KEGG   DRUG: D00600Help
Entry
D00600                      Drug                                   
Name
Labetalol hydrochloride (JP16/USP);
Normodyne (TN);
Trandate (TN)
Product
  Generic
LABETALOL HYDROCHLORIDE (Mylan Institutional LLC), LABETALOL HCL (Cardinal Health), LABETALOL HCL (Eon Labs), LABETALOL HCL (McKesson Packaging Services a business unit of McKesson Corporation), LABETALOL HCL (UDL Laboratories), LABETALOL HYDROCHLORIDE (Akorn), LABETALOL HYDROCHLORIDE (American Health Packaging), LABETALOL HYDROCHLORIDE (Bedford Laboratories), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Dispensing Solutions), LABETALOL HYDROCHLORIDE (Gland Pharma Limited), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (IVAX Pharmaceuticals), LABETALOL HYDROCHLORIDE (Major Pharmaceuticals), LABETALOL HYDROCHLORIDE (McKesson Contract Packaging), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HCL (Par Pharmaceutical Companies), LABETALOL HYDROCHLORIDE (Physicians Total Care), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (Rebel Distributors Corp), LABETALOL HYDROCHLORIDE (Rebel Distributors Corp), LABETALOL HYDROCHLORIDE (STAT RX USA LLC), LABETALOL (Sagent Pharmaceuticals), LABETALOL HYDROCHLORIDE (Watson Laboratories)
  Other
Formula
C19H24N2O3. HCl
Exact mass
364.1554
Mol weight
364.8664
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [alpha-receptor];
Anti-adrenergic [beta-receptor]
Remark
Therapeutic category: 
ATC code: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00600  Labetalol hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG01 Labetalol
      D00600  Labetalol hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Labetalol
    D00600  Labetalol hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Labetalol [ATC:C07AG01]
      D00600  Labetalol hydrochloride (JP16/USP)
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Labetalol [ATC:C07AG01]
      D00600  Labetalol hydrochloride (JP16/USP)
    beta2-adrenergic receptor [HSA:154] [KO:K04142]
     Labetalol [ATC:C07AG01]
      D00600  Labetalol hydrochloride (JP16/USP)
    beta3-adrenergic receptor [HSA:155] [KO:K04143]
     Labetalol [ATC:C07AG01]
      D00600  Labetalol hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
32780-64-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    24.6466  -15.7558
            2   C8y C    24.6466  -17.1568
            3   C8x C    25.8600  -17.8573
            4   C8x C    27.0733  -17.1568
            5   C8y C    27.0733  -15.7558
            6   C8x C    25.8600  -15.0552
            7   C1c C    28.3118  -15.0552
            8   C1b C    29.5252  -15.7558
            9   N1b N    30.7385  -15.0552
            10  C1c C    31.9518  -15.7558
            11  C1b C    33.1652  -15.0552
            12  C1b C    34.3785  -15.7558
            13  C8y C    35.5918  -15.0552
            14  C5a C    23.4333  -15.0552
            15  N1a N    22.2369  -15.7462
            16  O5a O    23.4332  -13.6544
            17  O1a O    23.4333  -17.8573
            18  O1a O    28.2480  -13.6545
            19  C1a C    31.9518  -17.1567
            20  C8x C    36.7923  -15.7485
            21  C8x C    38.0057  -15.0480
            22  C8x C    38.0058  -13.6470
            23  C8x C    36.8054  -12.9537
            24  C8x C    35.5919  -13.6542
            25  X   Cl   35.9951  -17.1568
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    1  14 1
            15   14  15 1
            16   14  16 2
            17    2  17 1
            18    7  18 1
            19   10  19 1
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1

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