KEGG   DRUG: D00588Help
Entry
D00588                      Drug                                   
Name
Levofloxacin hydrate (JP16);
Levofloxacin (USAN);
LVFX;
Iquix (TN);
Levaquin (TN);
Quixin (TN)
Product
  Generic
LEVOFLOXACIN (Akorn), LEVOFLOXACIN (Akorn), LEVOFLOXACIN (American Health Packaging), LEVOFLOXACIN (AuroMedics Pharma LLC), LEVOFLOXACIN (Aurobindo Pharma Limited), LEVOFLOXACIN (Boca Pharmacal), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Cadila Healthcare Limited), LEVOFLOXACIN (Cardinal Health), LEVOFLOXACIN (Dr. Reddy's Laboratories Limited), LEVOFLOXACIN (Greenstone LLC), LEVOFLOXACIN (H.J. Harkins Company), LEVOFLOXACIN (Heritage Pharmaceuticals), LEVOFLOXACIN (Hi-Tech Pharmacal), LEVOFLOXACIN (Hi-Tech Pharmacal), LEVOFLOXACIN (Lake Erie Medical DBA Quality Care Products LLC), LEVOFLOXACIN (Lake Erie Medical DBA Quality Care Products LLC), LEVOFLOXACIN (Lupin Pharmaceuticals), LEVOFLOXACIN (Macleods Pharmaceuticals Limited), LEVOFLOXACIN (Major Pharmaceuticals), LEVOFLOXACIN (Mylan Institutional), LEVOFLOXACIN (Mylan Pharmaceuticals), LEVOFLOXACIN (Northstar Rx LLC), LEVOFLOXACIN (PACK Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (Physicians Total Care), LEVOFLOXACIN (Preferred Pharmaceuticals), LEVOFLOXACIN (Preferred Pharmaceuticals), LEVOFLOXACIN (Preferred Pharmaceuticals), LEVOFLOXACIN (Preferred Pharmaceuticals), LEVOFLOXACIN (Preferred Pharmaceuticals), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (Rebel Distributors Corp), LEVOFLOXACIN (STAT RX USA LLC), LEVOFLOXACIN (Sagent Pharmaceuticals), LEVOFLOXACIN (Sagent Pharmaceuticals), LEVOFLOXACIN (Sagent Pharmaceuticals), LEVOFLOXACIN (Sandoz), LEVOFLOXACIN (Sandoz), LEVOFLOXACIN (Teva Pharmaceuticals USA), LEVOFLOXACIN (Torrent Pharmaceuticals Limited), LEVOFLOXACIN (Unit Dose Services), LEVOFLOXACIN (West-ward Pharmaceutical Corp), LEVOFLOXACIN (Wockhardt Limited), LEVOFLOXACIN (Wockhardt USA LLC.), LEVOFLOXACIN (Zydus Pharmaceuticals (USA))
Formula
(C18H20FN3O4)2. H2O
Exact mass
740.2981
Mol weight
740.7503
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Remark
Therapeutic category: 
ATC code: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621] [KO:K02622]
Metabolism
Transporter: SLCO1A2 [HSA:6579]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00588  Levofloxacin hydrate (JP16); Levofloxacin (USAN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00588  Levofloxacin hydrate (JP16); Levofloxacin (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA12 Levofloxacin
      D00588  Levofloxacin hydrate (JP16); Levofloxacin (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE05 Levofloxacin
      D00588  Levofloxacin hydrate (JP16); Levofloxacin (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Levofloxacin
    D00588  Levofloxacin hydrate (JP16); Levofloxacin (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor [KO:K02469 K02470 K02621 K02622]
    Fluoroquinolones
     Levofloxacin [ATC:J01MA12]
      D00588  Levofloxacin hydrate (JP16); Levofloxacin (USAN)
BRITE hierarchy
Other DBs
CAS: 
138199-71-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        53
            1   C8y C    25.5128  -19.2413
            2   C8y C    24.2948  -19.9406
            3   C8y C    25.5070  -17.8485
            4   N4y N    26.7249  -19.9406
            5   C8y C    23.0828  -19.2354
            6   O2x O    24.2948  -21.3449
            7   C8y C    26.7133  -17.1434
            8   C8x C    24.3007  -17.1318
            9   C8x C    27.9312  -19.2354
            10  C1y C    26.7249  -21.3449
            11  N1y N    21.8590  -19.9406
            12  C8y C    23.0828  -17.8311
            13  C1x C    25.5128  -22.0383
