KEGG   DRUG: D00562Help
Entry
D00562                      Drug                                   

Name
Propylthiouracil (JP16/USP/INN);
Propylthiouracil (TN)
Product
  Generic
Formula
C7H10N2OS
Exact mass
170.0514
Mol weight
170.2321
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Thyroid inhibitor [DS:H00082]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Indication: Graves' disease
Target
thyroid peroxidase inhibitor [HSA:7173] [KO:K00431];
deiodinase, iodothyronine, type I inhibitor [HSA:1733] [KO:K01562];
deiodinase, iodothyronine, type II inhibitor [HSA:1734] [KO:K17904]
  Pathway
hsa00350  Tyrosine metabolism
hsa05320  Autoimmune thyroid disease  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BA Thiouracils
     H03BA02 Propylthiouracil
      D00562  Propylthiouracil (JP16/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Thyroid)
  Antithyroid Agents
   Propylthiouracil
    D00562  Propylthiouracil (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2432  Antithyroid hormones
     D00562  Propylthiouracil (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   thyroid peroxidase
    Propylthiouracil
     D00562  Propylthiouracil (JP16/USP/INN)
   type I iodothyronine deiodinase
    Propylthiouracil
     D00562  Propylthiouracil (JP16/USP/INN)
   type II iodothyronine deiodinase
    Propylthiouracil
     D00562  Propylthiouracil (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00562  Propylthiouracil
  D00562  Propylthiouracil tablets
BRITE hierarchy
Other DBs
CAS: 
51-52-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        11
            1   C8y C    25.3173  -19.8324
            2   C8x C    25.3173  -18.4289
            3   N4x N    26.5346  -20.5256
            4   C1b C    24.1060  -20.5256
            5   C8y C    26.5346  -17.7243
            6   C8y C    27.7461  -19.8324
            7   C1b C    22.8887  -19.8324
            8   N4x N    27.7461  -18.4289
            9   O5x O    26.5346  -16.3265
            10  S0  S    28.9574  -20.5256
            11  C1a C    21.6774  -20.5313
BOND        11
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    6   8 1

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