KEGG   DRUG: D00561Help
Entry
D00561                      Drug                                   

Name
Sertindole (USAN/INN);
SerLect (TN)
Formula
C24H26ClFN4O
Exact mass
440.1779
Mol weight
440.9408
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic;
Neuroleptic
Remark
Same as: 
ATC code: 
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Antipsychotics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AE Indole derivatives
     N05AE03 Sertindole
      D00561  Sertindole (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Sertindole
      D00561  Sertindole (USAN/INN)
   Dopamine
    dopamine D2-receptor
     Sertindole
      D00561  Sertindole (USAN/INN)
   Serotonin
    5-HT2A-receptor
     Sertindole
      D00561  Sertindole (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
106516-24-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C8y C     6.0200  -19.6000
            2   C8x C     6.0200  -21.0000
            3   C8x C     7.2324  -21.7000
            4   C8y C     8.4449  -21.0000
            5   C8y C     8.4449  -19.6000
            6   C8x C     7.2324  -18.9000
            7   N4y N     9.6573  -21.7000
            8   C8x C    10.8698  -21.0000
            9   C8y C    10.8698  -19.6000
            10  C8y C     9.6573  -23.1000
            11  C8x C     8.4469  -23.7988
            12  C8x C     8.4469  -25.1988
            13  C8y C     9.6593  -25.8988
            14  C8x C    10.8698  -25.2000
            15  C8x C    10.8698  -23.8000
            16  X   Cl    4.8076  -18.9000
            17  X   F     9.6593  -27.3000
            18  C1y C    12.0822  -18.9000
            19  C1x C    13.3153  -19.6122
            20  C1x C    14.5279  -18.9124
            21  N1y N    14.5281  -17.5124
            22  C1x C    13.2950  -16.8002
            23  C1x C    12.0824  -17.5000
            24  C1b C    15.7699  -16.7956
            25  C1b C    16.9691  -17.4883
            26  N1y N    18.1547  -16.8040
            27  C5x C    19.2982  -17.6133
            28  N1x N    20.4193  -16.7747
            29  C1x C    19.9682  -15.4494
            30  C1x C    18.5683  -15.4688
            31  O5x O    19.3165  -19.0400
BOND        35
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    7  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    1  16 1
            19   13  17 1
            20    9  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   18  23 1
            27   21  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   26  30 1
            35   27  31 2

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