KEGG   DRUG: D00609Help
Entry
D00609                      Drug                                   

Name
Prazosin hydrochloride (JP16/USP);
Minipress (TN)
Product
  Generic
PRAZOSIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Carilion Materials Management), PRAZOSIN HYDROCHLORIDE (Mylan Institutional), PRAZOSIN HYDROCHLORIDE (Mylan Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Physicians Total Care), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (TYA Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C19H21N5O4. HCl
Exact mass
419.136
Mol weight
419.8621
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Transporter inhibition: SLC22A3 [HSA:6581]
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA01 Prazosin
      D00609  Prazosin hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Prazosin
    D00609  Prazosin hydrochloride (JP16/USP)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Prazosin
    D00609  Prazosin hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00609  Prazosin hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Prazosin
      D00609  Prazosin hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00609  Prazosin hydrochloride
BRITE hierarchy
Other DBs
CAS: 
19237-84-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8y C    33.1529  -18.8898
            2   C8y C    33.1529  -17.4829
            3   C8x C    34.3789  -19.5962
            4   C8y C    31.9444  -19.5962
            5   N5x N    31.9444  -16.7997
            6   C8x C    34.3789  -16.7997
            7   C8y C    35.5815  -18.8898
            8   N5x N    30.7358  -18.8898
            9   N1a N    31.9444  -20.9974
            10  C8y C    30.7358  -17.4829
            11  C8y C    35.5815  -17.4829
            12  O2a O    36.8134  -19.5962
            13  N1y N    29.5273  -16.7997
            14  O2a O    36.8134  -16.7997
            15  C1a C    38.0162  -18.8839
            16  C1x C    29.5273  -15.4044
            17  C1x C    28.3071  -17.4829
            18  C1a C    38.0162  -17.4944
            19  C1x C    28.3071  -14.6979
            20  C1x C    27.0985  -16.7997
            21  N1y N    27.0985  -15.4044
            22  C5a C    25.8726  -14.6979
            23  C8y C    24.6581  -15.4044
            24  O5a O    25.8726  -13.2909
            25  C8x C    24.2844  -16.7355
            26  O2x O    23.5022  -14.6220
            27  C8x C    22.8541  -16.7063
            28  C8x C    22.3929  -15.4803
            29  X   Cl   41.7809  -18.0958
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 2
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28    7  11 1
            29    8  10 1
            30   20  21 1
            31   27  28 2

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