KEGG   DRUG: D00598Help
Entry
D00598                      Drug                                   

Name
Betaxolol hydrochloride (JP16/USP);
Betoptic (TN);
Kerlone (TN)
Product
  Generic
Formula
C18H29NO3. HCl
Exact mass
343.1914
Mol weight
343.8887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anginal;
Antihypertensive [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB05 Betaxolol
      D00598  Betaxolol hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED02 Betaxolol
      D00598  Betaxolol hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Betaxolol
    D00598  Betaxolol hydrochloride (JP16/USP)
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Betaxolol
    D00598  Betaxolol hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00598  Betaxolol hydrochloride (JP16/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00598  Betaxolol hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Betaxolol
      D00598  Betaxolol hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00598  Betaxolol hydrochloride
BRITE hierarchy
Other DBs
CAS: 
63659-19-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   O2a O    18.6200  -17.2900
            2   C1b C    19.8100  -16.5900
            3   C1c C    21.0700  -17.2900
            4   C1b C    22.2600  -16.5900
            5   O1a O    21.0700  -18.6900
            6   N1b N    23.4500  -17.2900
            7   C1c C    24.7100  -16.5900
            8   C1a C    25.9000  -17.2900
            9   C1a C    24.7100  -15.1900
            10  C8y C    18.6200  -18.6900
            11  C8x C    17.4300  -19.3900
            12  C8x C    17.4300  -20.7900
            13  C8y C    18.6200  -21.4900
            14  C8x C    19.8100  -20.7900
            15  C8x C    19.8100  -19.3900
            16  C1b C    18.6200  -22.8900
            17  C1b C    17.4300  -23.6600
            18  O2a O    16.2400  -22.9600
            19  C1b C    15.0500  -23.6600
            20  C1y C    13.7900  -23.0300
            21  C1x C    12.3900  -23.0300
            22  C1x C    13.0900  -21.8400
            23  X   Cl   25.7680  -23.2778
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     7   9 1
            9     1  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   10  15 1
            16   13  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   21  20 1
            22   22  21 1
            23   22  20 1

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