KEGG   DRUG: BenzocaineHelp
Entry
D00552                      Drug                                   

Name
Benzocaine (USP/INN);
Ethyl aminobenzoate (JP17);
Parathesin (TN)
Product
  Other
Formula
C9H11NO2
Exact mass
165.079
Mol weight
165.1891
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01674  Esterified local anesthetic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anesthetic (topical), Analgesic, Antipruritic
Target
voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
Interaction
Drug interaction
Structure map
Local analgesics
Benzoic acid family
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD03 Benzocaine
      D00552  Benzocaine (USP/INN)
 D DERMATOLOGICALS
  D02 EMOLLIENTS AND PROTECTIVES
   D02B PROTECTIVES AGAINST UV-RADIATION
    D02BA Protectives against UV-radiation for topical use
     D02BA01 Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB04 Benzocaine
      D00552  Benzocaine (USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA05 Benzocaine
      D00552  Benzocaine (USP/INN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD01 Benzocaine
      D00552  Benzocaine (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1212  Aminobenzoate alkyl esters
     D00552  Benzocaine (USP/INN); Ethyl aminobenzoate (JP17)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00552  Benzocaine (USP/INN); Ethyl aminobenzoate (JP17)
  27  Dental preparations
   271  Local anesthetics
    2710  Local anesthetics
     D00552  Benzocaine (USP/INN); Ethyl aminobenzoate (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D00552  Benzocaine (USP/INN)
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00552  Benzocaine (USP/INN)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00552  Benzocaine (USP/INN)
 Agents for otolaryngologic use
  72 Other agents for otolaryngologic use
   D00552  Benzocaine (USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Ethyl aminobenzoate
    D00552  Benzocaine (USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ethyl aminobenzoate
    D00552  Benzocaine (USP/INN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Ethyl aminobenzoate
    D00552  Benzocaine (USP/INN)
Pharmaceutical additives [BR:br08316]
 Soothing agent
  D00552  [001027] Ethyl aminobenzoate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN2A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN3A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN4A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN5A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN8A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN9A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
    voltage-gated sodium channel (SCN10A)
     Aminobenzoic acid
      D00552  Benzocaine (USP/INN)
     Benzocaine
      D00552  Benzocaine (USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00552  Ethyl aminobenzoate
Anesthetics and analgesics [br08369.html]
 Anesthetics
  D00552
BRITE hierarchy
Other DBs
CAS: 
94-09-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8y C    20.6329  -17.3424
            2   C7a C    21.8450  -18.0357
            3   C8x C    20.6329  -15.9380
            4   C8x C    19.4209  -18.0416
            5   O7a O    23.0569  -17.3424
            6   O6a O    21.8450  -19.4401
            7   C8x C    19.4209  -15.2330
            8   C8x C    18.2148  -17.3481
            9   C1b C    24.2688  -18.0299
            10  C8y C    18.2089  -15.9380
            11  C1a C    25.4808  -17.3365
            12  N1a N    16.9911  -15.2388
BOND        12
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12    8  10 2

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