KEGG   DRUG: BuforminHelp
Entry
D00595                      Drug                                   

Name
Buformin (USAN/INN)
Formula
C6H15N5
Exact mass
157.1327
Mol weight
157.2168
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Same as: C07674
ATC code: A10BA03
Chemical structure group: DG00114
Product (DG00114): D02206<JP>
Efficacy
Antidiabetic, Hypoglycemic
Comment
Biguanide
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA03 Buformin
      D00595  Buformin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CAMKL family
    AMPK (PRKAA)
     D00595  Buformin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 692-13-7
PubChem: 7847661
ChEBI: 3209
ChEMBL: CHEMBL39736
DrugBank: DB04830
PDB-CCD: BFR[PDBj]
LigandBox: D00595
NIKKAJI: J9.453F
KCF data Show

ATOM        11
            1   N1b N    21.2128  -16.3163
            2   C2c C    19.9976  -17.0197
            3   C1b C    22.4221  -17.0197
            4   N1b N    18.7881  -16.3163
            5   N2a N    19.9976  -18.4210
            6   C1b C    23.6372  -16.3163
            7   C2c C    17.5788  -17.0197
            8   C1b C    24.8465  -17.0197
            9   N1a N    16.3695  -16.3163
            10  N2a N    17.5788  -18.4210
            11  C1a C    26.0501  -16.3163
BOND        10
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1

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