KEGG   DRUG: D00573Help
Entry
D00573                      Drug                                   

Name
Goserelin acetate (JAN/USP);
Zoladex (TN)
Product
Formula
C59H84N18O14. (C2H4O2)x
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
LHRH agonist [DS:H00024 H00031]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Goserelin cause downregulation of gonadotropin-releasing hormone (GnRH) receptor.
Target
gonadotropin-releasing hormone (GnRH) receptor agonist [HSA:2798] [KO:K04280]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04912  GnRH signaling pathway  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AE Gonadotropin releasing hormone analogues
     L02AE03 Goserelin
      D00573  Goserelin acetate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D00573  Goserelin acetate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Gonadotropin-releasing hormone
    gonadotropin-releasing hormone (GnRH) receptor
     Goserelin
      D00573  Goserelin acetate (JAN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Lutenizing hormone-releasing hormone agonist
   Goserelin
    D00573  Goserelin acetate (JAN)
BRITE hierarchy
Other DBs
CAS: 
145781-92-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        95
            1   C6a C    43.0248  -27.7517
            2   O6a O    44.2380  -28.4521
            3   C1a C    41.8118  -28.4521
            4   O6a O    43.0248  -26.3510
            5   C8y C    20.5100  -20.2300
            6   C8y C    21.0000  -18.9000
            7   C1b C    19.3200  -20.9300
            8   C8x C    21.7000  -21.0700
            9   C8y C    22.4000  -18.9000
            10  C8x C    20.3000  -17.6400
            11  C1c C    19.3200  -22.3300
            12  N4x N    22.8200  -20.2300
            13  C8x C    23.1000  -17.6400
            14  C8x C    21.0700  -16.4500
            15  N1b N    18.1300  -23.0300
            16  C5a C    20.5100  -23.0300
            17  C8x C    22.4000  -16.4500
            18  C5a C    16.8700  -22.3300
            19  N1b N    21.7700  -22.3300
            20  O5a O    20.5100  -24.4300
            21  C1c C    15.6800  -23.0300
            22  O5a O    16.8700  -20.9300
            23  C1c C    22.9600  -23.0300
            24  C1b C    15.6800  -24.4300
            25  N1b N    14.4900  -22.3300
            26  C5a C    24.2200  -22.3300
            27  C1b C    22.9600  -24.4300
            28  C8y C    16.8700  -25.0600
            29  C5a C    13.3000  -23.0300
            30  N1b N    25.4100  -23.0300
            31  O5a O    24.2200  -20.9300
            32  O1a O    24.2200  -25.0600
            33  C8x C    18.2700  -24.7100
            34  N5x N    16.8700  -26.5300
            35  C1y C    12.0400  -22.3300
            36  O5a O    13.3000  -24.4300
            37  C1c C    26.6000  -22.3300
            38  N4x N    18.9700  -25.9000
            39  C8x C    18.1300  -27.0200
            40  C1x C    10.7100  -22.7500
            41  N1x N    12.0400  -20.9300
            42  C1b C    26.6000  -20.9300
            43  C5a C    27.7900  -23.0300
            44  C1x C     9.8700  -21.6300
            45  C5x C    10.7100  -20.5100
            46  C8y C    27.7900  -20.2300
            47  N1b N    29.0500  -22.3300
            48  O5a O    27.7900  -24.4300
            49  O5x O    10.2900  -19.1800
            50  C8x C    29.0500  -20.9300
            51  C8x C    27.7900  -18.8300
            52  C1c C    30.2400  -23.0300
            53  C8x C    30.2400  -20.2300
            54  C8x C    29.0500  -18.1300
            55  C5a C    31.5000  -22.3300
            56  C1b C    30.2400  -24.4300
            57  C8y C    30.2400  -18.8300
            58  N1b N    32.6900  -23.0300
            59  O5a O    31.5000  -20.9300
            60  O2a O    29.0500  -25.0600
            61  O1a O    31.4300  -18.1300
            62  C1c C    33.8800  -22.3300
            63  C1d C    29.0500  -26.5300
            64  C5a C    35.0700  -23.0300
            65  C1b C    33.8800  -20.9300
            66  C1a C    29.0500  -28.0000
