KEGG   DRUG: D00589Help
Entry
D00589                      Drug                                   

Name
Gatifloxacin hydrate (JAN);
Gatifloxacin (USAN);
GFLX;
Gatiflo (TN);
Tequin (TN);
Zymar (TN)
Product
  Generic
Formula
(C19H22FN3O4)2. 3H2O
Exact mass
804.3506
Mol weight
804.834
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00589  Gatifloxacin hydrate (JAN); Gatifloxacin (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA16 Gatifloxacin
      D00589  Gatifloxacin hydrate (JAN); Gatifloxacin (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE06 Gatifloxacin
      D00589  Gatifloxacin hydrate (JAN); Gatifloxacin (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Gatifloxacin
    D00589  Gatifloxacin hydrate (JAN); Gatifloxacin (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor [KO:K02469 K02470 K02621 K02622]
    Fluoroquinolones
     Gatifloxacin [ATC:J01MA16]
      D00589  Gatifloxacin hydrate (JAN); Gatifloxacin (USAN)
BRITE hierarchy
Other DBs
CAS: 
180200-66-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        57
            1   C8y C    19.7210  -14.3186
            2   N4y N    20.9389  -15.0120
            3   C8y C    19.7093  -12.9257
            4   C8y C    18.5145  -15.0296
            5   C1y C    20.9272  -16.4167
            6   C8x C    22.1396  -14.2952
            7   C8y C    20.9098  -12.2204
            8   C8x C    18.4969  -12.2263
            9   C8y C    17.3022  -14.3419
            10  O2a O    18.4969  -16.4401
            11  C1x C    21.6266  -17.6348
            12  C1x C    20.2163  -17.6232
            13  C8y C    22.1279  -12.9024
            14  O5x O    20.8982  -10.8159
            15  C8y C    17.2964  -12.9315
            16  N1y N    16.1714  -15.1169
            17  C1a C    17.5062  -17.4366
            18  C6a C    23.3344  -12.2030
            19  X   F    16.0783  -12.2380
            20  C1x C    16.1714  -16.5155
            21  C1x C    14.9592  -14.4233
            22  O6a O    24.5465  -12.9081
            23  O6a O    23.3284  -10.8042
            24  C1y C    14.9650  -17.2208
            25  C1x C    13.7469  -15.1169
            26  N1x N    13.7469  -16.5155
            27  C1a C    14.9475  -18.6196
            28  O0  O    29.5155  -15.4314
            29  C8y C    19.7210  -14.3186
            30  N4y N    20.9389  -15.0120
            31  C1y C    20.9272  -16.4167
            32  C1x C    21.6266  -17.6348
            33  C1x C    20.2163  -17.6232
            34  C8x C    22.1396  -14.2952
            35  C8y C    22.1279  -12.9024
            36  C6a C    23.3344  -12.2030
            37  O6a O    24.5465  -12.9081
            38  O6a O    23.3284  -10.8042
            39  C8y C    20.9098  -12.2204
            40  C8y C    19.7093  -12.9257
            41  C8x C    18.4969  -12.2263
            42  C8y C    17.2964  -12.9315
            43  C8y C    17.3022  -14.3419
            44  C8y C    18.5145  -15.0296
            45  O2a O    18.4969  -16.4401
            46  C1a C    17.5062  -17.4366
            47  N1y N    16.1714  -15.1169
            48  C1x C    16.1714  -16.5155
            49  C1y C    14.9650  -17.2208
            50  N1x N    13.7469  -16.5155
            51  C1x C    13.7469  -15.1169
            52  C1x C    14.9592  -14.4233
            53  C1a C    14.9475  -18.6196
            54  X   F    16.0783  -12.2380
            55  O5x O    20.8982  -10.8159
            56  O0  O    29.5155  -15.4314
            57  O0  O    29.5155  -15.4314
BOND        60
            1     9  15 2
            2    11  12 1
            3    25  26 1
            4     1   2 1
            5     1   3 1
            6     1   4 2
            7     2   5 1
            8     2   6 1
            9     3   7 1
            10    3   8 2
            11    4   9 1
            12    4  10 1
            13    5  11 1
            14    5  12 1
            15    6  13 2
            16    7  14 2
            17    8  15 1
            18    9  16 1
            19   10  17 1
            20   13  18 1
            21   15  19 1
            22   16  20 1
            23   16  21 1
            24   18  22 1
            25   18  23 2
            26   20  24 1
            27   21  25 1
            28   24  26 1
            29   24  27 1
            30    7  13 1
            31   43  42 2
            32   32  33 1
            33   51  50 1
            34   29  30 1
            35   29  40 1
            36   29  44 2
            37   30  31 1
            38   30  34 1
            39   40  39 1
            40   40  41 2
            41   44  43 1
            42   44  45 1
            43   31  32 1
            44   31  33 1
            45   34  35 2
            46   39  55 2
            47   41  42 1
            48   43  47 1
            49   45  46 1
            50   35  36 1
            51   42  54 1
            52   47  48 1
            53   47  52 1
            54   36  37 1
            55   36  38 2
            56   48  49 1
            57   52  51 1
            58   49  50 1
            59   49  53 1
            60   39  35 1
BRACKET     1    12.5300  -20.0900   12.5300   -9.7300
            1    25.8300   -9.7300   25.8300  -20.0900
            1  2
 ORIGINAL  1    1   2   5  11  12   6  13  18  22  23   7   3   8  15   9   4
            1   10  17  16  20  24  26  25  21  27  19  14
 REPEAT    1   29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44
            1   45  46  47  48  49  50  51  52  53  54  55
            2    27.8600  -16.5900   27.8600  -14.4900
            2    30.2400  -14.4900   30.2400  -16.5900
            2  3
 ORIGINAL  2   28
 REPEAT    2   56  57

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