KEGG   DRUG: Doxazosin mesylateHelp
Entry
D00608                      Drug                                   

Name
Doxazosin mesylate (USAN);
Doxazosin mesilate (JP17);
Cardura (TN)
Product
  Generic
DOXAZOSIN (Accord Healthcare), DOXAZOSIN (American Health Packaging), DOXAZOSIN (Apotex Corp.), DOXAZOSIN (AvKARE), DOXAZOSIN (Cadila Healthcare Limited), DOXAZOSIN (Cardinal Health), DOXAZOSIN (Legacy Pharmaceutical Packaging), DOXAZOSIN (Legacy Pharmaceutical Packaging), DOXAZOSIN (Major Pharmaceuticals), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (PD-Rx Pharmaceuticals), DOXAZOSIN (Preferred Pharmaceuticals), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (REMEDYREPACK), DOXAZOSIN (St Marys Medical Park Pharmacy), DOXAZOSIN (Stat Rx USA), DOXAZOSIN (Unit Dose Services), DOXAZOSIN (Zydus Pharmaceuticals (USA)), DOXAZOSIN (Aidarex Pharmaceuticals LLC), DOXAZOSIN (Aphena Pharma Solutions - Tennessee), DOXAZOSIN (Aphena Pharma Solutions - Tennessee), DOXAZOSIN MESYLATE (AvPAK), DOXAZOSIN MESYLATE (Blenheim Pharmacal), DOXAZOSIN (Bryant Ranch Prepack), DOXAZOSIN (Bryant Ranch Prepack), DOXAZOSIN (Bryant Ranch Prepack), DOXAZOSIN (Cardinal Health), DOXAZOSIN MESYLATE (DAVA Pharmaceuticals), DOXAZOSIN MESYLATE (Dispensing Solutions), DOXAZOSIN MESYLATE (Golden State Medical Supply), DOXAZOSIN (Lake Erie Medical DBA Quality Care Products LLC), DOXAZOSIN (Lake Erie Medical DBA Quality Care Products LLC), DOXAZOSIN (Lake Erie Medical DBA Quality Care Products LLC), DOXAZOSIN MESYLATE (Major Pharmaceuticals), DOXAZOSIN (Mylan Institutional), DOXAZOSIN (Mylan Pharmaceuticals), DOXAZOSIN (NCS HealthCare of KY), DOXAZOSIN (NuCare Pharmaceuticals), DOXAZOSIN (PD-Rx Pharmaceuticals), DOXAZOSIN (PD-Rx Pharmaceuticals), DOXAZOSIN (Physicians Total Care), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN MESYLATE (REMEDYREPACK), DOXAZOSIN (Rebel Distributors Corp), DOXAZOSIN (St Marys Medical Park Pharmacy), DOXAZOSIN (State of Florida DOH Central Pharmacy), DOXAZOSIN MESYLATE (State of Florida DOH Central Pharmacy), DOXAZOSIN MESYLATE (State of Florida DOH Central Pharmacy), DOXAZOSIN (Teva Pharmaceuticals USA), DOXAZOSIN (Unit Dose Services)
Formula
C23H25N5O5. CH4SO3
Exact mass
547.1737
Mol weight
547.5808
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01739  Peripherally-acting antiadrenergic
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, alpha1-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Prazosin derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA04 Doxazosin
      D00608  Doxazosin mesylate (USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Doxazosin
    D00608  Doxazosin mesylate (USAN)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Doxazosin
    D00608  Doxazosin mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00608  Doxazosin mesylate (USAN); Doxazosin mesilate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Doxazosin
      D00608  Doxazosin mesylate (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00608  Doxazosin mesilate
  D00608  Doxazosin mesilate tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00608
BRITE hierarchy
Other DBs
CAS: 
77883-43-3
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        38
            1   C8y C    31.6040  -15.7396
            2   C8y C    31.5972  -17.1405
            3   N5x N    30.3332  -15.0390
            4   C8x C    32.7548  -15.0458
            5   C8x C    32.7415  -17.8476
            6   C8y C    30.3131  -17.8410
            7   C8y C    29.1124  -15.7328
            8   C8y C    33.9624  -15.7529
            9   C8y C    33.9556  -17.1539
            10  N5x N    29.1057  -17.1339
            11  N1a N    30.3131  -19.2419
            12  N1y N    27.8983  -15.0325
            13  O2a O    35.1764  -15.0592
            14  O2a O    35.1698  -17.8609
            15  C1x C    26.6841  -15.7195
            16  C1x C    27.9049  -13.6249
            17  C1a C    36.3905  -15.7663
            18  C1a C    36.3839  -17.1672
            19  C1x C    25.4765  -15.0191
            20  C1x C    26.6974  -12.9243
            21  N1y N    25.4899  -13.6249
            22  C5a C    24.2756  -12.9177
            23  C1y C    23.0549  -13.6115
            24  O5a O    24.2824  -11.5167
            25  O2x O    21.8407  -12.9044
            26  C1x C    23.0484  -15.0123
            27  C8y C    20.6266  -13.6047
            28  O2x O    21.8341  -15.7061
            29  C8y C    20.6200  -15.0058
            30  C8x C    19.4191  -12.8976
            31  C8x C    19.4191  -15.6995
            32  C8x C    18.1984  -13.6047
            33  C8x C    18.1984  -15.0058
            34  S4a S    22.5632  -18.8794
            35  C1a C    21.1692  -18.8727
            36  O1d O    23.9576  -18.8794
            37  O1d O    22.5567  -17.4851
            38  O1d O    22.5567  -20.2737
BOND        41
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   12  15 1
            15   12  16 1
            16   13  17 1
            17   14  18 1
            18   15  19 1
            19   16  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28   27  29 1
            29   27  30 2
            30   29  31 2
            31   30  32 1
            32   31  33 1
            33    7  10 2
            34    8   9 1
            35   20  21 1
            36   28  29 1
            37   32  33 2
            38   34  35 1
            39   34  36 1
            40   34  37 2
            41   34  38 2

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