KEGG   DRUG: D00610Help
Entry
D00610                      Drug                                   

Name
Terazosin hydrochloride hydrate (JAN);
Terazosin hydrochloride (USAN);
Hytrin (TN)
Product
  Generic
TERAZOSIN (Aidarex Pharmaceuticals LLC), TERAZOSIN (Apotex Corp.), TERAZOSIN HYDROCHLORIDE (NCS HealthCare of KY), TERAZOSIN (Preferred Pharmaceuticals), TERAZOSIN (REMEDYREPACK), TERAZOSIN (REMEDYREPACK), TERAZOSIN (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TERAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TERAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TERAZOSIN HYDROCHLORIDE (Cardinal Health), TERAZOSIN (Jubilant Cadista Pharmaceuticals), TERAZOSIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TERAZOSIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TERAZOSIN HYDROCHLORIDE (Major Pharmaceuticals), TERAZOSIN HYDROCHLORIDE (Physicians Total Care), TERAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (REMEDYREPACK), TERAZOSIN HYDROCHLORIDE (Rebel Distributors Corp), TERAZOSIN HYDROCHLORIDE (STAT Rx USA LLC), TERAZOSIN HYDROCHLORIDE (Sandoz), TERAZOSIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), TERAZOSIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), TERAZOSIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), TERAZOSIN HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C19H25N5O4. 2H2O. HCl
Exact mass
459.1885
Mol weight
459.9244
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Target
alpha1-adrenergic receptor antagonist [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00610  Terazosin hydrochloride hydrate (JAN); Terazosin hydrochloride (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA03 Terazosin
      D00610  Terazosin hydrochloride hydrate (JAN); Terazosin hydrochloride (USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Terazosin
    D00610  Terazosin hydrochloride hydrate (JAN); Terazosin hydrochloride (USAN)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Terazosin
    D00610  Terazosin hydrochloride hydrate (JAN); Terazosin hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Terazosin [ATC:G04CA03]
      D00610  Terazosin hydrochloride hydrate (JAN); Terazosin hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
70024-40-7
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        31
            1   C8y C    31.5616  -18.9123
            2   C8y C    31.5616  -17.5048
            3   C8x C    32.7916  -19.6220
            4   C8y C    30.3553  -19.6220
            5   N5x N    30.3553  -16.8247
            6   C8x C    32.7916  -16.8247
            7   C8y C    33.9921  -18.9123
            8   N5x N    29.1488  -18.9123
            9   N1a N    30.3553  -21.0235
            10  C8y C    29.1488  -17.5048
            11  C8y C    33.9921  -17.5048
            12  O2a O    35.2223  -19.6220
            13  N1y N    27.9365  -16.8247
            14  O2a O    35.2223  -16.8247
            15  C1a C    36.4286  -18.9063
            16  C1x C    27.9365  -15.4290
            17  C1x C    26.7184  -17.5048
            18  C1a C    36.4286  -17.5167
            19  C1x C    26.7184  -14.7195
            20  C1x C    25.5119  -16.8247
            21  N1y N    25.5119  -15.4290
            22  C5a C    24.2600  -14.7132
            23  C1y C    23.0787  -15.4020
            24  O5a O    24.3238  -13.3005
            25  C1x C    23.0787  -16.8020
            26  O2x O    21.7472  -14.9694
            27  C1x C    20.9243  -16.1020
            28  C1x C    21.7472  -17.2346
            29  O0  O    41.8575  -18.0785
            30  X   Cl   41.1600  -15.7500
            31  O0  O    41.8575  -18.0785
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21    7  11 1
            22    8  10 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 2
            27   23  25 1
            28   23  26 1
            29   26  27 1
            30   27  28 1
            31   25  28 1
BRACKET     1    39.5500  -19.0400   39.5500  -17.3600
            1    42.6300  -17.3600   42.6300  -19.0400
            1  2
 ORIGINAL  1   29
 REPEAT    1   31

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