KEGG   DRUG: FenofibrateHelp
Entry
D00565                      Drug                                   

Name
Fenofibrate (JAN/INN);
Antara (TN);
Lipantil (TN);
Lipofen (TN);
Tricor (TN);
Triglide (TN)
Product
  Generic
FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (ANI Pharmaceuticals), FENOFIBRATE (Aidarex Pharmaceuticals LLC), FENOFIBRATE (American Health Packaging), FENOFIBRATE (American Health Packaging), FENOFIBRATE (American Health Packaging), FENOFIBRATE (Aphena Pharma Solutions - Tennessee), FENOFIBRATE (Apotex Corp.), FENOFIBRATE (Aurobindo Pharma Limited), FENOFIBRATE (AvKARE), FENOFIBRATE (AvKARE), FENOFIBRATE (AvPAK), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Camber Pharmaceuticals), FENOFIBRATE (Carilion Materials Management), FENOFIBRATE (Carilion Materials Management), FENOFIBRATE (Clinical Solutions Wholesale), FENOFIBRATE (DirectRX), FENOFIBRATE (Dr. Reddy's Laboratories Limited), FENOFIBRATE (Global Pharmaceuticals), FENOFIBRATE (Impax Generics), FENOFIBRATE (Impax Generics), FENOFIBRATE (KAISER FOUNDATION HOSPITALS), FENOFIBRATE (Karalex Pharma LLC), FENOFIBRATE (LUPIN LIMITED), FENOFIBRATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), FENOFIBRATE (Lake Erie Medical DBA Quality Care Products LLC), FENOFIBRATE (Lake Erie Medical DBA Quality Care Products LLC), FENOFIBRATE (Lupin Pharmaceuticals), FENOFIBRATE (Lupin Pharmaceuticals), FENOFIBRATE (Lupin Pharmaceuticals), FENOFIBRATE (Mylan Institutional), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (NCS HealthCare of KY), FENOFIBRATE (NORTHWIND PHARMACEUTICALS), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Perrigo New York), FENOFIBRATE (Physicians Total Care), FENOFIBRATE (Physicians Total Care), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (Ranbaxy Pharmaceuticals), FENOFIBRATE (Ranbaxy Pharmaceuticals), FENOFIBRATE (St Marys Medical Park Pharmacy), FENOFIBRATE (St Marys Medical Park Pharmacy), FENOFIBRATE (St Marys Medical Park Pharmacy), FENOFIBRATE (Teva Pharmaceuticals USA), LOFIBRA (Teva Select Brands), LOFIBRA (Teva Select Brands), FENOFIBRATE (Unit Dose Services), FENOFIBRATE (Unit Dose Services), FENOFIBRATE (Unit Dose Services), FENOFIBRATE (Unit Dose Services), FENOFIBRATE (Zydus Pharmaceuticals USA), FENOFIBRIC ACID (Actavis Pharma), FENOFIBRIC ACID (Mutual Pharmaceutical Company), FENOFIBRIC ACID (Mylan Institutional), FENOFIBRIC ACID (Mylan Pharmaceuticals), FENOFIBRIC ACID (Zydus Pharmaceuticals USA)
Formula
C20H21ClO4
Exact mass
360.1128
Mol weight
360.8313
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01733  PPAR agonist
  DG01547  Fibrates
Cyp inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihyperlipidemic
  Disease
Hypertriglyceridemia
Target
peroxisome proliferator-activated receptor (PPAR) alpha [HSA:5465] [KO:K07294]
  Pathway
PPAR signaling pathway
Adipocytokine signaling pathway
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB1 [HSA:5243], ABCC2 [HSA:1244]
Drug interaction
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB05 Fenofibrate
      D00565  Fenofibrate (JAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Fibric Acid Derivatives
   Fenofibrate/Fenofibric Acid
    D00565  Fenofibrate (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2183  Clofibrates
     D00565  Fenofibrate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha
     Fenofibrate
      D00565  Fenofibrate (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C9
   Fenofibrate
    D00565  Fenofibrate (JAN/INN)
 Transporter inhibitors
  ABCB1
   Fenofibrate
    D00565  Fenofibrate (JAN/INN)
  ABCC2
   Fenofibrate
    D00565  Fenofibrate (JAN/INN)
Hypolipidemic agents [br08365.html]
 D00565
BRITE hierarchy
Other DBs
CAS: 
49562-28-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    29.4485  -16.2910
            2   C5a C    28.2596  -16.9904
            3   C8x C    30.7073  -16.9904
            4   C8x C    29.4485  -14.8924
            5   C8y C    27.0708  -16.2910
            6   O5a O    28.2596  -18.3890
            7   C8x C    31.8961  -16.2910
            8   C8x C    30.7073  -14.1930
            9   C8x C    25.8120  -16.9904
            10  C8x C    27.0708  -14.8924
            11  C8y C    31.8961  -14.8924
            12  C8x C    24.6231  -16.2910
            13  C8x C    25.8120  -14.1930
            14  O2a O    33.0850  -14.1930
            15  C8y C    24.6231  -14.8924
            16  C1d C    34.3438  -14.8924
            17  X   Cl   23.4343  -14.1930
            18  C7a C    35.5326  -14.1930
            19  O7a O    36.7215  -14.8924
            20  O6a O    35.5326  -12.7943
            21  C1c C    37.9804  -14.1930
            22  C1a C    39.1692  -14.8924
            23  C1a C    37.9804  -12.7943
            24  C1a C    33.6445  -16.1036
            25  C1a C    35.0431  -16.1036
BOND        26
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 2
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   18  20 2
            20   19  21 1
            21   21  22 1
            22   21  23 1
            23    8  11 1
            24   13  15 1
            25   16  24 1
            26   16  25 1

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