KEGG   DRUG: D00558Help
Entry
D00558                      Drug                                   

Name
Carbidopa hydrate (JP16);
Carbidopa (USP);
Lodosyn (TN)
Product
  Generic
Formula
C10H14N2O4. H2O
Exact mass
244.1059
Mol weight
244.2444
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibitor [decarboxylase]
Comment
Peripheral aromatic L-amino acid decarboxylase inhibitors (DCI)
Target
aromatic-L-amino-acid decarboxylase inhibitor [HSA:1644] [KO:K01593]
  Pathway
hsa00340  Histidine metabolism
hsa00350  Tyrosine metabolism
hsa00360  Phenylalanine metabolism
hsa00380  Tryptophan metabolism
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Brite
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Precursors/L-Amino Acid Decarboxylase Inhibitors
   Carbidopa
    D00558  Carbidopa hydrate (JP16); Carbidopa (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases
   aromatic-L-amino-acid decarboxylase
    Carbidopa
     D00558  Carbidopa (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00558  Carbidopa hydrate
BRITE hierarchy
Other DBs
CAS: 
38821-49-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   O0  O    24.5218  -16.1191
            2   C8y C    14.0190  -16.1917
            3   C8y C    14.0190  -17.5936
            4   C8x C    15.2106  -18.2946
            5   C8x C    16.4723  -17.5936
            6   C8y C    16.4723  -16.1917
            7   C8x C    15.2106  -15.4907
            8   O1a O    12.8273  -15.4907
            9   O1a O    12.8273  -18.2946
            10  C1b C    17.6640  -15.4907
            11  C1d C    18.8556  -16.1917
            12  C6a C    20.0473  -15.4907
            13  O6a O    21.2389  -16.1917
            14  O6a O    20.0473  -14.0888
            15  N1b N    19.5556  -17.4041
            16  C1a C    17.8657  -17.1816
            17  N1a N    20.9298  -17.4046
BOND        16
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     3   9 1
            9     6  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 2
            14   11  15 1 #Up
            15   11  16 1 #Down
            16   15  17 1

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