KEGG   DRUG: D00600Help
Entry
D00600                      Drug                                   

Name
Labetalol hydrochloride (JP16/USP);
Normodyne (TN);
Trandate (TN)
Product
  Generic
LABETALOL HYDROCHLORIDE (Mylan Institutional LLC), LABETALOL (Sun Pharmaceutical Industries), LABETALOL HCL (BluePoint Laboratories), LABETALOL HCL (Cardinal Health), LABETALOL HCL (Cardinal Health), LABETALOL HCL (Eon Labs), LABETALOL HCL (McKesson Packaging Services a business unit of McKesson Corporation), LABETALOL HCL (Mylan Institutional), LABETALOL HCL (REMEDYREPACK), LABETALOL HCL (REMEDYREPACK), LABETALOL HYDROCHLORIDE (Akorn), LABETALOL HYDROCHLORIDE (American Health Packaging), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Bryant Ranch Prepack), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Cardinal Health), LABETALOL HYDROCHLORIDE (Dispensing Solutions), LABETALOL HYDROCHLORIDE (Gland Pharma Limited), LABETALOL HYDROCHLORIDE (Golden State Medical Supply), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (Hospira), LABETALOL HYDROCHLORIDE (IVAX Pharmaceuticals), LABETALOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), LABETALOL HYDROCHLORIDE (Major Pharmaceuticals), LABETALOL HYDROCHLORIDE (McKesson Contract Packaging), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HYDROCHLORIDE (NCS HealthCare of KY), LABETALOL HCL (Par Pharmaceutical Companies), LABETALOL HYDROCHLORIDE (Physicians Total Care), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (REMEDYREPACK), LABETALOL HYDROCHLORIDE (Rebel Distributors Corp), LABETALOL HYDROCHLORIDE (Rebel Distributors Corp), LABETALOL HYDROCHLORIDE (STAT RX USA LLC), LABETALOL (Sagent Pharmaceuticals), LABETALOL HYDROCHLORIDE (St Marys Medical Park Pharmacy), LABETALOL HYDROCHLORIDE (Unit Dose Services), LABETALOL HYDROCHLORIDE (Unit Dose Services), LABETALOL HYDROCHLORIDE (Watson Laboratories)
  Other
Formula
C19H24N2O3. HCl
Exact mass
364.1554
Mol weight
364.8664
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [alpha-receptor];
Anti-adrenergic [beta-receptor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG01 Labetalol
      D00600  Labetalol hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Labetalol
    D00600  Labetalol hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00600  Labetalol hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP16/USP)
    beta1-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP16/USP)
    beta2-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP16/USP)
    beta3-adrenergic receptor
     Labetalol
      D00600  Labetalol hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00600  Labetalol hydrochloride
  D00600  Labetalol hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 
32780-64-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    13.1600  -15.8200
            2   C8y C    13.1600  -14.4200
            3   C8x C    14.3500  -13.7200
            4   C8x C    15.6100  -14.4200
            5   C8y C    15.6100  -15.8200
            6   C8x C    14.3500  -16.5200
            7   C1c C    16.8000  -16.5200
            8   C1b C    18.0600  -15.8200
            9   N1b N    19.2500  -16.5200
            10  C1c C    20.4400  -15.8200
            11  C1b C    21.7000  -16.5200
            12  C1b C    22.8900  -15.8200
            13  C8y C    24.0800  -16.5200
            14  C5a C    11.9700  -16.5200
            15  N1a N    10.7800  -15.8200
            16  O5a O    11.9700  -17.9200
            17  O1a O    11.9700  -13.7200
            18  O1a O    16.8000  -17.9200
            19  C1a C    20.4400  -14.4200
            20  C8x C    25.3400  -15.8200
            21  C8x C    26.5300  -16.5200
            22  C8x C    26.5300  -17.9200
            23  C8x C    25.3400  -18.6200
            24  C8x C    24.0800  -17.9200
            25  X   Cl   25.6900  -13.6500
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    1  14 1
            15   14  15 1
            16   14  16 2
            17    2  17 1
            18    7  18 1
            19   10  19 1
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1

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