KEGG   DRUG: D00609Help
Entry
D00609                      Drug                                   

Name
Prazosin hydrochloride (JP16/USP);
Minipress (TN)
Product
  Generic
Formula
C19H21N5O4. HCl
Exact mass
419.136
Mol weight
419.8621
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Transporter inhibition: SLC22A3 [HSA:6581]
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA01 Prazosin
      D00609  Prazosin hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Prazosin
    D00609  Prazosin hydrochloride (JP16/USP)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Prazosin
    D00609  Prazosin hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00609  Prazosin hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Prazosin
      D00609  Prazosin hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00609  Prazosin hydrochloride
BRITE hierarchy
Other DBs
CAS: 
19237-84-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8y C    33.1529  -18.8898
            2   C8y C    33.1529  -17.4829
            3   C8x C    34.3789  -19.5962
            4   C8y C    31.9444  -19.5962
            5   N5x N    31.9444  -16.7997
            6   C8x C    34.3789  -16.7997
            7   C8y C    35.5815  -18.8898
            8   N5x N    30.7358  -18.8898
            9   N1a N    31.9444  -20.9974
            10  C8y C    30.7358  -17.4829
            11  C8y C    35.5815  -17.4829
            12  O2a O    36.8134  -19.5962
            13  N1y N    29.5273  -16.7997
            14  O2a O    36.8134  -16.7997
            15  C1a C    38.0162  -18.8839
            16  C1x C    29.5273  -15.4044
            17  C1x C    28.3071  -17.4829
            18  C1a C    38.0162  -17.4944
            19  C1x C    28.3071  -14.6979
            20  C1x C    27.0985  -16.7997
            21  N1y N    27.0985  -15.4044
            22  C5a C    25.8726  -14.6979
            23  C8y C    24.6581  -15.4044
            24  O5a O    25.8726  -13.2909
            25  C8x C    24.2844  -16.7355
            26  O2x O    23.5022  -14.6220
            27  C8x C    22.8541  -16.7063
            28  C8x C    22.3929  -15.4803
            29  X   Cl   41.7809  -18.0958
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 2
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28    7  11 1
            29    8  10 1
            30   20  21 1
            31   27  28 2

» Japanese version   » Back

DBGET integrated database retrieval system