KEGG   DRUG: Labetalol hydrochlorideHelp
Entry
D00600                      Drug                                   

Name
Labetalol hydrochloride (JP17/USP);
Normodyne (TN);
Trandate (TN)
Product
  Generic
LABETALOL HYDROCHLORIDE (Mylan Institutional LLC), LABETALOL (Sun Pharmaceutical Industries), LABETALOL HCL (American Health Packaging), LABETALOL HCL (BluePoint Laboratories), LABETALOL HCL (Cardinal Health), LABETALOL HCL (Cardinal Health), LABETALOL HCL (Eon Labs), LABETALOL HCL (McKesson Packaging Services a business unit of McKesson Corporation), LABETALOL HCL (Mylan Institutional), LABETALOL HCL (REMEDYREPACK), LABETALOL HCL (REMEDYREPACK), LABETALOL HCL (A-S Medication Solutions), LABETALOL HCL (A-S Medication Solutions), LABETALOL HYDROCHLORIDE (Actavis Pharma), LABETALOL HYDROCHLORIDE (Akorn), LABETALOL HYDROCHLORIDE (American Health Packaging), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Dispensing Solutions), LABETALOL HYDROCHLORIDE (Gland Pharma Limited), LABETALOL HYDROCHLORIDE (Golden State Medical Supply), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (IVAX Pharmaceuticals), LABETALOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), LABETALOL HYDROCHLORIDE (Major Pharmaceuticals), LABETALOL HYDROCHLORIDE (McKesson Contract Packaging), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HCL (Par Pharmaceutical), LABETALOL HYDROCHLORIDE (Physicians Total Care), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HCL (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (Rebel Distributors Corp), LABETALOL HYDROCHLORIDE (Rebel Distributors Corp), LABETALOL HYDROCHLORIDE (STAT RX USA LLC), LABETALOL (Sagent Pharmaceuticals), LABETALOL HYDROCHLORIDE (St Marys Medical Park Pharmacy), LABETALOL HYDROCHLORIDE (Unit Dose Services), LABETALOL HYDROCHLORIDE (Unit Dose Services)
  Other
Formula
C19H24N2O3. HCl
Exact mass
364.1554
Mol weight
364.8664
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, alpha1 and beta-Adrenergic receptor antagonist
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137];
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG01 Labetalol
      D00600  Labetalol hydrochloride (JP17/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Labetalol
    D00600  Labetalol hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00600  Labetalol hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP17/USP)
    beta1-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP17/USP)
    beta2-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP17/USP)
    beta3-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Labetalol
    D00600  Labetalol hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00600  Labetalol hydrochloride
  D00600  Labetalol hydrochloride tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00600
BRITE hierarchy
Other DBs
CAS: 
32780-64-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    13.1600  -15.8200
            2   C8y C    13.1600  -14.4200
            3   C8x C    14.3500  -13.7200
            4   C8x C    15.6100  -14.4200
            5   C8y C    15.6100  -15.8200
            6   C8x C    14.3500  -16.5200
            7   C1c C    16.8000  -16.5200
            8   C1b C    18.0600  -15.8200
            9   N1b N    19.2500  -16.5200
            10  C1c C    20.4400  -15.8200
            11  C1b C    21.7000  -16.5200
            12  C1b C    22.8900  -15.8200
            13  C8y C    24.0800  -16.5200
            14  C5a C    11.9700  -16.5200
            15  N1a N    10.7800  -15.8200
            16  O5a O    11.9700  -17.9200
            17  O1a O    11.9700  -13.7200
            18  O1a O    16.8000  -17.9200
            19  C1a C    20.4400  -14.4200
            20  C8x C    25.3400  -15.8200
            21  C8x C    26.5300  -16.5200
            22  C8x C    26.5300  -17.9200
            23  C8x C    25.3400  -18.6200
            24  C8x C    24.0800  -17.9200
            25  X   Cl   25.6900  -13.6500
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    1  14 1
            15   14  15 1
            16   14  16 2
            17    2  17 1
            18    7  18 1
            19   10  19 1
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1

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