| Entry |
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| Name |
Rosiglitazone maleate (JAN/USAN);
Avandia (TN)
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| Product |
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| Formula |
C18H19N3O3S. C4H4O4
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| Exact mass |
473.1257
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| Mol weight |
473.4989
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| Structure |
     |
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| Activity |
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| Remark |
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| Target |
peroxisome proliferator-activated receptor (PPAR) gamma agonist [HSA: 5468] [KO: K08530] |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C8 [HSA: 1558], CYP2C9 [HSA: 1559]
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| Interaction |
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| Structure map |
| Peroxisome proliferator-activated receptor (PPAR) agonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BG Thiazolidinediones
A10BG02 Rosiglitazone
D00596 Rosiglitazone maleate (JAN/USAN)
USP drug classification [BR:br08302]
Blood Glucose Regulators
Antidiabetic Agents
Thiazolidinediones
Rosiglitazone
D00596 Rosiglitazone maleate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
Rosiglitazone [ATC:A10BG02]
D00596 Rosiglitazone maleate (JAN/USAN)
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| Other DBs |
CAS: 155141-29-0 PubChem: DrugBank: LigandBox: |
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| KCF data |
ATOM 33
1 C1y C 36.8941 -13.6110
2 C1b C 35.6829 -12.9146
3 S2x S 38.2201 -13.1736
4 C5x C 36.9094 -15.0237
5 C8y C 34.4717 -13.6110
6 C5x C 39.0590 -14.2996
7 N1x N 38.2452 -15.4388
8 O5x O 35.7838 -15.8568
9 C8x C 33.2605 -12.9146
10 C8x C 34.4717 -15.0153
11 O5x O 40.4533 -14.2854
12 C8x C 32.0493 -13.6110
13 C8x C 33.2605 -15.7115
14 C8y C 32.0493 -15.0153
15 O2a O 30.8323 -15.7115
16 C1b C 29.6211 -15.0153
17 C1b C 28.4099 -15.7115
18 N1c N 27.1987 -15.0153
19 C8y C 25.9875 -15.7115
20 C1a C 27.1987 -13.6110
21 C8x C 25.9933 -17.1217
22 N5x N 24.7763 -15.0211
23 C8x C 24.7763 -17.8179
24 C8x C 23.5651 -15.7174
25 C8x C 23.5651 -17.1217
26 C6a C 34.3185 -20.2162
27 C2b C 33.6434 -19.0515
28 O6a O 33.7189 -21.4564
29 O6a O 35.6691 -20.2099
30 C2b C 32.0265 -19.0577
31 C6a C 31.3575 -20.2285
32 O6a O 30.0069 -20.2285
33 O6a O 32.0390 -21.4625
BOND 34
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 4 8 2
8 5 9 2
9 5 10 1
10 6 11 2
11 9 12 1
12 10 13 2
13 12 14 2
14 14 15 1
15 15 16 1
16 16 17 1
17 17 18 1
18 18 19 1
19 18 20 1
20 19 21 1
21 19 22 2
22 21 23 2
23 22 24 1
24 23 25 1
25 6 7 1
26 13 14 1
27 24 25 2
28 26 27 1
29 26 28 1
30 26 29 2
31 27 30 2
32 30 31 1
33 31 32 1
34 31 33 2
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