KEGG   DRUG: MirtazapineHelp
Entry
D00563                      Drug                                   

Name
Mirtazapine (JAN/USAN/INN);
Remeron (TN);
Reflex (TN)
Product
  Generic
MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (Actavis Pharma), MIRTAZAPINE (Actavis Pharma), MIRTAZAPINE (Aidarex Pharmaceuticals LLC), MIRTAZAPINE (Aidarex Pharmaceuticals LLC), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Apotex Corp.), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurolife Pharma LLC), MIRTAZAPINE (Avera McKennan Hospital), MIRTAZAPINE (Avera McKennan Hospital), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Citron Pharma LLC), MIRTAZAPINE (Citron Pharma LLC), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Contract Pharmacy Services-PA), MIRTAZAPINE (DIRECT RX), MIRTAZAPINE (Direct Rx), MIRTAZAPINE (DirectRX), MIRTAZAPINE (Eon Labs), MIRTAZAPINE (H.J. Harkins Company), MIRTAZAPINE (KAISER FOUNDATION HOSPITALS), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical Medical DBA Quality Care Products LLC), MIRTAZAPINE (Major Pharmaceuticals), MIRTAZAPINE (McKesson Contract Packaging), MIRTAZAPINE (McKesson Packaging Services Business Unit of McKesson Corporation), MIRTAZAPINE (Medsource Pharmaceuticals), MIRTAZAPINE (Mylan Institutional), MIRTAZAPINE (Mylan Pharmaceuticals), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (PD-Rx Pharmaceuticals), MIRTAZAPINE (PD-Rx Pharmaceuticals), MIRTAZAPINE (Physicians Total Care), MIRTAZAPINE (Physicians Total Care), MIRTAZAPINE (Prasco Laboratories), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (Rebel Distributors Corp), MIRTAZAPINE (Rebel Distributors Corp), MIRTAZAPINE (Rebel Distributors Corp.), MIRTAZAPINE (STAT Rx USA LLC), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (Sun Pharmaceutical Industries), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (Teva Pharmaceuticals USA), MIRTAZAPINE (Teva Pharmaceuticals USA), MIRTAZAPINE (Unit Dose Services)
Formula
C17H19N3
Exact mass
265.1579
Mol weight
265.3529
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01729  Tetracyclic antidepressant
Other
 DG01489  5-HT3-receptor antagonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antidepressant, NaSSA
Comment
NaSSA: Noradrenergic and specific serotonergic antidepressant
Target
5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157];
5-HT3-receptor [HSA:3359 9177 170572 200909 285242] [KO:K04819];
alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX11 Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00563  Mirtazapine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha2-adrenergic receptor
     Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
   Serotonin
    5-HT2-receptor
     Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
    5-HT3-receptor
     Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
  CYP2D6
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
  CYP3A4
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
Psychiatric agents [br08363.html]
 Antidepressants
  D00563
BRITE hierarchy
Other DBs
CAS: 
85650-52-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1y C     9.7476   -8.2180
            2   N1y N    11.1496   -8.2180
            3   C8y C    11.9909   -7.1665
            4   C8y C    11.7105   -5.7644
            5   C8y C     8.9064   -7.1665
            6   C1x C    10.4486   -5.2036
            7   C8y C     9.1868   -5.7644
            8   C8x C     7.5744   -7.5871
            9   C8x C     6.5229   -6.6056
            10  C8x C     6.8033   -5.2737
            11  C8x C     8.1353   -4.8531
            12  C8x C    12.6919   -4.8531
            13  C8x C    14.0238   -5.2737
            14  C8x C    14.3743   -6.6056
            15  N5x N    13.3228   -7.5170
            16  C1x C    11.8507   -9.4097
            17  C1x C    11.1496  -10.6715
            18  N1y N     9.8177  -10.6715
            19  C1x C     9.0466   -9.4798
            20  C1a C     9.1167  -11.9334
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 2
            6     1   2 1
            7     6   7 1
            8     5   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12    7  11 1
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    3  15 2
            18    2  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    1  19 1
            23   18  20 1

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