KEGG   DRUG: D00563Help
Entry
D00563                      Drug                                   

Name
Mirtazapine (JAN/USAN/INN);
Remeron (TN);
Reflex (TN)
Product
  Generic
MIRTAZAPINE (Actavis Pharma), MIRTAZAPINE (Actavis Pharma), MIRTAZAPINE (Aidarex Pharmaceuticals LLC), MIRTAZAPINE (Aidarex Pharmaceuticals LLC), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Apotex Corp.), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurolife Pharma LLC), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Cardinal Health), MIRTAZAPINE (Citron Pharma LLC), MIRTAZAPINE (Citron Pharma LLC), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Clinical Solutions Wholesale), MIRTAZAPINE (Contract Pharmacy Services-PA), MIRTAZAPINE (Eon Labs), MIRTAZAPINE (Greenstone LLC), MIRTAZAPINE (Greenstone LLC), MIRTAZAPINE (H.J. Harkins Company), MIRTAZAPINE (KAISER FOUNDATION HOSPITALS), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (Lake Erie Medical DBA Quality Care Products LLC), MIRTAZAPINE (McKesson Contract Packaging), MIRTAZAPINE (McKesson Packaging Services Business Unit of McKesson Corporation), MIRTAZAPINE (Mylan Institutional), MIRTAZAPINE (Mylan Pharmaceuticals), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (PD-Rx Pharmaceuticals), MIRTAZAPINE (Physicians Total Care), MIRTAZAPINE (Physicians Total Care), MIRTAZAPINE (Prasco Laboratories), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (Rebel Distributors Corp), MIRTAZAPINE (Rebel Distributors Corp), MIRTAZAPINE (Rebel Distributors Corp.), MIRTAZAPINE (STAT Rx USA LLC), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (State of Florida DOH Central Pharmacy), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (TYA Pharmaceuticals), MIRTAZAPINE (Teva Pharmaceuticals USA), MIRTAZAPINE (Teva Pharmaceuticals USA), MIRTAZAPINE (Unit Dose Services), MIRTAZAPINE (Watson Laboratories)
Formula
C17H19N3
Exact mass
265.1579
Mol weight
265.3529
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX11 Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00563  Mirtazapine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha2-adrenergic receptor
     Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
   Serotonin
    5-HT2-receptor
     Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
    5-HT3-receptor
     Mirtazapine
      D00563  Mirtazapine (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
  CYP2D6
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
  CYP3A4
   Mirtazapine
    D00563  Mirtazapine (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
85650-52-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1y C     9.7476   -8.2180
            2   N1y N    11.1496   -8.2180
            3   C8y C    11.9909   -7.1665
            4   C8y C    11.7105   -5.7644
            5   C8y C     8.9064   -7.1665
            6   C1x C    10.4486   -5.2036
            7   C8y C     9.1868   -5.7644
            8   C8x C     7.5744   -7.5871
            9   C8x C     6.5229   -6.6056
            10  C8x C     6.8033   -5.2737
            11  C8x C     8.1353   -4.8531
            12  C8x C    12.6919   -4.8531
            13  C8x C    14.0238   -5.2737
            14  C8x C    14.3743   -6.6056
            15  N5x N    13.3228   -7.5170
            16  C1x C    11.8507   -9.4097
            17  C1x C    11.1496  -10.6715
            18  N1y N     9.8177  -10.6715
            19  C1x C     9.0466   -9.4798
            20  C1a C     9.1167  -11.9334
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 2
            6     1   2 1
            7     6   7 1
            8     5   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12    7  11 1
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    3  15 2
            18    2  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    1  19 1
            23   18  20 1

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