KEGG   DRUG: D00586Help
Entry
D00586                      Drug                                   

Name
Flutamide (JP16/USP/INN);
Eulexin (TN)
Product
  Generic
Formula
C11H11F3N2O3
Exact mass
276.0722
Mol weight
276.2119
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiandrogen [DS:H00024]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
androgen receptor antagonist [HSA:367] [KO:K08557]
  Pathway
hsa05200  Pathways in cancer
hsa05215  Prostate cancer  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00586  Flutamide (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BB Anti-androgens
     L02BB01 Flutamide
      D00586  Flutamide (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Antiandrogens
   Flutamide
    D00586  Flutamide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    androgen receptor [HSA:367] [KO:K08557]
     Flutamide [ATC:L02BB01]
      D00586  Flutamide (JP16/USP/INN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonist
  Androgen antagonist
   Flutamide [ATC:L02BB01]
    D00586  Flutamide (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
13311-84-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8x C    37.5200  -20.3000
            2   C8y C    38.7100  -19.6700
            3   C8x C    36.2600  -19.6700
            4   C8y C    38.7100  -18.2700
            5   N2b N    39.9000  -20.3000 #+
            6   C8y C    36.2600  -18.2700
            7   C8x C    37.5200  -17.5700
            8   O3a O    39.9000  -21.7000
            9   O3a O    41.1600  -19.6000 #-
            10  N1b N    35.0700  -17.5700
            11  C5a C    33.8800  -18.2700
            12  C1c C    32.6900  -17.5700
            13  O5a O    33.8800  -19.6000
            14  C1a C    31.4300  -18.2700
            15  C1a C    32.6900  -16.1700
            16  C1d C    39.9253  -17.5749
            17  X   F    41.1377  -16.8749
            18  X   F    39.2253  -16.3625
            19  X   F    40.6253  -18.7874
BOND        19
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 2
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 2
            13   12  14 1
            14   12  15 1
            15    6   7 1
            16    4  16 1
            17   16  17 1
            18   16  18 1
            19   16  19 1

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