
      D00552  Benzocaine (USP/INN)
     Aminobenzoic acid [ATC:D02BA01]
      D00552  Benzocaine (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
94-09-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8y C    20.6329  -17.3424
            2   C7a C    21.8450  -18.0357
            3   C8x C    20.6329  -15.9380
            4   C8x C    19.4209  -18.0416
            5   O7a O    23.0569  -17.3424
            6   O6a O    21.8450  -19.4401
            7   C8x C    19.4209  -15.2330
            8   C8x C    18.2148  -17.3481
            9   C1b C    24.2688  -18.0299
            10  C8y C    18.2089  -15.9380
            11  C1a C    25.4808  -17.3365
            12  N1a N    16.9911  -15.2388
BOND        12
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12    8  10 2

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