KEGG   DRUG: D00607Help
Entry
D00607                      Drug                                   

Name
Guanadrel sulfate (USP);
Hylorel (TN)
Formula
(C10H19N3O2)2. H2SO4
Exact mass
524.2628
Mol weight
524.632
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Guanadrel
      D00607  Guanadrel sulfate (USP)
    alpha2-adrenergic receptor
     Guanadrel
      D00607  Guanadrel sulfate (USP)
BRITE hierarchy
Other DBs
CAS: 
22195-34-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C1y C    31.3600  -15.5400
            2   C1b C    30.1000  -16.2400
            3   N1b N    28.9100  -15.4000
            4   C2c C    27.5100  -16.1700
            5   N1a N    26.2500  -15.3300
            6   N2a N    27.5100  -17.7100
            7   C1x C    31.3600  -14.1400
            8   O2x O    32.6900  -15.9600
            9   C1z C    33.5300  -14.8400
            10  O2x O    32.6900  -13.7200
            11  C1x C    34.2300  -16.0300
            12  C1x C    35.6300  -16.0300
            13  C1x C    36.3300  -14.8400
            14  C1x C    35.6300  -13.5800
            15  C1x C    34.2300  -13.5800
            16  S4a S    40.0820  -15.5800
            17  O1d O    40.0820  -14.1800
            18  O1d O    40.0820  -16.9800
            19  O1d O    38.6819  -15.5800
            20  O1d O    41.4819  -15.5800
            21  C1y C    31.3600  -15.5400
            22  C1b C    30.1000  -16.2400
            23  N1b N    28.9100  -15.4000
            24  C2c C    27.5100  -16.1700
            25  N1a N    26.2500  -15.3300
            26  N2a N    27.5100  -17.7100
            27  C1x C    31.3600  -14.1400
            28  O2x O    32.6900  -13.7200
            29  C1z C    33.5300  -14.8400
            30  O2x O    32.6900  -15.9600
            31  C1x C    34.2300  -16.0300
            32  C1x C    35.6300  -16.0300
            33  C1x C    36.3300  -14.8400
            34  C1x C    35.6300  -13.5800
            35  C1x C    34.2300  -13.5800
BOND        36
            1    16  17 2
            2    16  18 2
            3    16  19 1
            4    16  20 1
            5     1   2 1
            6     2   3 1
            7     3   4 1
            8     4   5 1
            9     4   6 2
            10    1   7 1
            11    1   8 1
            12    8   9 1
            13    9  10 1
            14    7  10 1
            15    9  11 1
            16   11  12 1
            17   12  13 1
            18   13  14 1
            19   14  15 1
            20    9  15 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   24  26 2
            26   21  27 1
            27   21  30 1
            28   30  29 1
            29   29  28 1
            30   27  28 1
            31   29  31 1
            32   31  32 1
            33   32  33 1
            34   33  34 1
            35   34  35 1
            36   29  35 1
BRACKET     1    24.5700  -18.4800   24.5700  -13.0900
            1    36.7500  -13.0900   36.7500  -18.4800
            1  2
 ORIGINAL  1    1   2   3   4   5   6   7  10   9   8  11  12  13  14  15
 REPEAT    1   21  22  23  24  25  26  27  28  29  30  31  32  33  34  35

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