| Entry |
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| Name |
Diaphenylsulfone (JAN);
Dapsone (USP);
Aczone (TN)
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| Product |
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| Generic |
|
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| Formula |
C12H12N2O2S
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| Exact mass |
248.0619
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| Mol weight |
248.3009
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| Structure |
     |
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| Activity |
Antibacterial [leprostatic];
Suppressant [dermatitis herpetiformis] [DS: H00344]
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency [DS: H00668] are more prone to hemolysis with the use of Dapsone.
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| Target |
dihydropteroate synthase inhibitor [KO: K00796] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2E1 [HSA: 1571], CYP3A4 [HSA: 1576]
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| Interaction |
Genomic biomarker: G6PD [HSA: 2539]
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| Structure map |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
269 Miscellaneous
2699 Others
D00592 Diaphenylsulfone (JAN); Dapsone (USP)
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
623 Leprostatics
6231 Sulfones
D00592 Diaphenylsulfone (JAN); Dapsone (USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AX Other anti-acne preparations for topical use
D10AX05 Dapsone
D00592 Diaphenylsulfone (JAN); Dapsone (USP)
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04B DRUGS FOR TREATMENT OF LEPRA
J04BA Drugs for treatment of lepra
J04BA02 Dapsone
D00592 Diaphenylsulfone (JAN); Dapsone (USP)
USP drug classification [BR:br08302]
Antimycobacterials
Antimycobacterials, Other
Dapsone
D00592 Diaphenylsulfone (JAN); Dapsone (USP)
Antiinfectives [BR:br08307]
Antibacterials
Folic acid biosynthesis inhibitor
dihydropteroate synthase inhibitor [KO:K00796]
Others
Dapsone; Antileprosy drug [ATC:J04BA02]
D00592 Diaphenylsulfone (JAN); Dapsone (USP)
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| Other DBs |
CAS: 80-08-0 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 17
1 S4a S 21.9800 -14.6136
2 C8y C 23.1922 -15.3246
3 C8y C 20.7736 -15.3187
4 O3c O 20.9776 -13.6228
5 O3c O 22.9708 -13.6228
6 C8x C 24.4045 -14.6195
7 C8x C 23.1922 -16.7234
8 C8x C 19.5614 -14.6136
9 C8x C 20.7736 -16.7175
10 C8x C 25.6050 -15.3187
11 C8x C 24.4045 -17.4168
12 C8x C 18.3433 -15.3187
13 C8x C 19.5614 -17.4168
14 C8y C 25.6167 -16.7234
15 C8y C 18.3433 -16.7175
16 N1a N 26.8174 -17.4285
17 N1a N 17.1369 -17.4168
BOND 18
1 1 2 1
2 1 3 1
3 1 4 2
4 1 5 2
5 2 6 2
6 2 7 1
7 3 8 2
8 3 9 1
9 6 10 1
10 7 11 2
11 8 12 1
12 9 13 2
13 10 14 2
14 12 15 2
15 14 16 1
16 15 17 1
17 11 14 1
18 13 15 1
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