            14  C8y C    27.9312  -17.8368
            15  O5x O    26.7074  -15.7506
            16  C1a C    27.9312  -22.0442
            17  C1x C    21.8532  -21.3449
            18  C1x C    20.6470  -19.2296
            19  X   F    21.8590  -17.1434
            20  C6a C    29.1316  -17.1434
            21  C1x C    20.6353  -22.0325
            22  C1x C    19.4407  -19.9289
            23  O6a O    30.3378  -17.8427
            24  O6a O    29.1258  -15.7448
            25  N1y N    19.4290  -21.3333
            26  C1a C    18.2111  -22.0325
            27  O0  O    34.9829  -18.9205
            28  C8y C    25.5128  -19.2413
            29  C8y C    24.2948  -19.9406
            30  C8y C    23.0828  -19.2354
            31  N1y N    21.8590  -19.9406
            32  C1x C    21.8532  -21.3449
            33  C1x C    20.6353  -22.0325
            34  N1y N    19.4290  -21.3333
            35  C1a C    18.2111  -22.0325
            36  C1x C    19.4407  -19.9289
            37  C1x C    20.6470  -19.2296
            38  C8y C    23.0828  -17.8311
            39  C8x C    24.3007  -17.1318
            40  C8y C    25.5070  -17.8485
            41  C8y C    26.7133  -17.1434
            42  C8y C    27.9312  -17.8368
            43  C8x C    27.9312  -19.2354
            44  N4y N    26.7249  -19.9406
            45  C1y C    26.7249  -21.3449
            46  C1x C    25.5128  -22.0383
            47  O2x O    24.2948  -21.3449
            48  C1a C    27.9312  -22.0442
            49  C6a C    29.1316  -17.1434
            50  O6a O    30.3378  -17.8427
            51  O6a O    29.1258  -15.7448
            52  O5x O    26.7074  -15.7506
            53  X   F    21.8590  -17.1434
BOND        58
            1    25  26 1
            2     8  12 2
            3     9  14 2
            4    10  13 1
            5    22  25 1
            6     1   2 1
            7     1   3 2
            8     1   4 1
            9     2   5 2
            10    2   6 1
            11    3   7 1
            12    3   8 1
            13    4   9 1
            14    4  10 1
            15    5  11 1
            16    5  12 1
            17    6  13 1
            18    7  14 1
            19    7  15 2
            20   10  16 1 #Up
            21   11  17 1
            22   11  18 1
            23   12  19 1
            24   14  20 1
            25   17  21 1
            26   18  22 1
            27   20  23 1
            28   20  24 2
            29   21  25 1
            30   34  35 1
            31   39  38 2
            32   43  42 2
            33   45  46 1
            34   36  34 1
            35   28  29 1
            36   28  40 2
            37   28  44 1
            38   29  30 2
            39   29  47 1
            40   40  41 1
            41   40  39 1
            42   44  43 1
            43   44  45 1
            44   30  31 1
            45   30  38 1
            46   47  46 1
            47   41  42 1
            48   41  52 2
            49   45  48 1 #Up
            50   31  32 1
            51   31  37 1
            52   38  53 1
            53   42  49 1
            54   32  33 1
            55   37  36 1
            56   49  50 1
            57   49  51 2
            58   33  34 1
BRACKET     1    16.7300  -23.0300   16.7300  -15.1200
            1    31.5700  -15.1200   31.5700  -23.0300
            1  2
 ORIGINAL  1    1   2   5  11  17  21  25  26  22  18  12   8   3   7  14   9
            1    4  10  13   6  16  20  23  24  15  19
 REPEAT    1   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            1   44  45  46  47  48  49  50  51  52  53

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