KEGG   DRUG: D00564Help
Entry
D00564                      Drug                                   

Name
Warfarin sodium (USP);
Coumadin (TN);
Jantoven (TN)
Product
  Generic
WARFARIN SODIUM (Aidarex Pharmaceuticals LLC), WARFARIN SODIUM (Amneal Pharmaceuticals), WARFARIN SODIUM (Aidarex Pharmaceuticals LLC), WARFARIN SODIUM (Aidarex Pharmaceuticals LLC), WARFARIN SODIUM (American Health Packaging), WARFARIN SODIUM (American Health Packaging), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Barr Laboratories), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Cadila Healthcare Limited), WARFARIN SODIUM (Camber Pharmaceuticals), WARFARIN SODIUM (Cardinal Health), JANTOVEN (Cardinal Health), WARFARIN SODIUM (Clinical Solutions Wholesale), WARFARIN SODIUM (Clinical Solutions Wholesale), WARFARIN SODIUM (Golden State Medical Supply), WARFARIN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), WARFARIN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), WARFARIN SODIUM (Med-Health Pharma), WARFARIN SODIUM (New Horizon Rx Group), WARFARIN SODIUM (PD-Rx Pharmaceuticals), WARFARIN SODIUM (PD-Rx Pharmaceuticals), WARFARIN SODIUM (PD-Rx Pharmaceuticals), WARFARIN SODIUM (PD-Rx Pharmaceuticals), WARFARIN SODIUM (Physicians Total Care), WARFARIN SODIUM (Physicians Total Care), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), JANTOVEN (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (ReadyMeds), WARFARIN SODIUM (Rebel Distributors Corp), WARFARIN SODIUM (STAT Rx USA LLC), WARFARIN SODIUM (STAT Rx USA LLC), WARFARIN SODIUM (St Marys Medical Park Pharmacy), WARFARIN SODIUM (St Marys Medical Park Pharmacy), WARFARIN SODIUM (State of Florida DOH Central Pharmacy), WARFARIN SODIUM (TYA Pharmaceuticals), WARFARIN SODIUM (TYA Pharmaceuticals), WARFARIN SODIUM (Taro Pharmaceuticals U.S.A.), WARFARIN SODIUM (Unit Dose Services), WARFARIN SODIUM (Unit Dose Services), WARFARIN SODIUM (Unit Dose Services), WARFARIN SODIUM (Unit Dose Services), WARFARIN SODIUM (Unit Dose Services), WARFARIN SODIUM (Unit Dose Services), JANTOVEN (Upsher-Smith Laboratories), WARFARIN SODIUM (Zydus Pharmaceuticals (USA))
Formula
C19H15O4. Na
Exact mass
330.0868
Mol weight
330.3098
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticoagulant, vitamin K antagonist
Remark
ATC code: 
Drug group: 
Comment
coumarin derivative
Target
vitamin-K-epoxide reductase inhibitor [HSA:79001] [KO:K05357];
phylloquinone reductase inhibitor [HSA:1728] [KO:K00355]
  Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP1A2 [HSA:1544]
Interaction
Genomic biomarker: VKORC1 [HSA:79001], CYP2C9 [HSA:1559]
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AA Vitamin K antagonists
     B01AA03 Warfarin
      D00564  Warfarin sodium (USP)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Anticoagulants
   Warfarin
    D00564  Warfarin sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   vitamin-K-epoxide reductase
    Warfarin
     D00564  Warfarin sodium (USP)
   phylloquinone reductase
    Warfarin
     D00564  Warfarin sodium (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Warfarin
    D00564  Warfarin sodium (USP)
  CYP2C9
   Warfarin
    D00564  Warfarin sodium (USP)
Phytochemicals used as drugs [BR:br08306]
 Phenylpropanoids and related compounds
  Coumarins
   D00564  Warfarin sodium (USP)
BRITE hierarchy
Other DBs
CAS: 
129-06-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    24.8370  -17.3313
            2   C1c C    26.0487  -18.0418
            3   C8y C    23.6253  -18.0245
            4   C8y C    24.8428  -15.9389
            5   C1b C    27.2662  -17.3429
            6   C8y C    22.4252  -17.3137
            7   O1a O    23.6894  -19.4226 #-
            8   O7x O    23.6427  -15.2398
            9   O6a O    26.0661  -15.2515
            10  C5a C    28.4721  -18.0534
            11  C8y C    22.4311  -15.9215
            12  C8x C    21.2135  -18.0245
            13  C1a C    28.4662  -19.4576
            14  O5a O    29.6837  -17.3604
            15  C8x C    21.2193  -15.2224
            16  C8x C    20.0077  -17.3196
            17  C8x C    20.0077  -15.9156
            18  C8y C    26.0423  -19.4449
            19  C8x C    24.8108  -20.1486
            20  C8x C    24.8046  -21.5475
            21  C8x C    26.0129  -22.2524
            22  C8x C    27.2445  -21.5486
            23  C8x C    27.2507  -20.1497
            24  Z   Na   21.3600  -19.4568 #+
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 2
            14   11  15 1
            15   12  16 2
            16   15  17 2
            17    8  11 1
            18   16  17 1
            19    2  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1

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