            67  C1a C    30.4500  -26.5300
            68  C1a C    27.7200  -26.5300
            69  N1b N    36.2600  -22.3300
            70  O5a O    35.0700  -24.4300
            71  C1c C    35.0700  -20.2300
            72  C1c C    37.5200  -23.0300
            73  C1a C    35.0700  -18.8300
            74  C1a C    36.2600  -20.9300
            75  C5a C    38.7800  -22.3300
            76  C1b C    37.5200  -24.4300
            77  N1y N    39.9700  -23.0300
            78  O5a O    38.7800  -20.9300
            79  C1b C    36.2600  -25.0600
            80  C1y C    41.3700  -23.0300
            81  C1x C    39.5500  -24.3600
            82  C1b C    36.2600  -26.5300
            83  C1x C    41.7900  -24.2900
            84  C5a C    42.5600  -22.2600
            85  C1x C    40.6700  -25.1300
            86  N1b N    35.0700  -27.2300
            87  N1b N    43.7500  -22.9600
            88  O5a O    42.5600  -20.9300
            89  C2c C    33.8800  -26.5300
            90  N1a N    32.6900  -27.2300
            91  N2a N    33.8800  -25.0600
            92  N1b N    45.0100  -22.2600
            93  C5a C    46.2000  -22.9600
            94  N1a N    47.3900  -22.2600
            95  O5a O    46.2000  -24.3600
BOND        99
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     5   6 1
            5     5   7 1
            6     5   8 2
            7     6   9 2
            8     6  10 1
            9     7  11 1
            10    8  12 1
            11    9  13 1
            12   10  14 2
            13   11  15 1
            14   11  16 1 #Up
            15   13  17 2
            16   15  18 1
            17   16  19 1
            18   16  20 2
            19   18  21 1
            20   18  22 2
            21   23  19 1 #Down
            22   21  24 1 #Down
            23   21  25 1
            24   23  26 1
            25   23  27 1
            26   24  28 1
            27   25  29 1
            28   26  30 1
            29   26  31 2
            30   27  32 1
            31   28  33 2
            32   28  34 1
            33   35  29 1 #Down
            34   29  36 2
            35   30  37 1
            36   33  38 1
            37   34  39 2
            38   35  40 1
            39   35  41 1
            40   37  42 1 #Up
            41   37  43 1
            42   40  44 1
            43   41  45 1
            44   42  46 1
            45   43  47 1
            46   43  48 2
            47   45  49 2
            48   46  50 2
            49   46  51 1
            50   47  52 1
            51   50  53 1
            52   51  54 2
            53   52  55 1
            54   52  56 1 #Up
            55   53  57 2
            56   55  58 1
            57   55  59 2
            58   56  60 1
            59   57  61 1
            60   58  62 1
            61   60  63 1
            62   62  64 1
            63   62  65 1 #Up
            64   63  66 1
            65   63  67 1
            66   63  68 1
            67   64  69 1
            68   64  70 2
            69   65  71 1
            70   69  72 1
            71   71  73 1
            72   71  74 1
            73   72  75 1
            74   72  76 1 #Down
            75   75  77 1
            76   75  78 2
            77   76  79 1
            78   77  80 1
            79   77  81 1
            80   79  82 1
            81   80  83 1
            82   80  84 1 #Down
            83   81  85 1
            84   82  86 1
            85   84  87 1
            86   84  88 2
            87   86  89 1
            88   89  90 1
            89   89  91 2
            90    9  12 1
            91   14  17 1
            92   38  39 1
            93   44  45 1
            94   54  57 1
            95   83  85 1
            96   87  92 1
            97   92  93 1
            98   93  94 1
            99   93  95 2
BRACKET     1    39.8300  -29.2600   39.8300  -25.5500
            1    45.7100  -25.5500   45.7100  -29.2600
            1  x
 ORIGINAL  1    1   2   3   4
 REPEAT    1

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