KEGG   DRUG: D00598Help
Entry
D00598                      Drug                                   

Name
Betaxolol hydrochloride (JP16/USP);
Betoptic (TN);
Kerlone (TN)
Product
  Generic
Formula
C18H29NO3. HCl
Exact mass
343.1914
Mol weight
343.8887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anginal;
Antihypertensive [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00598  Betaxolol hydrochloride (JP16/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00598  Betaxolol hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB05 Betaxolol
      D00598  Betaxolol hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED02 Betaxolol
      D00598  Betaxolol hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Betaxolol
    D00598  Betaxolol hydrochloride (JP16/USP)
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Betaxolol
    D00598  Betaxolol hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Betaxolol [ATC:C07AB05 S01ED02]
      D00598  Betaxolol hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
63659-19-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    20.0139  -17.7348
            2   C8x C    18.8011  -18.4303
            3   C8x C    20.0261  -16.3374
            4   O2a O    21.2203  -18.4489
            5   C8x C    17.5947  -17.7286
            6   C8x C    18.8197  -15.6357
            7   C1b C    22.4330  -17.7532
            8   C8y C    17.6008  -16.3251
            9   C1c C    23.6395  -18.4672
            10  C1b C    16.3881  -15.6296
            11  C1b C    24.8582  -17.7718
            12  O1a O    23.6333  -19.8707
            13  C1b C    15.1755  -16.3251
            14  N1b N    26.0711  -18.4858
            15  O2a O    13.9566  -15.6296
            16  C1c C    27.2898  -17.7901
            17  C1b C    12.7502  -16.3251
            18  C1a C    28.4963  -18.5042
            19  C1a C    27.3021  -16.3929
            20  C1y C    11.5376  -15.6296
            21  C1x C    10.2941  -16.2698
            22  C1x C    10.3556  -14.8723
            23  X   Cl   32.2082  -18.0979
BOND        23
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1
            19   17  20 1
            20   20  21 1
            21   20  22 1
            22    6   8 2
            23   21  22 1

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