| Entry |
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| Name |
Pimozide (JP16/USP/INN);
Orap (TN)
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| Product |
|
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| Formula |
C28H29F2N3O
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| Exact mass |
461.2279
|
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| Mol weight |
461.5462
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| Structure |
     |
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| Activity |
Antipsychotic
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
Butyrophenone derivatives
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| Target |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565]
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| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
CYP inhibition: CYP2D6 [HSA: 1565]
 |
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| Structure map |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00560 Pimozide (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AG Diphenylbutylpiperidine derivatives
N05AG02 Pimozide
D00560 Pimozide (JP16/USP/INN)
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Pimozide
D00560 Pimozide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
Pimozide [ATC:N05AG02]
D00560 Pimozide (JP16/USP/INN)
Dopamine
dopamine D2-receptor [HSA:1813] [KO:K04145]
Pimozide [ATC:N05AG02]
D00560 Pimozide (JP16/USP/INN)
dopamine D3-receptor [HSA:1814] [KO:K04146]
Pimozide [ATC:N05AG02]
D00560 Pimozide (JP16/USP/INN)
 |
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| Other DBs |
CAS: 2062-78-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 34
1 C8x C 3.3600 -23.5200
2 C8y C 3.3600 -24.9200
3 C8x C 4.5724 -25.6200
4 C8x C 5.7849 -24.9200
5 C8y C 5.7849 -23.5200
6 C8x C 4.5724 -22.8200
7 C8x C 8.2097 -24.9200
8 C8y C 8.2097 -23.5200
9 C1c C 6.9973 -22.8200
10 C8x C 9.4222 -25.6200
11 C8y C 10.6346 -24.9200
12 C8x C 10.6346 -23.5200
13 C8x C 9.4222 -22.8200
14 X F 2.1476 -25.6200
15 X F 11.8511 -25.6223
16 C1b C 6.9973 -21.4200
17 C1b C 8.2118 -20.7188
18 C1b C 9.4083 -21.4098
19 N1y N 10.5951 -20.7246
20 C1x C 11.7866 -21.4128
21 C1x C 12.9991 -20.7129
22 C1y C 12.9993 -19.3129
23 C1x C 11.8078 -18.6248
24 C1x C 10.5953 -19.3246
25 N4y N 14.2241 -18.6058
26 C8y C 14.2241 -17.2058
27 O5x O 13.0074 -16.5032
28 C8y C 15.5556 -19.0384
29 C8y C 16.3785 -17.9058
30 N4x N 15.5556 -16.7732
31 C8x C 17.7785 -17.9058
32 C8x C 18.4851 -19.1295
33 C8x C 17.7922 -20.3294
34 C8x C 16.3803 -20.3296
BOND 38
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 2 14 1
16 11 15 1
17 9 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 21 22 1
24 22 23 1
25 23 24 1
26 19 24 1
27 22 25 1
28 25 26 1
29 26 27 2
30 25 28 1
31 28 29 2
32 29 30 1
33 26 30 1
34 29 31 1
35 31 32 2
36 32 33 1
37 33 34 2
38 34 28 1
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