KEGG   DRUG: GatifloxacinHelp
Entry
D00589                      Drug                                   

Name
Gatifloxacin (USAN);
Gatifloxacin hydrate (JAN);
GFLX;
Gatiflo (TN);
Tequin (TN);
Zymar (TN)
Product
  Generic
Formula
(C19H22FN3O4)2. 3H2O
Exact mass
804.3506
Mol weight
804.834
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antibacterial (opthalmic), Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA16 Gatifloxacin
      D00589  Gatifloxacin (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE06 Gatifloxacin
      D00589  Gatifloxacin (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Gatifloxacin
    D00589  Gatifloxacin (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00589  Gatifloxacin (USAN); Gatifloxacin hydrate (JAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Gatifloxacin
      D00589  Gatifloxacin (USAN)
Antibacterials [br08350.html]
 D00589
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00589
BRITE hierarchy
Other DBs
CAS: 
180200-66-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        57
            1   C8y C    19.7210  -14.3186
            2   N4y N    20.9389  -15.0120
            3   C8y C    19.7093  -12.9257
            4   C8y C    18.5145  -15.0296
            5   C1y C    20.9272  -16.4167
            6   C8x C    22.1396  -14.2952
            7   C8y C    20.9098  -12.2204
            8   C8x C    18.4969  -12.2263
            9   C8y C    17.3022  -14.3419
            10  O2a O    18.4969  -16.4401
            11  C1x C    21.6266  -17.6348
            12  C1x C    20.2163  -17.6232
            13  C8y C    22.1279  -12.9024
            14  O5x O    20.8982  -10.8159
            15  C8y C    17.2964  -12.9315
            16  N1y N    16.1714  -15.1169
            17  C1a C    17.5062  -17.4366
            18  C6a C    23.3344  -12.2030
            19  X   F    16.0783  -12.2380
            20  C1x C    16.1714  -16.5155
            21  C1x C    14.9592  -14.4233
            22  O6a O    24.5465  -12.9081
            23  O6a O    23.3284  -10.8042
            24  C1y C    14.9650  -17.2208
            25  C1x C    13.7469  -15.1169
            26  N1x N    13.7469  -16.5155
            27  C1a C    14.9475  -18.6196
            28  O0  O    29.5155  -15.4314
            29  C8y C    19.7210  -14.3186
            30  N4y N    20.9389  -15.0120
            31  C1y C    20.9272  -16.4167
            32  C1x C    21.6266  -17.6348
            33  C1x C    20.2163  -17.6232
            34  C8x C    22.1396  -14.2952
            35  C8y C    22.1279  -12.9024
            36  C6a C    23.3344  -12.2030
            37  O6a O    24.5465  -12.9081
            38  O6a O    23.3284  -10.8042
            39  C8y C    20.9098  -12.2204
            40  C8y C    19.7093  -12.9257
            41  C8x C    18.4969  -12.2263
            42  C8y C    17.2964  -12.9315
            43  C8y C    17.3022  -14.3419
            44  C8y C    18.5145  -15.0296
            45  O2a O    18.4969  -16.4401
            46  C1a C    17.5062  -17.4366
            47  N1y N    16.1714  -15.1169
            48  C1x C    16.1714  -16.5155
            49  C1y C    14.9650  -17.2208
            50  N1x N    13.7469  -16.5155
            51  C1x C    13.7469  -15.1169
            52  C1x C    14.9592  -14.4233
            53  C1a C    14.9475  -18.6196
            54  X   F    16.0783  -12.2380
            55  O5x O    20.8982  -10.8159
            56  O0  O    29.5155  -15.4314
            57  O0  O    29.5155  -15.4314
BOND        60
            1     9  15 2
            2    11  12 1
            3    25  26 1
            4     1   2 1
            5     1   3 1
            6     1   4 2
            7     2   5 1
            8     2   6 1
            9     3   7 1
            10    3   8 2
            11    4   9 1
            12    4  10 1
            13    5  11 1
            14    5  12 1
            15    6  13 2
            16    7  14 2
            17    8  15 1
            18    9  16 1
            19   10  17 1
            20   13  18 1
            21   15  19 1
            22   16  20 1
            23   16  21 1
            24   18  22 1
            25   18  23 2
            26   20  24 1
            27   21  25 1
            28   24  26 1
            29   24  27 1
            30    7  13 1
            31   43  42 2
            32   32  33 1
            33   51  50 1
            34   29  30 1
            35   29  40 1
            36   29  44 2
            37   30  31 1
            38   30  34 1
            39   40  39 1
            40   40  41 2
            41   44  43 1
            42   44  45 1
            43   31  32 1
            44   31  33 1
            45   34  35 2
            46   39  55 2
            47   41  42 1
            48   43  47 1
            49   45  46 1
            50   35  36 1
            51   42  54 1
            52   47  48 1
            53   47  52 1
            54   36  37 1
            55   36  38 2
            56   48  49 1
            57   52  51 1
            58   49  50 1
            59   49  53 1
            60   39  35 1
BRACKET     1    12.5300  -20.0900   12.5300   -9.7300
            1    25.8300   -9.7300   25.8300  -20.0900
            1  2
 ORIGINAL  1    1   2   5  11  12   6  13  18  22  23   7   3   8  15   9   4
            1   10  17  16  20  24  26  25  21  27  19  14
 REPEAT    1   29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44
            1   45  46  47  48  49  50  51  52  53  54  55
            2    27.8600  -16.5900   27.8600  -14.4900
            2    30.2400  -14.4900   30.2400  -16.5900
            2  3
 ORIGINAL  2   28
 REPEAT    2   56  57

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