KEGG   DRUG: Guanfacine hydrochlorideHelp
Entry
D00606                      Drug                                   

Name
Guanfacine hydrochloride (JAN/USP);
Tenex (TN)
Product
  Generic
GUANFACINE (Actavis Pharma), GUANFACINE (Actavis Pharma), GUANFACINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), GUANFACINE HYDROCHLORIDE (Atlantic Biologicals Corps), GUANFACINE (AvKARE), GUANFACINE HYDROCHLORIDE (AvPAK), GUANFACINE (Avera McKennan Hospital), GUANFACINE (Avera McKennan Hospital), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Cardinal Health), GUANFACINE (Carilion Materials Management), GUANFACINE (Epic Pharma), GUANFACINE (Golden State Medical Supply), GUANFACINE HYDROCHLORIDE (Mylan Pharmaceuticals), GUANFACINE (Par Pharmaceutical), GUANFACINE (Physicians Total Care), GUANFACINE (Proficient Rx LP), GUANFACINE (PuraCap Laboratories), GUANFACINE (REMEDYREPACK), GUANFACINE (Sandoz), GUANFACINE (TWi Pharmaceuticals), GUANFACINE (Teva Pharmaceuticals USA), GUANFACINE HYDROCHLORIDE (American Health Packaging), GUANFACINE HYDROCHLORIDE (AvKARE), GUANFACINE (Cardinal Health), GUANFACINE (Golden State Medical Supply), GUANFACINE HYDROCHLORIDE (Major Pharmaceuticals), GUANFACINE (Mylan Pharmaceuticals), GUANFACINE (Physicians Total Care), GUANFACINE (REMEDYREPACK), GUANFACINE HYDROCHLORIDE (TYA Pharmaceuticals)
Formula
C9H9Cl2N3O. HCl
Exact mass
280.9889
Mol weight
282.5542
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, alpha2-Adrenergic receptor agonist
  Disease
Attention Deficit Hyperactivity Disorder (ADHD) [DS:H01895]
Comment
Guanidine derivative
Target
ADRA2A [HSA:150] [KO:K04138]
  Pathway
Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC02 Guanfacine
      D00606  Guanfacine hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Guanfacine
    D00606  Guanfacine hydrochloride (JAN/USP)
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non- amphetamines
   Guanfacine
    D00606  Guanfacine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00606  Guanfacine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha2-adrenergic receptor
     Guanfacine
      D00606  Guanfacine hydrochloride (JAN/USP)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00606
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00606
BRITE hierarchy
Other DBs
CAS: 
29110-48-3
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    24.2186  -16.1239
            2   C1b C    23.0015  -15.4193
            3   C8y C    24.2070  -17.5156
            4   C8y C    25.4239  -15.4134
            5   C5a C    21.7961  -16.1239
            6   C8x C    25.4239  -18.2144
            7   X   Cl   22.9956  -18.2087
            8   C8x C    26.6353  -16.1122
            9   X   Cl   25.4182  -14.0101
            10  N1b N    20.5848  -15.4193
            11  O5a O    21.7961  -17.5215
            12  C8x C    26.6353  -17.5156
            13  C2c C    19.3677  -16.1239
            14  N1a N    18.1565  -15.4193
            15  N2a N    19.3677  -17.5215
            16  X   Cl   29.0752  -16.4966
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 2
            15    8  12 1

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