KEGG   DRUG: D00608Help
Entry
D00608                      Drug                                   

Name
Doxazosin mesilate (JP16);
Doxazosin mesylate (USAN);
Cardura (TN)
Product
  Generic
DOXAZOSIN (Apotex Corp.), DOXAZOSIN (Cardinal Health), DOXAZOSIN (Legacy Pharmaceutical Packaging), DOXAZOSIN (Major Pharmaceuticals), DOXAZOSIN (Preferred Pharmaceuticals), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (Stat Rx USA), DOXAZOSIN (Aidarex Pharmaceuticals LLC), DOXAZOSIN (Bryant Ranch Prepack), DOXAZOSIN (Bryant Ranch Prepack), DOXAZOSIN (Bryant Ranch Prepack), DOXAZOSIN (Cardinal Health), DOXAZOSIN MESYLATE (DAVA Pharmaceuticals), DOXAZOSIN MESYLATE (Dispensing Solutions), DOXAZOSIN MESYLATE (Golden State Medical Supply), DOXAZOSIN (Lake Erie Medical DBA Quality Care Products LLC), DOXAZOSIN (Lake Erie Medical DBA Quality Care Products LLC), DOXAZOSIN MESYLATE (Major Pharmaceuticals), DOXAZOSIN (Mylan Institutional), DOXAZOSIN (Mylan Pharmaceuticals), DOXAZOSIN (NCS HealthCare of KY), DOXAZOSIN (PD-Rx Pharmaceuticals), DOXAZOSIN (PD-Rx Pharmaceuticals), DOXAZOSIN (Physicians Total Care), DOXAZOSIN (Preferred Pharmaceuticals), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN (Rebel Distributors Corp), DOXAZOSIN (St Marys Medical Park Pharmacy), DOXAZOSIN (State of Florida DOH Central Pharmacy), DOXAZOSIN MESYLATE (State of Florida DOH Central Pharmacy), DOXAZOSIN (Teva Pharmaceuticals USA), DOXAZOSIN (Teva Pharmaceuticals USA), DOXAZOSIN (Unit Dose Services), DOXAZOSIN (Unit Dose Services), DOXAZOSIN (Unit Dose Services)
Formula
C23H25N5O5. CH4SO3
Exact mass
547.1737
Mol weight
547.5808
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00608  Doxazosin mesilate (JP16); Doxazosin mesylate (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA04 Doxazosin
      D00608  Doxazosin mesilate (JP16); Doxazosin mesylate (USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Doxazosin
    D00608  Doxazosin mesilate (JP16); Doxazosin mesylate (USAN)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Doxazosin
    D00608  Doxazosin mesilate (JP16); Doxazosin mesylate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Doxazosin [ATC:C02CA04]
      D00608  Doxazosin mesylate (USAN)
BRITE hierarchy
Other DBs
CAS: 
77883-43-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        38
            1   C8y C    31.6040  -15.7396
            2   C8y C    31.5972  -17.1405
            3   N5x N    30.3332  -15.0390
            4   C8x C    32.7548  -15.0458
            5   C8x C    32.7415  -17.8476
            6   C8y C    30.3131  -17.8410
            7   C8y C    29.1124  -15.7328
            8   C8y C    33.9624  -15.7529
            9   C8y C    33.9556  -17.1539
            10  N5x N    29.1057  -17.1339
            11  N1a N    30.3131  -19.2419
            12  N1y N    27.8983  -15.0325
            13  O2a O    35.1764  -15.0592
            14  O2a O    35.1698  -17.8609
            15  C1x C    26.6841  -15.7195
            16  C1x C    27.9049  -13.6249
            17  C1a C    36.3905  -15.7663
            18  C1a C    36.3839  -17.1672
            19  C1x C    25.4765  -15.0191
            20  C1x C    26.6974  -12.9243
            21  N1y N    25.4899  -13.6249
            22  C5a C    24.2756  -12.9177
            23  C1y C    23.0549  -13.6115
            24  O5a O    24.2824  -11.5167
            25  O2x O    21.8407  -12.9044
            26  C1x C    23.0484  -15.0123
            27  C8y C    20.6266  -13.6047
            28  O2x O    21.8341  -15.7061
            29  C8y C    20.6200  -15.0058
            30  C8x C    19.4191  -12.8976
            31  C8x C    19.4191  -15.6995
            32  C8x C    18.1984  -13.6047
            33  C8x C    18.1984  -15.0058
            34  S4a S    22.5632  -18.8794
            35  C1a C    21.1692  -18.8727
            36  O1d O    23.9576  -18.8794
            37  O1d O    22.5567  -17.4851
            38  O1d O    22.5567  -20.2737
BOND        41
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   12  15 1
            15   12  16 1
            16   13  17 1
            17   14  18 1
            18   15  19 1
            19   16  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28   27  29 1
            29   27  30 2
            30   29  31 2
            31   30  32 1
            32   31  33 1
            33    7  10 2
            34    8   9 1
            35   20  21 1
            36   28  29 1
            37   32  33 2
            38   34  35 1
            39   34  36 1
            40   34  37 2
            41   34  38 2

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