| Entry |
|
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| Name |
Voriconazole (JAN/USAN/INN);
Vfend (TN)
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| Product |
|
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| Generic |
|
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| Formula |
C16H14F3N5O
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| Exact mass |
349.115
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| Mol weight |
349.3105
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| Structure |
     |
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| Activity |
|
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
sterol 14alpha-demethylase ihibitor [KO: K05917] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
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| Interaction |
Genomic biomarker: CYP2C19 [HSA: 1557]
CYP inhibition: CYP3A [KO: K07424], CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557]
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| Structure map |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
617 Acting mainly on mold
6179 Others
D00578 Voriconazole (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AC Triazole derivatives
J02AC03 Voriconazole
D00578 Voriconazole (JAN/USAN/INN)
USP drug classification [BR:br08302]
Antifungals
Antifungals, Systemic
Azole Antifungals
Voriconazole
D00578 Voriconazole (JAN/USAN/INN)
Antiinfectives [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
sterol 14alpha-demethylase inhibitor [KO:K05917]
Triazoles
Voriconazole [ATC:J02AC03]
D00578 Voriconazole (JAN/USAN/INN)
 |
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| Other DBs |
CAS: 137234-62-9 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 25
1 C1d C 25.0014 -20.8416
2 C8y C 25.0014 -18.5274
3 C1c C 23.8241 -21.5118
4 C1b C 26.1673 -21.5178
5 O1a O 25.0014 -22.1939
6 C8y C 26.1614 -17.8513
7 C8x C 23.8241 -17.8513
8 C8y C 22.6232 -20.8240
9 C1a C 23.8181 -22.8992
10 N4y N 27.3447 -20.8357
11 C8x C 26.1614 -16.5049
12 X F 27.3389 -18.5274
13 C8x C 23.8241 -16.5049
14 C8y C 21.4225 -21.5118
15 N5x N 22.6349 -19.4367
16 C8x C 27.4030 -19.4950
17 N5x N 28.5688 -21.3895
18 C8y C 25.0014 -15.8228
19 C8x C 20.2216 -20.8183
20 X F 21.4225 -22.8992
21 C8x C 21.4283 -18.7374
22 N5x N 28.7960 -19.2095
23 C8x C 29.4839 -20.3869
24 X F 25.0014 -14.4647
25 N5x N 20.2216 -19.4310
BOND 27
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Down
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 6 11 1
11 6 12 1
12 7 13 2
13 8 14 1
14 8 15 2
15 10 16 1
16 10 17 1
17 11 18 2
18 14 19 2
19 14 20 1
20 15 21 1
21 16 22 2
22 17 23 2
23 18 24 1
24 19 25 1
25 13 18 1
26 21 25 2
27 22 23 1
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